91433-17-9|甘草黄酮B|Licoflavone B|-范德生物科技公司

甘草黄酮B

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names：
Licoflavone B
CAS号：
91433-17-9
MDL Number：
MF(分子式)： C25H26O4 MW(分子量)： 390.47
EINECS: Reaxys Number:
Pubchem ID:11349817 Brand:BIOFOUNT

甘草黄酮B(91433-17-9,Licoflavone B)是一种从黄草甘草中分离出来的类黄酮，甘草黄酮B可以抑制血吸虫的活性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000828-5mg	5mg	>95%	¥ 3402.00	¥ 3402.00		Backorder	- +	¥ 0.00
YZM000828-1mg	1mg	>95%	¥ 1092.00	¥ 1092.00		Backorder	- +	¥ 0.00

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中文别名	甘草黄酮B(91433-17-9,Licoflavone B)
英文别名	Licoflavone B(91433-17-9);Prenyllicoflavone A
CAS号	91433-17-9
SMILES	O=C1C=C(C2=CC=C(O)C(C/C=C(C)\C)=C2)OC3=CC(O)=C(C/C=C(C)\C)C=C13
Inchi	InChI=1S/C25H26O4/c1-15(2)5-7-17-11-19(9-10-21(17)26)24-14-23(28)20-12-18(8-6-16(3)4)22(27)13-25(20)29-24/h5-6,9-14,26-27H,7-8H2,1-4H3
InchiKey	GLDVIKFETPAZNV-UHFFFAOYSA-N
分子式 Formula	C25H26O4
分子量 Molecular Weight	390.47
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	No data available
密度 Density	No data available
蒸汽压 Vapor Pressure	No data available
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	存放在阴凉干燥处，短期（数天至数周）在0-4℃，长期（数月至数年）在-20℃。

甘草黄酮B(91433-17-9,Licoflavone B)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Licoflavone B(91433-17-9) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	甘草黄酮B(91433-17-9,Licoflavone B)是一种从黄草甘草中分离出来的类黄酮，甘草黄酮B可以抑制血吸虫的活性。
Introduction	Licoflavone B (91433-17-9, 甘草黄酮B) is a flavonoid isolated from yellow licorice root. Licorice flavone B can inhibit the activity of schistosomes.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Pharmacological Activities and Phytochemical Constituents(Liquorice,2017)

Synthesis of 6,7-Dibromoflavone and Its Regioselective Diversification via Suzuki–Miyaura Reactions(Synthesis,2017)

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae) PMID 32106571; Biomolecules 2020 Feb; 10(3): (Review Article)

Chemical studies of Chinese licorice-roots. I. Elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra L. collected in Xinjiang PMID 8069956; Chemical & pharmaceutical bull

Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae) PMID 26454044; Experimental parasitology 2015 Dec; 159(?):207-14

Schistosomicidal activity and docking of Schistosoma mansoni ATPDase 1 with licoflavone B isolated from Glycyrrhiza inflata (Fabaceae)
Abstract:Schistosomiasis is one of the world's major public health problems, and its treatment is widely dependent on praziquantel (PZQ), the only available drug. Schistosoma mansoni ATP diphosphohydrolases are ecto-enzymes localized on the external tegumental surface of S. mansoni and considered an important target for action of new drugs. In this work, the in vitro schistosomicidal activity of the crude extract of Glycyrrhiza inflata roots (GI) and its isolated compounds echinatin, licoflavone A and licoflavone B were evaluated against S. mansoni adult worms. Results showed that GI (200 μg/mL) was active against adult schistosomes, causing 100% mortality after 24 h of incubation. Chromatographic fractionation of GI led to isolation of echinatin, licoflavone A and licoflavone B. Licoflavone B (25-100 μM) caused 100% mortality, tegumental alterations, and reduction of oviposition and motor activity of all adult worms, without affecting mammalian Vero cells. Confocal laser scanning microscopy showed tegumental morphological alterations and changes on the numbers of tubercles of S. mansoni worms in a dose-dependent manner after incubation with licoflavone B. Licoflavone B also showed high S. mansoni ATPase (IC50 of 23.78 μM) and ADPase (IC50 of 31.50 μM) inhibitory activities. Docking studies predicted different interactions between licoflavone B and S. mansoni ATPDase 1, corroborating with the in vitro inhibitory activity. This report demonstrated the first evidence for the schistosomicidal activity of licoflavone B and suggests that its mechanism of action involve the inhibition of S. mansoni ATP diphosphohydrolases.

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