2248666-66-0|PF429242 dihydrochloride|PF429242 dihydrochloride|No data available-范德生物科技公司

PF429242 dihydrochloride

NMR下载 COA and HPLC MSDS下载
names：
PF429242 dihydrochloride
CAS号：
2248666-66-0
MDL Number： No data available
MF(分子式)： C25H37Cl2N3O2 MW(分子量)： 482.49
EINECS:No data available Reaxys Number:No data available
Pubchem ID:90488837 Brand:BIOFOUNT

PF429242 dihydrochloride(2248666-66-0)是固醇调节元件结合蛋白（SREBP）位点1蛋白酶（IC50 = 0.175μM）的可逆竞争性抑制剂，是胆固醇，脂肪酸和葡萄糖代谢的转录调节剂。PF429242 dihydrochloride减少了小鼠肝脏中胆固醇和脂肪酸的合成。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000886-10mg	10mg	98.7%	¥ 1568.00	¥ 1568.00		2-3天	- +	¥ 0.00
YZM000886-5mg	5mg	98.7%	¥ 858.00	¥ 858.00		2-3天	- +	¥ 0.00

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询价

中文别名	PF429242 dihydrochloride(2248666-66-0),PF429242 (dihydrochloride),PF 429242 dihydrochloride
英文别名	PF429242 dihydrochloride,2248666-66-0,PF429242 (dihydrochloride),PF 429242 dihydrochloride
CAS号	2248666-66-0
SMILES	O=C(N(CCC1=CC=CC=C1OC)[C@H]2CNCC2)C3=CC=C(CN(CC)CC)C=C3.[H]Cl.[H]Cl
Inchi	InChI=1S/C25H35N3O2.2ClH/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3;;/h6-13,23,26H,4-5,14-19H2,1-3H3;2*1H/t23-;;/m1../s1
InchiKey	GSUZWFZKTIOWTI-MQWQBNKOSA-N
分子式 Formula	C25H37Cl2N3O2
分子量 Molecular Weight	482.49
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 83.3 mg/mL(172.65 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	白色至灰白色固体粉末
储藏条件 Storage conditions	在-20°C条件下保存3年,在4°C条件下保存2年

PF429242 dihydrochloride(2248666-66-0)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

PF429242 dihydrochloride(2248666-66-0) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	PF429242 dihydrochloride(2248666-66-0)是固醇调节元件结合蛋白（SREBP）位点1蛋白酶的可逆竞争性抑制剂
Introduction	PF429242 dihydrochloride (2248666-66-0) is a reversible competitive inhibitor of sterol regulatory element binding protein (SREBP) site 1 protease
Application1
Application2
Application3

10 μM PF-429242 inhibits endogenous SREBP processing in Chinese hamster ovary cells. PF-429242 also down-regulates the signal from an SRE-luciferase reporter gene in human embryonic kidney 293 cells and the expression of endogenous SREBP target genes in cultured HepG2 cells. In HepG2 cells, PF-429242 inhibits cholesterol synthesis, with an IC₅₀ of 0.5 μM. The addition of PF-429242 (30 μM) shows statistically significant suppression of infectious viral titers and viral RNA copies in the cell culture fluids. PF-429242 treatment also shows suppressive effects on DENV2 yields in the cultured fluids of human-derived HEK-293, Hep G2, and non-human-primate derived LLC-MK2 cells. PF-429242 efficiently prevents the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV, which correlates with the compound's potent antiviral activity against LCMV and LASV in cultured cells.

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护