236102-87-7|Seco-Duocarmycin TM|Seco-Duocarmycin TM|-范德生物科技公司

Seco-Duocarmycin TM

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names：
Seco-Duocarmycin TM
CAS号：
236102-87-7
MDL Number：
MF(分子式)： C25H24N2O6 MW(分子量)： 448.47
EINECS: Reaxys Number:
Pubchem ID:10003785 Brand:BIOFOUNT

Seco-Duocarmycin TM(236102-87-7)是杜卡霉素家族的一种 DNA 烷化剂，可抑制 DNA 合成。Seco-Duocarmycin TM 是一种细胞毒性剂，用作抗体偶联药物中的细胞毒性成分。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000941-100mg	100mg	>95%	¥ 139654.00	¥ 139654.00		Backorder	- +	¥ 0.00
YZM000941-25mg	25mg	>95%	¥ 40346.00	¥ 40346.00		Backorder	- +	¥ 0.00

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中文别名	Seco-Duocarmycin TM(236102-87-7)
英文别名	Seco-Duocarmycin TM,236102-87-7
CAS号	236102-87-7
SMILES	OC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1
Inchi	InChI=1S/C25H24N2O6/c1-31-20-9-13-8-17(26-22(13)24(33-3)23(20)32-2)25(30)27-11-14(12-28)21-16-7-5-4-6-15(16)19(29)10-18(21)27/h4-10,14,26,28-29H,11-12H2,1-3H3/t14-/m0/s1
InchiKey	ITTCPQPHJURTKF-AWEZNQCLSA-N
分子式 Formula	C25H24N2O6
分子量 Molecular Weight	448.47
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

Seco-Duocarmycin TM(236102-87-7)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Seco-Duocarmycin TM(236102-87-7) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Seco-Duocarmycin TM(236102-87-7),Seco-Duocarmycin TM试剂,Seco-Duocarmycin TM抑制剂,Seco-Duocarmycin TM的作用,Seco-Duocarmycin TM的纯度,Seco-Duocarmycin TM的合成,Seco-Duocarmycin TM的生产,Seco-Duocarmycin TM的厂家

产品说明	Seco-Duocarmycin TM(236102-87-7)是杜卡霉素家族的一种 DNA 烷化剂，可抑制 DNA 合成。
Introduction	Seco-Duocarmycin TM (236102-87-7) is a DNA alkylating agent of the Dukamycin family, which can inhibit DNA synthesis.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA
Abstract:Both 5-hydroxy- and 5-amino-seco-CBI-TMI minor groove alkylators are very potent cytotoxins. The patterns of alkylation of the two enantiomers of both compounds were compared on a section of the gpt gene. All of the compounds alkylated only at adenines, with the amino compounds being slightly more selective. Consensus alkylation sequences for both S (natural) enantiomers were identical, but for the R (unnatural) enantiomers these varied slightly. The consensus sequences suggest that the S enantiomers bind lying in the 3'-->5' direction from the alkylated adenine, but there was no clear indication of which direction the R enantiomers lie on the DNA. Both S enantiomers were 10- to 100-fold more efficient alkylators than the R enantiomers, and the amino compounds were somewhat more efficient than the corresponding phenols. The S enantiomers were more cytotoxic then the R in both the phenol and amino series. The large amounts of end-labelled DNA required for this work was obtained by first end-labelling appropriate primer oligonucleotides, then amplifying by PCR. Compared with other methods in use, this is a simple and flexible one-step procedure for the preparation of labelled DNA of any sequence. An improvement in the synthesis of 5-hydroxy-seco-CBI-TMI is reported.

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