13752-33-5|帕硝唑|Panidazole|MFCD00866604-范德生物科技公司

帕硝唑

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names：
Panidazole
CAS号：
13752-33-5
MDL Number： MFCD00866604
MF(分子式)： C11H12N4O2 MW(分子量)： 232.24
EINECS:237-334-3 Reaxys Number:
Pubchem ID:72080 Brand:BIOFOUNT

帕硝唑(13752-33-5,Panidazole)是一种5-硝基咪唑衍生物，是一种杀虫剂，对体外溶血性变形杆菌和阴道毛滴虫显示出有效的体外活性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000822-5mg	5mg	99.6%	¥ 2025.00	¥ 2025.00		2-3天	- +	¥ 0.00
YZM000822-1mg	1mg	99.6%	¥ 975.00	¥ 975.00		2-3天	- +	¥ 0.00

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中文别名	帕硝唑(13752-33-5,Panidazole);甲硝咪乙啶
英文别名	Panidazole(13752-33-5)
CAS号	13752-33-5
SMILES	O=[N+](C1=CN=C(C)N1CCC2=CC=NC=C2)[O-]
Inchi	InChI=1S/C11H12N4O2/c1-9-13-8-11(15(16)17)14(9)7-4-10-2-5-12-6-3-10/h2-3,5-6,8H,4,7H2,1H3
InchiKey	ARYPMCPJIWUCIP-UHFFFAOYSA-N
分子式 Formula	C11H12N4O2
分子量 Molecular Weight	232.24
闪点 FP	239.0±24.6 °C
熔点 Melting point	108-111 ℃
沸点 Boiling point	471.6±30.0 °C at 760 mmHg
Polarizability极化度	25.2±0.5 10-24cm3
密度 Density	1.3±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±1.1 mmHg at 25°C
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 125 mg/mL(538.24 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	白色至灰白色固体粉末
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 /溶液中:-80°C 6 months月 -20°C 1 month月

帕硝唑(13752-33-5,Panidazole)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

Panidazole(13752-33-5) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Panidazole(13752-33-5),Panidazole试剂,Panidazole抑制剂,Panidazole的作用,Panidazole的纯度,Panidazole的合成,Panidazole的生产,Panidazole的含量,Panidazole的使用,Panidazole的厂家,Panidazole的外观,Panidazole的MSDS,Panidazole的注意事项

产品说明	帕硝唑(13752-33-5,Panidazole)是一种5-硝基咪唑衍生物，是一种杀虫剂，对体外溶血性变形杆菌和阴道毛滴虫显示出有效的体外活性。
Introduction	Panidazole(13752-33-5,帕硝唑), a 5-nitroimidazole derivative, is an amoebicide that showed potent in vitro activity against Entamoeba histolytica and Trichomonas vaginalis.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

1-(2-(γ-Pyridyl)ethyl)-2-methyl-5-nitro-imidazole (Panidazole), A new amoebicide(Experientia,1970)

Cross-resistance of trichomonads to 5-nitroimidazole-derivatives(Experientia,1976)

The Pharmacology and Toxicology of 5-Nitroimidazoles(Nitroimidazoles,1982)

Resistance to 5-Nitroimidazoles in Pathogenic Microorganisms(Nitroimidazoles,1982)

Blastocystis hominis: neutral red supravital staining and its application to in vitro drug sensitivity testing(Parasitology Research,2000)

Botero D, et al. Treatment of intestinal amoebiasis and vaginal trichomoniasis with panidazole and its comparison with metronidazole. Trans R Soc Trop Med Hyg. 1977;71(6):508-11.
Abstract:A dose range study in 18 patients suffering from intestinal amoebiasis and treated with doses of panidazole between 1.0 and 2.0 g per day for six days revealed that the best therapeutic results were obtained with the higher dose. This dose was then compared with metronidazole, at the same dose, in a clinical trial in 100 patients with intestinal amoebiasis. Cure rates were 68% and 80% for the two drugs respectively. In 100 cases of vaginal trichomoniasis treated with panidazole at the dose of 1.0 g per day for seven days in half of the patients and for 10 days in the other half, we obtained 50% and 60% cure rates. The results of our studies with both amoebiasis and trichomoniasis were not superior to those obtained with metronidazole and other nitroimidazole derivatives. Side effects were found in 74% of the patients treated for amoebiasis and in 46% of the cases treated for trichomoniasis. No toxic effects were revealed by haematological, biochemical and renal function tests nor by cardiovascular studies.

Voogd CE, et al. The mutagenic action of nitroimidazoles. II. Tinidazole, ipronidazole, panidazole and ornidazole. Mutat Res. 1977 Apr;48(2):155-61.
Abstract:The 5-nitroimidazoles tinidazole (Fasigyn), ipronidazole (Ro-7-1554), panidazole and ornidazole (Tiberal, Ro-7-0207) in concentrations of 0.02--1 mM per liter increased the mutation frequency of Klebsiella pneumoniae. Escherichia coli K12 and Citrobacter freundii to streptomycin resistance, including streptomycin dependence, in Luria and Delbrück's fluctuation test. At low concentration (0.1 mM), the increase of the mutation frequency caused by each compound was nearly the same, i.e. 3--4 times the spontaneous mutation frequency. At higher concentrations, considerable differences between the mutagenic activities of the compounds occurred.

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