932108-20-8|RSV604 R enantiomer|RSV604 R enantiomer|MFCD30536208-范德生物科技公司

RSV604 R enantiomer

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names：
RSV604 R enantiomer
CAS号：
932108-20-8
MDL Number： MFCD30536208
MF(分子式)： C22H17FN4O2 MW(分子量)： 388.39
EINECS:No data available Reaxys Number:No data available
Pubchem ID:5279171 Brand:BIOFOUNT

RSV604 R enantiomer(932108-20-8) 是 RSV604 的 R 型对映体。RSV604 抑制呼吸道合胞病毒 (RSV) 复制。而 RSV604 R enantiomer 微弱作用于 RSV。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000875-5mg	5mg	>95%	¥ 7080.00	¥ 7080.00		3-5周	- +	¥ 0.00
YZM000875-2mg	2mg	>95%	¥ 3412.00	¥ 3412.00		3-5周	- +	¥ 0.00

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中文别名	RSV604 R enantiomer(932108-20-8);RSV604 racemate;RSV604 (racemate)
英文别名	RSV604 R enantiomer(932108-20-8);RSV604 racemate;RSV604 (racemate)
CAS号	932108-20-8
SMILES	O=C1[C@H](NC(NC2=CC=CC=C2F)=O)N=C(C3=CC=CC=C3)C4=CC=CC=C4N1
Inchi	InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)/t20-/m0/s1
InchiKey	MTPVBMVUENFFLL-FQEVSTJZSA-N
分子式 Formula	C22H17FN4O2
分子量 Molecular Weight	388.39
闪点 FP	301.6±30.1 °C
熔点 Melting point	No data available
沸点 Boiling point	575.0±50.0 °C at 760 mmHg
Polarizability极化度	42.6±0.5 10-24cm3
密度 Density	1.3±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±1.6 mmHg at 25°C
溶解度Solubility
性状	固体粉末,Power
储藏条件 Storage conditions	在-20°C条件下保存3年,在4°C条件下保存2年

RSV604 R enantiomer(932108-20-8)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

RSV604 R enantiomer(932108-20-8) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:RSV604 R enantiomer(932108-20-8),RSV604 R enantiomer抑制剂,RSV604 R enantiomer的纯度,RSV604 R enantiomer试剂,RSV604 R enantiomer的外观,RSV604 R enantiomer的用途,RSV604 R enantiomer的合成,RSV604 R enantiomer的生产,RSV604 R enantiomer的溶解度

产品说明	RSV604 R enantiomer(932108-20-8) 是 RSV604 的 R 型对映体。RSV604是呼吸道合胞病毒（RSV）复制的抑制剂。
Introduction	RSV604 R enantiomer (932108-20-8) is the R enantiomer of RSV604. RSV604 is an inhibitor of respiratory syncytial virus (RSV) replication.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.

New strategies for control of respiratory syncytial virus infection

1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.
Abstract:Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as representing a serious threat to patient groups with poorly functioning or immature immune systems. Racemic 1,4-benzodiazepines show potent anti-RSV activity in vitro. Anti-RSV evaluation of 3-position R- and S-benzodiazepine enantiomers and subsequent optimization of this series resulted in selection of a clinical candidate. Antiviral activity was found to reside mainly in the S-enantiomer, and the R-enantiomers were consistently less active against RSV. Analogues of 1,4-(S)-benzodiazepine were synthesized as part of the lead optimization program at Arrow and tested in the XTT assay. From this exercise, (S)-1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)-urea, 17b (RSV-604) was identified as a clinical candidate, exhibiting potent anti-RSV activity in the XTT assay, which was confirmed in secondary assays. Compound 17b also possessed a good pharmacokinetic profile and has now progressed into the clinic.

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