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冠状病毒抑制剂|New coronavirus inhibitor
SARS-CoV（SARS冠状病毒）是引起严重急性呼吸道综合症（SARS）的病毒。 冠状病毒编码的木瓜蛋白酶样蛋白酶（PLpro）通常是具有蛋白酶活性的多功能酶，具有加工病毒复制酶多蛋白和去泛素化（DUB）/ deISGylating活性的作用，假定该酶可以修饰对感染的先天免疫应答。冠状病毒抑制剂主要用于新型新型冠状病毒的先导化合物，进行抗新型冠状病毒（2019-nCoV）潜在药物的筛选研究和新药研发使用，不可直接应用于人体使用。The study of the structure of virus is an important implication for the exploring and development of effective antivirals. At present, S protein, TMPRSS2, ACE2, RdRp, and Mpro are primary targets. For example, Lopinavir as a protease inhibitor combined with Ritonavir performs against antiretroviral activity. Remdesivir, as a nucleotide analogue, shows an effective activity against SARS-CoV-2 through inhibiting RdRp.
