615253-61-7|SP187|SP187|MFCD28502268-范德生物科技公司

SP187

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names：
SP187
CAS号：
615253-61-7
MDL Number： MFCD28502268
MF(分子式)： C16H33NO5 MW(分子量)： 319.44
EINECS: Reaxys Number:
Pubchem ID:503982 Brand:BIOFOUNT

SP187(615253-61-7,SP187,MON-DNJ,UV4)是针对宿主的亚氨基糖，在体外和体内均具有抗丝状病毒感染的活性。SP187在体内具有抗流感和登革热的活性。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000733-5mg	5mg	99.3%	¥ 6075.00	¥ 6075.00		Backorder	- +	¥ 0.00
YZM000733-1mg	1mg	99.3%	¥ 2925.00	¥ 2925.00		2-3天	- +	¥ 0.00

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中文别名	SP187(615253-61-7);MON-?DNJ; UV4;(2R，3R，4R，5S）-2-（羟甲基）-1-（9-甲氧基壬基）哌啶-3,4,5-三醇; N-9-甲氧壬基脱氧野oji霉素; SP-187；SP187; SP 187；N-9-DNJ；UV-4B；N9DNJ；UV4B；N 9 DNJ；紫外线4B;
英文别名	SP187(615253-61-7);(2R,3R,4R,5S)-2-(hydroxymethyl)-1-(9-methoxynonyl)piperidine-3,4,5-triol; N-9-Methoxynonyldeoxynojirimycin; SP-187; SP187; SP 187; N-9-DNJ; UV-4B; N9DNJ; UV4B; N 9 DNJ; UV 4B;
CAS号	615253-61-7
SMILES	OC[C@H]1N(C[C@H](O)[C@@H](O)[C@@H]1O)CCCCCCCCCOC
Inchi	InChI = 1S / C16H33NO5 / c1-22-10-8-6-4-2-3-5-7-9-17-11-14（19）16（21）15（20）13（17）12- 18 / h13-16,18-21H，2-12H2,1H3 / t13-，14 +，15-，16- / m1 / s1
InchiKey	TYTARGBBJQKLAJ-QKPAOTATSA-N
分子式 Formula	C16H33NO5
分子量 Molecular Weight	319.44
闪点 FP	241.1±27.3°摄氏度
熔点 Melting point	No data available
沸点 Boiling point	760毫米汞柱时475.0±40.0°C
Polarizability极化度
密度 Density	1.1±0.1克/厘米3
蒸汽压 Vapor Pressure	25°C时为0.0±2.7 mmHg
溶解度Solubility
性状	固体粉末,Power
储藏条件 Storage conditions	存放在阴凉干燥处，-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

SP187(615253-61-7,SP187,MON-DNJ,UV4)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:SP187试剂,SP187杂质,SP187中间体,SP187密度,SP187旋光度,SP187溶解度,SP187合成,SP187闪点,SP187购买,SP187MSDS,

产品说明	SP187(615253-61-7,SP187,MON-DNJ,UV4) 是针对宿主的亚氨基糖,在体外和体内均具有抗丝状病毒感染的活性。
Introduction	SP187(615253-61-7,SP187,MON-DNJ,UV4)is a hostargeted iminosugar with activity against filovirus infections in vitro and in vivo. SP187 is active against influenza and dengue in vivo.
Application1	SP187在体内具有抗流感和登革热的活性。
Application2
Application3

SP187(615253-61-7,SP187,MON-DNJ,UV4)药理学：

SP187，也称为N-9-DNJ和UV-4B，是一种针对宿主的亚氨基糖，在体外和体内均具有抗丝状病毒感染的活性，可用于治疗登革热和流感感染。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

SP187(615253-61-7,SP187,MON-DNJ,UV4)危害标识：

Warfield KL, et al. Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo. Antiviral Res. 2017 Feb;138:22-31.

Proline-hyperproducing strains of Serratia marcescens: enhancement of proline analog-mediated growth inhibition by increasing osmotic stress PMID 2860849; Applied and environmental microbiology 1985 A

A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies PMID 7527817; Journal of immunology (Baltimore, Md. : 19

SP187(615253-61-7,SP187,MON-DNJ,UV4)参考文献：

1.A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies.
Baba E;Nakamura M;Ohkuma K;Kira J;Tanaka Y;Nakano S;Niho Y J Immunol. 1995 Jan 1;154(1):399-412.

We have recently identified the principal linear neutralizing B cell epitopes of human T cell leukemia virus type I (HTLV-I) on the envelope protein gp46, amino acids (aa) 187-199, by using a number of human mAbs. We therefore propose that this region would be a good candidate for a peptide-based HTLV-I vaccine. To develop a peptide-based vaccine that can induce a high titer of neutralizing Abs against HTLV-I, we first synthesized peptides of various lengths containing aa187-199. Because the addition of gp46 aa181-186 or aa200-210 to either the N-terminus or C-terminus of SP187-199 did not alter the antigenicity of the principal neutralizing determinant, we prepared two peptide-based vaccines, MAP181-203 and MAP181-210, by conjugating SP181-203 and SP181-210 with a branched polylysine oligomer. In rabbits, X4 to X8 and X8 to X64 titers of the neutralizing Abs were induced by immunization with MAP181-203 and MAP181-210, respectively. Furthermore, high titers of neutralizing Abs (X40 to X320) were elicited in five different strains of rats by immunization with MAP181-210. We also identified the major T cell epitope on gp46 aa194-210 in various strains of rats immunized with MAP181-210.

2.Proline-hyperproducing strains of Serratia marcescens: enhancement of proline analog-mediated growth inhibition by increasing osmotic stress.
Sugiura M;Kisumi M Appl Environ Microbiol. 1985 Apr;49(4):782-6.

Proline-producing strains of Serratia marcescens were more osmotolerant than wild-type strains. Growth inhibition by proline analogs was significantly enhanced by increasing the osmotic stress of the medium. Mutants resistant to azetidine-2-carboxylate were derived from a proline-producing strain, SP126, under a high osmotic condition. One of the mutants, strain SP187, produced 56 mg of L-proline per ml of medium containing sucrose and urea. This amount was ca. 3 times larger than that produced by strain SP126. The intracellular glutamate content which decreased in strain SP126 was restored in strain SP187. The glutamate dehydrogenase level of strain SP187 was 5 times higher than that of strain SP126.

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