477-62-3|Isochondrodendrine|Isochondrodendrine|MFCD01734108-范德生物科技公司

Isochondrodendrine

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names：
Isochondrodendrine
CAS号：
477-62-3
MDL Number： MFCD01734108
MF(分子式)： C36H38N2O6 MW(分子量)： 594.7
EINECS: Reaxys Number:
Pubchem ID:197726 Brand:BIOFOUNT

Isochondrodendrine(477-62-3)是异喹啉和双苄基异喹啉生物碱的成员。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000835-5mg	5mg	>95%	¥ 0.00	¥ 0.00		Backorder	- +	¥ 0.00
YZM000835-1mg	1mg	>95%	¥ 0.00	¥ 0.00		Backorder	- +	¥ 0.00

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询价

中文别名	Isochondrodendrine(477-62-3);异粒枝碱;羟基箭毒碱
英文别名	Isochondrodendrine,477-62-3;Isobebeerine;Isobebeerin
CAS号	477-62-3
SMILES	OC1=C(OC2=CC=C(C=C2)C3)C4=C(C=C1OC)CCN(C)[C@]4([H])CC(C=C5)=CC=C5OC6=C(O)C(OC)=CC7=C6[C@]3([H])N(C)CC7
Inchi	InChI=1S/C36H38N2O6/c1-37-15-13-23-19-29(41-3)33(39)35-31(23)27(37)17-21-5-9-26(10-6-21)44-36-32-24(20-30(42-4)34(36)40)14-16-38(2)28(32)18-22-7-11-25(43-35)12-8-22/h5-12,19-20,27-28,39-40H,13-18H2,1-4H3
InchiKey	XIOGHHPVBVXQIV-UHFFFAOYSA-N
分子式 Formula	C36H38N2O6
分子量 Molecular Weight	594.7
闪点 FP	370.5±31.5 °C
熔点 Melting point	No data available
沸点 Boiling point	689.0±55.0 °C at 760 mmHg
Polarizability极化度	66.8±0.5 10-24cm3
密度 Density	1.2±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±2.2 mmHg at 25°C
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	存放在阴凉干燥处，短期（数天至数周）在0-4℃，长期（数月至数年）在-20℃。

Isochondrodendrine(477-62-3)毒性测试：

生物	测试类型	路线	报告剂量（标准化剂量）	影响	参考
mouse	LD50	intraperitoneal	1001 mg/kg (1001 mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX); LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Annales Pharmaceutiques Francaises., 7(569), 1949 [PMID:15401074]
mouse	LD50	subcutaneous	371 mg/kg (371 mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX); LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Annales Pharmaceutiques Francaises., 7(569), 1949 [PMID:15401074]

Isochondrodendrine(477-62-3)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Isochondrodendrine(477-62-3) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Isochondrodendrine(477-62-3),Isochondrodendrine试剂,Isochondrodendrine的纯度,Isochondrodendrine的杂质,Isochondrodendrine的外观,Isochondrodendrine的合成,Isochondrodendrine的MSDS,Isochondrodendrine的厂家,Isochondrodendrine的价格

产品说明	Isochondrodendrine(477-62-3)是一类从Isolona ghesquiereina中分离出来的双苄基异喹啉生物碱
Introduction	Isochondrodendrine(477-62-3) is a class of bisbenzylisoquinoline alkaloid isolated fromIsolona ghesquiereina.
Application1	Isochondodendrine has strong antiplasmodial activity againstPlasmodium falciparum.
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Biologically active bisbenzylisoquinoline alkaloids from the root bark of Epinetrum villosum PMID 15996841; Journal of ethnopharmacology 2005 Oct; 102(1):89-94

[Alkaloids of African Menispermaceae, Epinetrum cordifolium and Epinetrum mangenotii: isolation of cycleanine, norcycleanine and isochondrodendrine] PMID 5955797; Annales pharmaceutiques francaises 19

[Two novel bisbenzylisoquinoline alkaloids from Cyclea sutchuenensis Gagnep] PMID 8285068; Yao xue xue bao = Acta pharmaceutica Sinica 1993; 28(8):599-603

Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina PMID 10985080; Planta medica 2000 Aug; 66(6):537-40

New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia PMID 22230193; Fitoterapia 2012 Apr; 83(3):476-80

Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina
Abstract:From stem barks of Isolona guesquiereina three known bisbenzylisoquinolines were isolated and identified as (-)-curine, chondrofoline and isochondodendrine. Structures were established mainly on the basis of comparison of their physical and spectral data with published data for them and their methylated derivatives. Cleavage with sodium in liquid ammonia was necessary to unambiguously determine the stereochemistry of (-)-curine and subsequently establish its stereochemical link with chondrofoline, erroneously assigned as 7-O-methyl-(+)-curine. Complete and unambiguous 1H-, 15N- and 13C-NMR assignments of the three alkaloids were made by means of 2D-NMR techniques namely, COSY, HMQC, gs-HMQC, HMBC and NOESY. (-)-Curine, isochondrodendrine and their methylated derivatives were shown to exhibit strong in vitro antiplasmodial activity and in vivo activity was also observed for (-)-curine.

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