3374-88-7|ICA|ICA|MFCD00642222-范德生物科技公司

ICA

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names：
ICA
CAS号：
3374-88-7
MDL Number： MFCD00642222
MF(分子式)： C13H10N4S MW(分子量)： 254.31
EINECS: Reaxys Number:
Pubchem ID:772885 Brand:BIOFOUNT

ICA(3374-88-7)是SK通道 (SK channel) 抑制剂。ICA有抗利什曼原虫活性

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000799-5mg	5mg	99.6%	¥ 4556.00	¥ 4556.00		2-3天	- +	¥ 0.00
YZM000799-1mg	1mg	99.6%	¥ 1462.00	¥ 1462.00		2-3天	- +	¥ 0.00

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询价

中文别名	ICA(3374-88-7);TCMDC-124275;GNF-PF-4773;Pyridin-2-yl-(4-pyridin-2-yl-thiazol-2-yl)-amine
英文别名	ICA,3374-88-7
CAS号	3374-88-7
SMILES	C1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1
Inchi	InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
InchiKey	RYCUBTFYRLAMFA-UHFFFAOYSA-N
分子式 Formula	C13H10N4S
分子量 Molecular Weight	254.31
闪点 FP	235.9±29.6 °C
熔点 Melting point	No data available
沸点 Boiling point	466.4±48.0 °C at 760 mmHg
Polarizability极化度	28.9±0.5 10-24cm3
密度 Density	1.3±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±1.2 mmHg at 25°C
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 49.5 mg/mL(194.64 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	浅棕色至棕色固体粉末
储藏条件 Storage conditions	storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)

ICA(3374-88-7)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染

ICA(3374-88-7) Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:ICA(3374-88-7),ICA试剂,ICA抑制剂,ICA的纯度,ICA的作用,ICA的外观,ICA的合成,ICA的用途,ICA的厂家,ICA的溶解度,ICA的价格,ICA的生产,ICA的MSDS,ICA的使用,ICA的注意事项

产品说明	ICA(3374-88-7)是SK通道 (SK channel) 抑制剂。ICA有抗利什曼原虫活性
Introduction	ICA (3374-88-7) is an SK channel inhibitor. ICA has anti-leishmania activity
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Antiarrhythmic effect of the Ca2+-activated K+ (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation

Pharmacological blockade of small conductance Ca2+-activated K+ channels by ICA reduces arrhythmic load in rats with acute myocardial infarction

Theory of magnetism close to the5\nT\n2 —1\nA\n1 crossover in iron(II) complexes(Theoretica chimica acta,1971)

Magnetic properties of iron(II) complex with 2-(pyridin-2-ylamino)-4-(pyridin-2-yl)thiazole(Magnetic Properties of Paramagnetic Compounds,2017)

Small-conductance Ca2+-activated K+ channels: insights into their roles in cardiovascular disease(Experimental & Molecular Medicine,2018)

Towards Control of the Intrinsic Characteristics of Spin-Crossover in Ferrous Materials
Abstract:Metal complexes exhibiting spin-crossover between low-spin (LS) and high-spin (HS) electronic states have been recognized since Cambi, Szegö and Cagnasso first observed “magnetic isomerism” for tris(dithiocarbamato) iron(III) complexes in 1931 [1]. Today, about 100 spin-crossover systems are known and the field has developed into an important area of contemporary coordination chemistry spanning from theory to applications and based upon ligand design and elaborated physicochemical studies of the resulting complexes.

Spin transition in iron(II) complexes induced by heat, pressure, light, and nuclear decay
Abstract:The phenomenon of temperature-dependent spin transition will be introduced and the numerous chemical and physical influences affecting the spin transition characteristics will be discussed. We shall mainly concentrate on the spin crossover system [Fe(2-pic)3]X2·Sol (2-pic=2-aminomethylpyridine; X=Cl, Br; Sol=C2H5OH, CH3OH) and demonstrate how the behaviour of the spin transition5T2g(Oh)?1A1g(Oh) is influenced by substituting the metalion, the non-coordinating anions X, the crystal solvent molecules Sol and by isotopic exchange with H/D and14N/15N. It will also be shown that the spin transition is very susceptible to pressure. A quantitative spin state conversion from low spin to high spin can also be achieved by illuminating the crystals of a spin crossover system at sufficiently low temperatures. The metastable quintet state can be trapped with practically infinite lifetimes. Several examples for this “Light-Induced Excited Spin State Trapping” (LIESST) will be given. Finally, the occurrence of short-lived anomalous spin quintet states following the57Co(EC)57Fe nuclear decay, which have been observed in the Mössbauer emission spectra of57Co-doped complex compounds, will be discussed with particular references to the LIESST effect.

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