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货品编码 规格 纯度 价格 (¥) 现价(¥) 特价(¥) 库存描述 数量 总计 (¥)
HCY000001-10mg 97% ¥ 850.00 ¥ 850.00
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中文别名 利托那韦-D6;CS-477;A84538;ABT538;ABBOTT84538;NSC693184;NORVIR;RTV;N-[(2S,3S,5R)-3-羟基-5-[[(2S)-3-甲基-2-[[甲基-[(2-异丙基-1,3-噻唑-4-基)甲基]氨基甲酰]氨基]丁酰]氨基]-1,6-二苯基-己-2-基]氨基甲酸5-噻唑基甲基酯;利托那韦;利托那韦相关物质混合物;N-[(2S,3S,5R)-3-羟基-5-[[(2S)-3-甲基-2-[[甲基-[(2-异丙基-1,3-噻唑-4-基)甲基]氨基甲酰]氨基]丁酰]氨基]-1,6-二苯基-己-2-基]氨基甲酸;利里利杂质
英文别名 Ritonavire;1,3-thiazol-5-ylmethyln-[(2s,3s,5r)-3-hydroxy-5-[[(2s)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenyl-hexan-2-yl]carbamate;1,3-THIAZOL-5-YLMETHANOL;CHEMBRDG-BB4050354;THIAZOL-5-YL-METHANOL;RITONAVIR;RARECHEMALBD1261;1,3-Thiazol-5-ylmethylN-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
CAS号 155213-67-5
SMILES CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
Inchi
InchiKey
分子式 Molecular Weight C37H48N6O5S2
分子量 Formula 720.9g/mol
闪点 FP 526.6±34.3 °C
熔点 Melting point 120-122°C
沸点 Boiling point 947.0±65.0 °C
物理属性 Physical property powder
密度 Density
蒸汽压 Vapor Pressure 0.0±0.3 mmHg at 25°C
溶解度Solubility DMSO: soluble10mg/mL
化学性质Characters white to beige,powder
储藏条件 Storage conditions -20°C
产品说明 洛匹那韦和利托那韦构成的合剂就是克力芝,但由于抗病毒效果好、耐药屏障高,目前仍作为主要的抗HIV治疗药物应用于临床,克力芝在我国也是作为免费抗病毒药物提供给HIV感染者的。
IntroductionRitonavir is an L-valine derivative that is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS.
Application1最新研究表明瑞托那韦可作为新冠状病毒的先导化合物作为新型冠状病毒新药研发在科研中使用。
Application2冠状病毒的复制也需要病毒蛋白酶的作用。
Application3
警示图
危险性 Warning
危险性警示 暂无数据
安全声明 H302+H312+H332
安全防护
备注
Peter T. A. Galek, Frank H. Allen, László Fábián and Neil Feeder. Knowledge-based H-bond prediction to aid experimental polymorph screening, CrystEngComm, 2009, 11, 2634.
Ravi N. Tiwari and Chandrakant G. Bonde. LC, LC-MS/TOF and MSn studies for the separation, identification and characterization of degradation products of ritonavir, Anal. Methods, 2011, 3, 1674.
Marylynn V. Yates and Wilfred Chen. A quantum-dot based protein module for in vivo monitoring of protease activity through fluorescence resonance energy transfer, Chem. Commun., 2011, 47, 5259.
Pauli-Magnus C. Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers.
Prediction of drug-drug interactions between various antidepressants and efavirenz or boosted protease inhibitors using a physiologically based pharmacokinetic modelling approach
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