逆转录酶|Reverse Transcriptase
逆转录酶(RTs)是用于从RNA模板生成互补DNA(cDNA)的酶,该过程称为逆转录。 逆转录酶(RTs)使用RNA模板和与RNA 3'末端互补的短引物指导第一链cDNA的合成。
核苷逆转录酶抑制剂(NRTIs)阻断逆转录酶(一种HIV酶)。 非核苷逆转录酶抑制剂(NNRTIs)结合并阻断HIV逆转录酶。 HIV使用逆转录酶将其RNA转化为DNA(逆转录)。 阻断逆转录酶和逆转录阻止HIV复制。
Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.
Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.