111687-37-7|HSV-TK底物|HSV-TK substrate|-范德生物科技公司

HSV-TK底物

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names：
HSV-TK substrate
CAS号：
111687-37-7
MDL Number：
MF(分子式)： C11H15N5O4 MW(分子量)： 281.27
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

HSV-TK底物(111687-37-7,HSV-TK substrate)是HSV-TK的底物，并在表达HSV-T K和旁观者细胞中诱导多对数细胞毒性，具有抗肿瘤活性。

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中文别名	HSV-TK底物(111687-37-7);2-氨基-9-[（（1R，2S，3R，4R）-2,3-二羟基-4-（羟甲基）环戊基] -1,9-二氢-6H-嘌呤-6-; D-碳环-2'-脱氧鸟苷;
英文别名	HSV-TK substrate(111687-37-7);HSV-TK SUBSTRATE;(1R,2S,3R,4R)-2-Amino-9-(2,3-dihydroxy-4-hydroxymethylcyclopentyl)-1,9-dihydropurin-6-one; 2-amino-9-((1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl)-1H-purin-6(9H)-one; 2-amino-9-(2,3-dihydroxy-4-hydroxymethyl-cyclopentyl)-1,9-dihydro-purin-6-one; 2-Amino-9-((1R,2S,3R,4R)-2,3-dihydroxy-4-hydroxymethyl-cyclopentyl)-1,9-dihydro-purin-6-one; 6H-Purin-6-one, 2-amino-9-[2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-1,9-dihydro-, [1R-(1α,2β,3β,4α)]-; 2-Amino-9-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]-1,9-dihydro-6H-purin-6-one; D-Carbocyclic-2'-deoxyguanosine;
CAS号	111687-37-7
SMILES	O=C1NC(N)=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)C3
Inchi	No data available
InchiKey	No data available
分子式 Formula	C11H15N5O4
分子量 Molecular Weight	281.27
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度
密度 Density	No data available
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	请根据产品建议的存储条件进行存储,Please store the product under the recommended condition sin the description.

HSV-TK底物(111687-37-7,HSV-TK substrate)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags：HSV-TK底物试剂,HSV-TK底物杂质,HSV-TK底物中间体,HSV-TK底物密度,HSV-TK底物溶解度,HSV-TK底物旋光度,HSV-TK底物合成,HSV-TK底物闪点,HSV-TK底物熔点,HSV-TK底物MSDS,

产品说明	HSV-TK底物(111687-37-7,HSV-TK substrate)是HSV-TK的底物,并在表达HSV-TK和旁观的细胞中诱导多对数细胞毒性.
Introduction	HSV-TK底物(111687-37-7,HSV-TK substrate)is a substrate for HSVK, and induces multiog cytotoxicity in HSVKxpressing and bystander cells. HSVK substrate shows antitumor activity.
Application1	HSV-TK底物显示抗肿瘤活性。
Application2
Application3

HSV-TK底物(111687-37-7,HSV-TK substrate)药理学：

HSV-TK底物(111687-37-7,HSV-TK substrate)是HSV-TK的底物,并在表达HSV-TK和旁观的细胞中诱导多对数细胞毒性.HSV-TK底物显示抗肿瘤活性。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Shewach DS, et al. Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells. Hum Gene Ther. 2002 Mar 1;13(4):543-51.

HSV-TK底物(111687-37-7,HSV-TK substrate)参考文献：

1、Multi-log cytotoxicity of carbocyclic 2'-deoxyguanosine in HSV-TK-expressing human tumor cells
Donna S Shewach 1, Patrick J Murphy, Blaine W Robinson, Jennifer Vuletich, Paul D Boucher, Anna L Blobaum, Laura Zerbe, John A Secrist 3rd, William B Parker

Abstract Ganciclovir (GCV) is widely used as a prodrug for selective activation in tumor cells expressing herpes simplex virus thymidine kinase (HSV-TK) because of its ability to induce multi-log cytotoxicity to HSV-TK-expressing as well as nonexpressing bystander cells. We now report that another substrate for HSV-TK, D-carbocyclic 2'-deoxyguanosine (CdG), induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells at concentrations <or=3 microM. We have compared the cytotoxicity and cell cycle effects of CdG to that observed with GCV in two human tumor cell lines. The results demonstrated that cytotoxicity of CdG was similar to that of GCV in both U251 glioblastoma and SW620 colon carcinoma cells that stably expressed HSV-TK. In addition, CdG induced a potent bystander effect in both cell types in co-cultures consisting of HSV-TK-expressing and nonexpressing bystander (lacZ-expressing) cells at ratios of 50:50 or 10:90. Selectivity for HSV-TK-expressing compared to lacZ-expressing cells was similar for CdG and GCV in the U251 cells, however CdG was less selective than GCV in the SW620 cell lines. Despite their ability to induce multi-log cytotoxicity at similar concentrations, CdG and GCV exhibited differential effects on cell cycle progression. Cells incubated with 1 microM CdG for 24 hr accumulated in S-phase and G(2)/M after drug washout, and the majority of cells died prior to cell division. This contrasts with the delayed effects of 1 microM GCV that were not evident until after cell division when cells attempted S-phase for the second time. Thus, CdG is a potent cytotoxic agent that merits further investigation to determine whether it will be therapeutically effective in enzyme-prodrug therapy with HSV-TK.

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