艾默德斯

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names：
Emodepside
CAS号：
155030-63-0
MDL Number： MFCD09837720
MF(分子式)： C60H90N6O14 MW(分子量)： 1119.39
EINECS:No data available Reaxys Number:155030-63-0
Pubchem ID:5293825 Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000789-10mg	10mg	>98.0%	¥ 2835.00	¥ 2835.00		2-3天	- +	¥ 0.00
YZM000789-5mg	5mg	>98.0%	¥ 1755.00	¥ 1755.00		2-3天	- +	¥ 0.00

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中文别名	艾默德斯(Emodepside,155030-63-0)
英文别名	Emodepside(艾默德斯,155030-63-0）
CAS号	155030-63-0
SMILES	O=C(N([C@H](C(O[C@](C(N([C@H](C(O[C@H](CC1=CC=C(N2CCOCC2)C=C1)C(N(C)[C@H](CC(C)C)C(O[C@H](C)C(N(C)[C@@H](CC(C)C)C3=O)=O)=O)=O)=O)CC(C)C)C)=O)([H])C)=O)CC(C)C)C)[C@H](O3)CC4=CC=C(N5CCOCC5)C=C4
Inchi	InChI=1S/C60H90N6O14/c1-37(2)31-47-57(71)77-41(9)53(67)61(11)50(34-40(7)8)60(74)80-52(36-44-17-21-46(22-18-44)66-25-29-76-30-26-66)56(70)64(14)48(32-38(3)4)58(72)78-42(10)54(68)62(12)49(33-39(5)6)59(73)79-51(55(69)63(47)13)35-43-15-19-45(20-16-43)65-23-27-75-28-24-65/h15-22,37-42,47-52H,23-36H2,1-14H3/t41-,42-,47+,48+,49+,50+,51-,52-/m1/s1
InchiKey	ZMQMTKVVAMWKNY-YSXLEBCMSA-N
分子式 Formula	C60H90N6O14
分子量 Molecular Weight	1119.39
闪点 FP	691.2±34.3 °C
熔点 Melting point	No data available
沸点 Boiling point	1219.3±65.0 °C at 760 mmHg
Polarizability极化度	118.9±0.5 10-24cm3
密度 Density	1.1±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±0.3 mmHg at 25°C
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 31 mg/mL(27.69 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	固体粉末,Power
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

艾默德斯(Emodepside,155030-63-0)毒性：

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	unreported	> 1600mg/kg (1600mg/kg)	Journal of Medicinal Chemistry. Vol. 18, Pg. 1164, 1975.
mouse	LD50	unreported	> 6400mg/kg (6400mg/kg)	Journal of Medicinal Chemistry. Vol. 18, Pg. 1164, 1975.
rat	LD50	unreported	> 6400mg/kg (6400mg/kg)	Journal of Medicinal Chemistry. Vol. 18, Pg. 1164, 1975.

艾默德斯(Emodepside,155030-63-0)物理性质：

Physical Property	Value	Units	Temp (deg C)	Source
Melting Point	253 dec	deg C		EXP
log P (octanol-water)	1.630	(none)		EST
Atmospheric OH Rate Constant	1.07E-10	cm3/molecule-sec	25	EST

艾默德斯(Emodepside,155030-63-0)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	它具有杀虫药的作用。它是半合成衍生物和环八肽肽。
Introduction	Emodepside (PF 102221) is a cyclooctadepsipeptide with broadpectrum anthelmintic activity.
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Worms take to the slo lane: a perspective on the mode of action of emodepside Invertebrate Neuroscience 2012/PMID: 22539031

Mechanisms of action of emodepside Parasitology Research 2005/PMID: 16228263

Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats Parasitology Research 2005/PMID: 16228275

Field evaluation of the efficacy and safety of emodepside/praziquantel spot–on solution against naturally acquired nematode and cestode infections in domestic cats Parasitology Researc/PMID: 16228276

Field Evaluation of the Efficacy and Safety of Emodepside plus Praziquantel Tablets (Profender? Tablets for Dogs) against Naturally Acquired Nematode and Cestode Infections in Dogs Par/PMID: 19575222

Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Trichuris vulpis infections in dogs

Abstract

This paper reports on the efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult whipworms (Trichuris vulpis) at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight in dogs. Three randomised, blinded and controlled laboratory studies with naturally or experimentally infected dogs were performed. The first study was conducted as a dose determination study in experimentally infected dogs using three different dose levels, i.e., 0.5x, 1x and 2x the minimum therapeutic dose. Two further studies confirmed the efficacy of emodepside plus praziquantel tablets against mature and immature adult T. vulpis at the recommended minimum dose. In all three studies, the efficacy against mature and immature adult T. vulpis was >99%. No side effects of the treatment were observed. It is concluded that the emodepside plus praziquantel tablet is an effective and safe treatment against mature and immature adult stages of T. vulpis in dogs.

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