141368-69-6|基质蛋白M1(58-66)(甲型流感病毒)|CEF1, Influenza Matrix Protein M1 58-66|-范德生物科技公司

基质蛋白M1(58-66)(甲型流感病毒)

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names：
CEF1, Influenza Matrix Protein M1 58-66
CAS号：
141368-69-6
MDL Number：
MF(分子式)： C49H75N9O11 MW(分子量)： 966.17
EINECS: Reaxys Number:
Pubchem ID:446076 Brand:BIOFOUNT

基质蛋白M1(58-66)(甲型流感病毒)CEF1, Influenza Matrix Protein M1 58-66(141368-69-6)是源自甲型流感病毒基质蛋白的表位。

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中文别名	基质蛋白M1(58-66)(甲型流感病毒)(141368-69-6);CEF1，流感基质蛋白M1（58-66）;基质蛋白M1（58-66）（甲型流感病毒）;CHEMBL1869460;HY-P0137;ZINC150355093;NCGC00167248-01;CS-0019779;基质蛋白M1（58-66）（甲型流感病毒);基质蛋白M1（58-66）（流感病毒）；H-甘氨酸-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU-OH; H2N-GILGFVFTL-OH；GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU 流感基质肽; INFLUENZA MATRIX蛋白质M1（58-66）；流感病毒基质蛋白（58-66）; GILGFVFTL;
英文别名	CEF1, Influenza Matrix Protein M1 58-66(141368-69-6); CEF1, Influenza Matrix Protein M1 (58-66);Matrix Protein M1 (58-66) (Influenza A virus);CHEMBL1869460;HY-P0137;ZINC150355093;NCGC00167248-01;CS-0019779;Matrix protein m1(58-66)(influenza a virus); MATRIX PROTEIN M1 (58-66) (INFLUENZA A VIRUS); H-GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU-OH; H2N-GILGFVFTL-OH; GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU; INFLUENZA MATRIX PEPTIDE; INFLUENZA MATRIX PROTEIN M1 (58-66); INFLUENZA VIRUS MATRIX PROTEIN (58-66); GILGFVFTL;
CAS号	141368-69-6
SMILES	CCC(C)C(C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)O)
Inchi	InChI=1S/C49H75N9O11/c1-10-30(8)41(56-38(60)25-50)47(66)53-34(21-27(2)3)43(62)51-26-39(61)52-35(23-32-17-13-11-14-18-32)44(63)57-40(29(6)7)46(65)54-36(24-33-19-15-12-16-20-33)45(64)58-42(31(9)59)48(67)55-37(49(68)69)22-28(4)5/h11-20,27-31,34-37,40-42,59H,10,21-26,50H2,1-9H3,(H,51,62)(H,52,61)(H,53,66)(H,54,65)(H,55,67)(H,56,60)(H,57,63)(H,58,64)(H,68,69)/t30-,31+,34-,35-,36-,37-,40-,41-,42-/m0/s1
InchiKey	NBDRFCQNHCTWII-CXECYRLYSA-N
分子式 Formula	C49H75N9O11
分子量 Molecular Weight	966.17
闪点 FP	748.2±34.3°摄氏度
熔点 Melting point	No data available
沸点 Boiling point	1313.5±65.0°C在760毫米汞柱
Polarizability极化度
密度 Density	1.2±0.1克/厘米3
蒸汽压 Vapor Pressure	25°C时为0.0±0.3 mmHg
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	请根据产品建议的存储条件进行存储,Please store the product under the recommended condition sin the description.

基质蛋白M1(58-66)(甲型流感病毒)CEF1, Influenza Matrix Protein M1 58-66(141368-69-6)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

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产品说明	基质蛋白M1(58-66)(甲型流感病毒)CEF1, Influenza Matrix Protein M1 58-66(141368-69-6)是源自甲型流感病毒基质蛋白的表位
Introduction	基质蛋白M1(58-66)(甲型流感病毒)CEF1, Influenza Matrix Protein M1 58-66(141368-69-6) is an epitope derived from the matrix protein of the influenza A virus.
Application1
Application2
Application3

基质蛋白M1(58-66)(甲型流感病毒)CEF1, Influenza Matrix Protein M1 58-66(141368-69-6)药理学：

基质蛋白M1(58-66)(甲型流感病毒)CEF1, Influenza Matrix Protein M1 58-66(141368-69-6)是源自甲型流感病毒基质蛋白的表位。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Petrova GV, et al. Cross-reactive responses to modified M1 peptides by CD8? T cells that use noncanonical BV genes can describe unknown repertoires. Eur J Immunol. 2012 Nov;42(11):3001-8.

基质蛋白M1(58-66)(甲型流感病毒)CEF1, Influenza Matrix Protein M1 58-66(141368-69-6)参考文献：

1、Cross-reactive responses to modified M1 peptides by CD8 T cells that use noncanonical BV genes can describe unknown repertoires
Galina V Petrova 1, Jack Gorski

Abstract Memory T-cell repertoires are populated by clonotypes selected by an individual's history of antigen exposures. Our previous analysis of middle-age CD8(+) T-cell memory repertoires to the influenza-derived epitope M1(58-66) , described a network of highly cross-reactive BV19 clonotypes responding to M1(58-66) and at least one peptide with a conservative amino acid substitution at either of two TCR contact positions. Here, we report that some substitutions abrogate BV19 responses and favor responses with different BV. Cross-reactive T cells using seven other BV families responded to 12 of 13 peptides tested. BV12 clonotypes define the most extensive cross-reactive network that encompasses seven peptides. We generated 3D networks based on the peptides recognized and BV family used and observed a cluster of five peptides that includes M1(58-66) and another cluster of five peptides that does not include M1(58-66) . The first cluster represents peptides structurally similar to M1(58-66) , and the second represents peptides with more considerable changes in epitope recognition surface. We hypothesize that the second cluster represents the cross-reactive network around another unknown epitope or epitopes. This data supports a model of stable CD8(+) T-cell memory networks that include a substantial contribution from cross-reactive T cells.

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