53783-83-8|曲金刚胺|Tromantadine|MFCD00869480-范德生物科技公司

曲金刚胺

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names：
Tromantadine
CAS号：
53783-83-8
MDL Number： MFCD00869480
MF(分子式)： C16H28N2O2 MW(分子量)： 280.41
EINECS:258-770-0 Reaxys Number:
Pubchem ID:64377 Brand:BIOFOUNT

曲金刚胺(53783-83-8,Tromantadine)是Amantadine衍生物，具有抗疱疹活性，曲金刚胺可抑制单纯疱疹病毒1型（HSV-1）和HSV-2的复制。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000720-5mg	5mg	>99.0%	¥ 5062.00	¥ 5062.00		Backorder	- +	¥ 0.00
YZM000720-1mg	1mg	>99.0%	¥ 1950.00	¥ 1950.00		2-3天	- +	¥ 0.00

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中文别名	曲金刚胺(53783-83-8);D 41;曲曼他定;N-（1-金刚烷基）-2-（2-二甲基氨基乙氧基）乙酰胺;姜黄素;曲曼他定'盐酸金刚烷胺;一水合盐酸金刚烷胺，一水合物;甘露定;维鲁·梅尔兹;维鲁·梅尔兹·塞罗尔;塞鲁尔;
英文别名	Tromantadine(53783-83-8);D 41;N-(1-adamantyl)-2-(2-dimethylaminoethoxy)acetamide;tromantadin;tromantadine;tromantadine monohydrochloride;tromantadine monohydrochloride, monohydrate;tromantidine;Viru-Merz;Viru-Merz serol;Viru-Serol;
CAS号	53783-83-8
SMILES	O=C(COCCN(C)C)NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1
Inchi	InChI=1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19)
InchiKey	UXQDWARBDDDTKG-UHFFFAOYSA-N
分子式 Formula	C16H28N2O2
分子量 Molecular Weight	280.41
闪点 FP	216.6±24.0 °C
熔点 Melting point	No data available
沸点 Boiling point	434.5±28.0 °C at 760 mmHg
Polarizability极化度
密度 Density	1.09±0.1克/立方厘米
蒸汽压 Vapor Pressure	0.0±1.0 mmHg at 25°C
溶解度Solubility
性状	Solid
储藏条件 Storage conditions	存放在阴凉干燥处Pure form -20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

曲金刚胺(53783-83-8,Tromantadine)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags：曲金刚胺试剂,曲金刚胺杂质,曲金刚胺中间体,曲金刚胺密度,曲金刚胺熔点,曲金刚胺闪点,曲金刚胺合成,曲金刚胺结构式,曲金刚胺购买,曲金刚胺MSDS,

产品说明	曲金刚胺(53783-83-8,Tromantadine)是一种有效的单纯疱疹病毒 (HSV) 的抑制剂
Introduction	曲金刚胺(53783-83-8,Tromantadine) is a herpes simplex virus (HSV) inhibitor.
Application1	曲金刚胺是具有抗疱疹活性的金刚烷胺衍生物，可抑制单纯疱疹病毒1型（HSV-1）和HSV-2复制
Application2	Tromantadine是一种局部抗疱疹药物，对单纯疱疹病毒1型（HSV-1）复制具有两个独立的作用：早期，在病毒结合或穿透过程中，晚期，在DNA合成开始后。
Application3

曲金刚胺(53783-83-8,Tromantadine)药理学：

1、曲金刚胺是一种环状胺，具有抗单纯疱疹病毒的活性。Tromantadine抑制病毒体吸收到细胞表面，以及病毒的渗透和脱膜。 Tromantadine在捷克共和国的市场名为Viru-Merz。曲金刚胺是一种抗病毒药，用于治疗带状疱疹和单纯性疱疹。

2、曲金刚胺是抗病毒剂，曲金刚胺用于预防或治疗病毒性疾病的药物。曲金刚胺可能发挥作用的方式包括通过抑制病毒DNA聚合酶来防止病毒复制。曲金刚胺与特定的细胞表面受体结合并抑制病毒渗透或脱壳；抑制病毒蛋白质合成；或阻止病毒组装的后期。

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Rosenthal KS, et al. Tromantadine: inhibitor of early and late events in herpes simplex virus replication. Antimicrob Agents Chemother. 1982 Dec;22(6):1031-6.

Cheetham JJ, et al. Comparison of the interaction of the anti-viral chemotherapeutic agents amantadine and tromantadine with model phospholipid membranes. Biosci Rep. 1987 Mar;7(3):225-30.

Comparison of the interaction of the anti-viral chemotherapeutic agents amantadine and tromantadine with model phospholipid membranes Bioscience Reports 1987

Tromantadine Reactions Weekly 2018

Aciclovir and tromantadine have comparable efficacy InPharma 1989

曲金刚胺(53783-83-8,Tromantadine)参考文献：

1.Separation methods for tricyclic antiviral drugs.
Suckow RF1. J Chromatogr B Biomed Sci Appl. 2001 Nov 25;764(1-2):313-25.

A review of the published analytical methodology for the tricyclic antiviral (TAV) drugs is presented. While amantadine and rimantadine are the only two approved drugs for the prophylaxis and treatment of the influenza A virus, amantadine has also been approved for the treatment of Parkinson's disease. In addition, a few structurally related compounds are finding important clinical applications in other central nervous system-related disorders. To effectively evaluate the pharmacokinetics, biotransformations, stability, and other critical parameters that are necessary for pre-clinical and clinical studies, analytical methodology that conforms to the rigors of regulatory requirements must be developed and made available. This review discusses the analytical methods used in the determination of amantadine, rimantadine, tromantadine and memantine and the pre-clinical and clinical application of these techniques.

2.Topical tromantadine in the treatment of genital herpes. A double-blind placebo controlled study.
Petersen CS1, Weismann K, Avnstorp C, Rasmussen LP, Fogh H, Tikjøb G. Dan Med Bull. 1993 Sep;40(4):506-7.

A randomised double-blind placebo controlled trial was performed to assess the efficacy and safety of tromantadine ointment 1% in male patients with genital herpes. 45 patients with penile genital herpes of less than three days duration were randomised to local treatment with tromantadine ointment 1% or placebo (ointment base alone) five times daily up to 12 days. No difference in time of healing could be detected between the two groups (p = 1.0). Both the objective signs (vesicles, pustules, ulceration, and glandular swelling) and the subjective symptoms (itching, burning, pain and dysuria) all diminished simultaneously in the two groups.

3.Allergic contact dermatitis from tromantadine.
Jáuregui I1, Urrutia I, Gamboa PM, Antépara I. J Investig Allergol Clin Immunol. 1997 Jul-Aug;7(4):260-1.

Tromantadine is a topical antiviral agent derived from amantadine. In previous reports, 5% of treated patients developed contact allergy. We report the case of a 28-year-old woman who had a sudden worsening of a lip herpes after treatment with a tromantadine ointment, with strong positive patch testing to this substance. The purpose of this paper is to call attention to the fact that tromantadine is still widely used in several European countries as a second-line therapy for lip herpes, and therefore, new cases of sensitization to tromantadine are likely to occur.

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