290304-24-4|Daun02|Daun02|MFCD22124459-范德生物科技公司

Daun02

NMR下载 COA and HPLC MSDS下载
names：
Daun02
CAS号：
290304-24-4
MDL Number： MFCD22124459
MF(分子式)： C41H44N2O20 MW(分子量)： 884.79
EINECS:No data available Reaxys Number:No data available
Pubchem ID:74891316 Brand:BIOFOUNT

Daun02(290304-24-4)使神经元整体失活会导致长期饮酒减少。此外，在CeA中注射Daun02的依赖动物体内的体细胞症状显著减少。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000903-5mg	5mg	98%	¥ 2835.00	¥ 2835.00		2-3天	- +	¥ 0.00
YZM000903-2mg	2mg	98%	¥ 1755.00	¥ 1755.00		2-3天	- +	¥ 0.00

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中文别名	Daun02(290304-24-4),Daun 02,Daun-02
英文别名	Daun02,290304-24-4
CAS号	290304-24-4
SMILES	O[C@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O)OC2=CC=C(C=C2[N+]([O-])=O)COC(N[C@@H]3[C@@H]([C@@H](O[C@H](C3)O[C@H]4C[C@](C(C)=O)(CC5=C(C(C(C6=C7C(OC)=CC=C6)=O)=C(C(O)=C54)C7=O)O)O)C)O)=O)CO
Inchi	InChI=1S/C41H44N2O20/c1-15-31(46)20(42-40(54)59-14-17-7-8-22(21(9-17)43(56)57)62-39-38(53)37(52)34(49)25(13-44)63-39)10-26(60-15)61-24-12-41(55,16(2)45)11-19-28(24)36(51)30-29(33(19)48)32(47)18-5-4-6-23(58-3)27(18)35(30)50/h4-9,15,20,24-26,31,34,37-39,44,46,48-49,51-53,55H,10-14H2,1-3H3,(H,42,54)/t15-,20-,24-,25+,26-,31+,34-,37-,38+,39+,41-/m0/s1
InchiKey	BOIXMGNMIWJAEW-LCTCPDETSA-N
分子式 Formula	C41H44N2O20
分子量 Molecular Weight	884.79
闪点 FP	636.3±34.3 °C
熔点 Melting point	No data available
沸点 Boiling point	1128.4±65.0 °C at 760 mmHg
Polarizability极化度	82.1±0.5 10-24cm3
密度 Density	1.7±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±0.3 mmHg at 25°C
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 100 mg/mL(113.02 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	棕色到酒红色固体粉末
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

Daun02(290304-24-4)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Daun02(290304-24-4) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Daun02(290304-24-4),Daun02试剂,Daun02抑制剂,Daun02的纯度,Daun02的作用,Daun02的外观,Daun02的溶解度,Daun02的效果,Daun02的合成,Daun02的应用,Daun02的结构式,Daun02的生产,Daun02的注意事项

产品说明	Daun02(290304-24-4)使神经元整体失活会导致长期饮酒减少,在CeA中注射Daun02的依赖动物体内的体细胞症状显著减少。
Introduction	Daun02 (290304-24-4) inactivation of neurons as a whole can lead to a reduction in long-term alcohol consumption, and the somatic withdrawal symptoms in dependent animals injected with Daun02 in CeA a
Application1	Daun02是拓扑异构酶抑制剂Daunorubicin的前药
Application2
Application3

Abstinence from alcohol is associated with the recruitment of neurons in the central nucleus of the amygdala (CeA) in nondependent rats that binge drink alcohol and in alcohol-dependent rats. However, whether the recruitment of this neuronal ensemble in the CeA is causally related to excessive alcohol drinking or if it represents a consequence of excessive drinking remains unknown. We tested the hypothesis that the recruitment of a neuronal ensemble in the CeA during abstinence is required for excessive alcohol drinking in nondependent rats that binge drink alcohol and in alcohol-dependent rats. We found that inactivation of the CeA neuronal ensemble during abstinence significantly decreased alcohol drinking in both groups. In nondependent rats, the decrease in alcohol intake was transient and returned to normal the day after the injection. In dependent rats, inactivation of the neuronal ensemble with Daun02 produced a long-term decrease in alcohol drinking. Moreover, we observed a significant reduction of somatic withdrawal signs in dependent animals that were injected with Daun02 in the CeA. These results indicate that the recruitment of a neuronal ensemble in the CeA during abstinence from alcohol is causally related to excessive alcohol drinking in alcohol-dependent rats, whereas a similar neuronal ensemble only partially contributed to alcohol-binge-like drinking in nondependent rats.

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护