108212-76-6|N-乙酰-加利车霉素|N-Acetyl-Calicheamicin|MFCD29924715-范德生物科技公司

N-乙酰-加利车霉素

NMR下载 COA and HPLC MSDS下载
names：
N-Acetyl-Calicheamicin
CAS号：
108212-76-6
MDL Number： MFCD29924715
MF(分子式)： C57H76IN3O22S4 MW(分子量)： 1410.39
EINECS: Reaxys Number:
Pubchem ID:122705998 Brand:BIOFOUNT

N-乙酰-加利车霉素(108212-76-6,N-Acetyl-Calicheamicin)是一类高活性抗肿瘤的抗生素。N-乙酰-加利车霉素是一种有效的烯二炔抗肿瘤抗生素。目标：抗菌N-乙酰-卡奇霉素是卡利奇霉素的一种衍生物。Calicheamicin是一种天然存在的疏水性烯二炔抗生素，从放线菌微单孢菌echinospora calichensis中分离出来。加里车霉素不仅可以通过切割游离DNA来干扰生物过程，而且可以通过竞争或调节DNA结构来取代DNA结合蛋白，从而干扰生物过程。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000161-5mg	5mg	>98.0%	¥ 65750.00	¥ 65750.00		2-3天	- +	¥ 0.00
YZM000161-1mg	1mg	>98.0%	¥ 18550.00	¥ 18550.00		2-3天	- +	¥ 0.00

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中文别名	N-乙酰-加利车霉素(108212-76-6); N-乙酰-加利车霉素γ1; N-乙酰-加利车霉素γ; N-乙酰-加利车霉素; N-乙酰-γ-卡奇霉素;
英文别名	N-Acetyl-Calicheamicin(108212-76-6);CS-5417;HY-19791; N-Acetyl-Calicheamicin γ1; N-Acetyl-Calicheamicin γ; N-Acetyl-Calicheamicin; N-Acetyl-γ-calicheamicin；
CAS号	108212-76-6
SMILES	O[C@](CC1=O)(C#C/C=C\C#C2)/C(C([C@H]2O[C@@](O[C@H](C)[C@@H](NO[C@H](O[C@H](C)[C@H]3SC(C(C(C)=C(I)C(O[C@H](O[C@@H](C)[C@H](O)[C@H]4OC)[C@@H]4O)=C5OC)=C5OC)=O)C[C@@H]3O)[C@@H]6O)([H])[C@@H]6O[C@@](OC[C@@H]7N(CC)C(C)=O)([H])C[C@@H]7OC)=C1NC(OC)=O)=C/CSSSC
Inchi	InChI=1S/C57H76IN3O22S4/c1-13-61(30(6)62)32-25-76-37(23-36(32)71-7)81-50-45(66)42(27(3)78-55(50)80-35-18-16-14-15-17-20-57(70)24-34(64)43(59-56(69)75-11)40(35)31(57)19-21-85-87-84-12)60-83-38-22-33(63)52(29(5)77-38)86-53(68)39-26(2)41(58)48(51(74-10)47(39)72-8)82-54-46(67)49(73-9)44(65)28(4)79-54/h14-15,19,27-29,32-33,35-38,42,44-46,49-50,52,54-55,60,63,65-67,70H,13,21-25H2,1-12H3,(H,59,69)/b15-14-,31-19+/t27-,28+,29-,32+,33+,35+,36+,37+,38+,42-,44+,45+,46-,49-,50-,52-,54+,55+,57+/m1/s1
InchiKey	WPDOZYZAJKUVRZ-IOCYQWGVSA-N
分子式 Formula	C57H76IN3O22S4
分子量 Molecular Weight	1410.39
闪点 FP
熔点 Melting point	No data available
沸点 Boiling point
Polarizability极化度	131.7±0.5 10-24cm3
密度 Density	1.6±0.1 g/cm3
蒸汽压 Vapor Pressure
溶解度Solubility
性状	固体粉末,Power
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

N-乙酰-加利车霉素(108212-76-6,N-Acetyl-Calicheamicin)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	N-乙酰-加利车霉素(108212-76-6,N-Acetyl-Calicheamicin)是一种有效的烯二炔抗肿瘤抗生素。
Introduction	N-乙酰-加利车霉素(108212-76-6,N-Acetyl-Calicheamicin) is a potent enediyne antitumor antibiotic.
Application1	N-乙酰基加利车霉素是一种有效的烯二炔抗肿瘤抗生素，可用于抗体-药物结合（ADC）。
Application2
Application3

N-乙酰-加利车霉素(108212-76-6,N-Acetyl-Calicheamicin)药理学：

1、N-乙酰-加利车霉素是一种有效的烯二炔抗肿瘤抗生素。目标：抗菌N-乙酰-卡奇霉素是卡利奇霉素的一种衍生物。Calicheamicin是一种天然存在的疏水性烯二炔抗生素，从放线菌微单孢菌echinospora calichensis中分离出来。加里车霉素不仅可以通过切割游离DNA来干扰生物过程，而且可以通过竞争或调节DNA结构来取代DNA结合蛋白，从而干扰生物过程。

2、N-乙酰-卡利奇霉素是卡利奇霉素的衍生物，是烯二炔抗肿瘤抗生素的一种，可能是潜在的细胞毒性DNA结合剂。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

N-乙酰-加利车霉素(108212-76-6,N-Acetyl-Calicheamicin)危害标识：

象形图


信号	Danger
GHS危险说明	Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
	H300 (50%): Fatal if swallowed [Danger Acute toxicity, oral]
	H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
	H310 (50%): Fatal in contact with skin [Danger Acute toxicity, dermal]
	H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
	H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
	H330 (50%): Fatal if inhaled [Danger Acute toxicity, inhalation]
	H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
	H341 (50%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
	H351 (50%): Suspected of causing cancer [Warning Carcinogenicity]
	H361 (50%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
	H372 (50%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P201, P202, P260, P261, P262, P264, P270, P271, P280, P281, P284, P301+P310, P301+P312, P302+P350, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P314, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501
防范说明代码	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Stasi R, et al. Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia. Cancer Treat Rev. 2008 Feb;34(1):49-60.

Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia PMID 17942233; Cancer treatment reviews 2008 Feb; 34(1):49-60 (Review Article) Name matches: 1,2-dimethyl-hydrazine dichloride n-acetyl

N-乙酰-加利车霉素(108212-76-6,N-Acetyl-Calicheamicin)参考文献：

1.Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia.
Stasi R;Evangelista ML;Buccisano F;Venditti A;Amadori S Cancer Treat Rev. 2008 Feb;34(1):49-60. Epub 2007 Oct 17.

Gemtuzumab ozogamicin (GO) is a chemotherapeutic agent that consists of a humanized anti-CD33 antibody (hP67.6) linked to N-acetyl-calicheamicin 1,2-dimethyl hydrazine dichloride, a potent enediyne antitumor antibiotic. GO was approved conditionally by the Federal Drug Administration in May 2000 as single-agent therapy for first recurrence of acute myeloid leukemia (AML) in patients over the age of 60 years who are unfit for conventional cytotoxic therapy. In this setting, it produces a complete response (CR) rate of 13%, with another 13% achieving CR with inadequate platelet recovery (CRp). The most common adverse effects associated with GO are infusion-related reactions and myelosuppression. GO monotherapy at the dose of 9 mg/m(2) is complicated with hepatic veno-occlusive disease in approximately 5% of cases, particularly prior to or following stem cell transplantation. Attenuated doses of GO or fractionated doses appear to be equally effective and better tolerated. GO has shown remarkable activity in acute promyelocytic leukemia, particularly for the elimination of minimal residual disease. Combinations of GO with chemotherapy as induction or post-remission therapy are promising, and phase III trials are ongoing.

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