4758-99-0|Guanfu base H|Guanfu base H|-范德生物科技公司

Guanfu base H

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names：
Guanfu base H
CAS号：
4758-99-0
MDL Number：
MF(分子式)： C22H34ClNO2 MW(分子量)： 379.96
EINECS: Reaxys Number:
Pubchem ID:73388 Brand:BIOFOUNT

Guanfu base H(4758-99-0)是从Aconitum coreanum中分离出的一种二萜生物碱，对恶性疟原虫具有很强的抗疟原虫活性，对恶性疟原虫 TM4/8.2 菌株 (野生型) 和 K1CB1 菌株 IC₅₀ 值分别为 4 μM 和 3.6 μM。

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询价

中文别名	Guanfu base H(4758-99-0);Atisinium chloride;Atisine hydochloride
英文别名	Guanfu base H,4758-99-0
CAS号	4758-99-0
SMILES	O[C@H]1[C@]23[C@](C[C@@](CC3)([H])C1=C)([H])[C@]45[C@]([C@](C[N+](CCO)=C4)(CCC5)C)([H])CC2.[Cl-]
Inchi	InChI=1S/C22H34NO2/c1-15-16-4-8-21(19(15)25)9-5-17-20(2)6-3-7-22(17,18(21)12-16)14-23(13-20)10-11-24/h14,16-19,24-25H,1,3-13H2,2H3/q+1
InchiKey	RXGJFLXLQIECAN-UHFFFAOYSA-N
分子式 Formula	C22H34ClNO2
分子量 Molecular Weight	379.96
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	存放在阴凉干燥处，短期（数天至数周）在0-4℃，长期（数月至数年）在-20℃。

Guanfu base H(4758-99-0)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Guanfu base H(4758-99-0) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	Guanfu base H(4758-99-0)是从Aconitum coreanum中分离出的一种二萜生物碱，对恶性疟原虫具有很强的抗疟原虫活性
Introduction	Guanfu base H (4758-99-0) is a diterpene alkaloid isolated from Aconitum coreanum, which has strong anti-plasmodium activity against Plasmodium falciparum
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Antifeedant C20 diterpene alkaloids PMID 17191910; Chemistry & biodiversity 2004 Sep; 1(9):1327-35

Alkaloids from Delphinium staphisagria PMID 10978212; Journal of natural products 2000 Aug; 63(8):1136-9

Diterpenoid alkaloid derivatives as potential chemotherapeutic agents in American trypanosomiasis PMID 16391494; Pharmacology 2006; 76(3):123-8

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum PMID 20561926; Journal of ethnopharmacology 2010 Aug; 130(3):559-62

WU Qiong, et al. Simultaneous Determination of Guanfu Base A,Guanfu Base I and Guanfu Base H in Radix Aconitum coreanum(Lévl) Rapaics by RP-HPLC. Progress in Pharmaceutical Sciences. 2011, 35(5), 230-

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum
Ethnopharmacological relevance: The plant Aconitum orochryseum Stapf. (Ranunculaceae) is employed together with other plants in Bhutanese traditional medicine and is indicated for malaria-associated fever.
Aim of the study: To study the in vitro antiplasmodial activity of atisinium chloride, the major alkaloid from Aconitum orochryseum.
Materials and methods: Atisinium chloride was extracted and purified from aerial parts of Aconitum orochryseum and its structure and absolute configuration confirmed by single crystal X-ray crystallography. The crude methanol extract, crude alkaloid fraction, and atisinium chloride were tested for in vitro antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (TM4; wild type) and K1CB1 (K1; chloroquine and antifolate resistant).
Results: The diterpenoid alkaloid atisinium chloride was shown to have moderate antiplasmodial activities with IC(50) values of 4 microM and 3.6 microM, respectively against the TM4 strain and the K1 strain of Plasmodium falciparum.
Conclusions: Our studies provide the first evidence in support of one of the indicated treatments with Aconitum orochryseum in Bhutanese traditional medicine. This alkaloid also represents a potential new antimalarial structural lead.

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