37526-80-0|Melarsonyl|Melarsonyl|No data available-范德生物科技公司

Melarsonyl

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names：
Melarsonyl
CAS号：
37526-80-0
MDL Number： No data available
MF(分子式)： C13H13AsN6O4S2 MW(分子量)： 456.33
EINECS:No data available Reaxys Number:No data available
Pubchem ID:25908 Brand:BIOFOUNT

Melarsonyl (37526-80-0,Melarsonic acid) 是一种驱虫剂，Melarsonyl 可有效抑制寄生虫.

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000859-5mg	5mg	>95%	¥ 8100.00	¥ 8100.00		Backorder	- +	¥ 0.00
YZM000859-1mg	1mg	>95%	¥ 3900.00	¥ 3900.00		Backorder	- +	¥ 0.00

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询价

中文别名	Melarsonyl(37526-80-0);Melarsonic acid;Melarsonylum (acid);UNII-OOO8QR9Y40
英文别名	Melarsonyl,37526-80-0
CAS号	37526-80-0
SMILES	O=C(C1S[As](C2=CC=C(NC3=NC(N)=NC(N)=N3)C=C2)SC1C(O)=O)O
Inchi	InChI=1S/C13H13AsN6O4S2/c15-11-18-12(16)20-13(19-11)17-6-3-1-5(2-4-6)14-25-7(9(21)22)8(26-14)10(23)24/h1-4,7-8H,(H,21,22)(H,23,24)(H5,15,16,17,18,19,20)
InchiKey	LDILLULDEJXERI-UHFFFAOYSA-N
分子式 Formula	C13H13AsN6O4S2
分子量 Molecular Weight	456.33
闪点 FP	468.1±37.1 °C
熔点 Melting point	No data available
沸点 Boiling point	850.4±75.0 °C at 760 mmHg
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	0.0±0.3 mmHg at 25°C
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	Store in a cool and dry place

Melarsonyl (37526-80-0,Melarsonic acid)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Melarsonyl (37526-80-0,Melarsonic acid) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Melarsonyl (37526-80-0,Melarsonic acid),Melarsonyl 试剂,Melarsonyl 抑制剂,Melarsonyl 的纯度,Melarsonyl的作用,Melarsonyl的合成,Melarsonyl的外观,Melarsonyl的性质,Melarsonyl的含量,Melarsonyl的厂家,Melarsonyl 的生产

产品说明	Melarsonyl (37526-80-0,Melarsonic acid) 是一种驱虫剂，Melarsonyl ???????可有效抑制寄生虫.
Introduction	Melarsonyl (37526-80-0,Melarsonic acid) is an anthelmintic agent which can inhibitparasitepotently.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution
Abstract:Twelve new dithiaarsanes were evaluated for their in vitro and in vivo trypanocidal properties in regard to their three parent molecules, 4-amino-phenylarsenoxide, melarsenoxide, and 4-dansylamino-phenylarsenoxide. The most potent dithiaarsane, compound 2b, had a minimum effective concentration of 1.5 nM after 48 h of incubation and at a dose of 0.39 micromol/kg of body weight (0.2 mg/kg) administered subcutaneously cured 100% of mice acutely infected with Trypanosoma brucei brucei CMP. With this model, the chemotherapeutic index of compound 2b was 512, compared to 256 for melarsamine dihydrochloride (Cymelarsan) under the same conditions. With a chronic infection produced by T. brucei brucei GVR, compound 2b cured 100% of mice after treatment at a dose of 25 micromol/kg (12.5 mg/kg) for 4 consecutive days, whereas melarsamine dihydrochloride and potassium melarsonyl (Trimelarsan) cured less than 50% mice at this dose. For both acute and late-stage infections, dithiaarsanes having a melaminophenyl ring exhibited the most-potent trypanocidal activity. Compound 2b is thus one of the most active organoarsenicals described in a mouse trypanosomiasis model. Considering that the main intracellular targets of organoarsenicals are thiol groups, we studied the possibility of ligand exchange between Cymelarsan and several dithiols. In aqueous solution, we observed a rapid exchange of cysteamine from melarsamine with free cysteamine and also with various dithiols always in favor of more stable cyclic derivatives. These ligand exchanges suggest the ability of trivalent organoarsenicals to react with targets such as trypanothione and dihydrolipoic acid. Among several ligands, a 1,3-dimercaptopropane moiety appeared the most suitable for trypanocidal activity.

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