442666-98-0|Anguizole|Anguizole|MFCD03308216-范德生物科技公司

Anguizole

NMR下载 COA and HPLC MSDS下载
names：
Anguizole
CAS号：
442666-98-0
MDL Number： MFCD03308216
MF(分子式)： C17H11ClF2N4O2S MW(分子量)： 408.81
EINECS: Reaxys Number:
Pubchem ID:1046082 Brand:BIOFOUNT

Anguizole(cas:442666-98-0)是HCV复制的小分子抑制剂，能改变NS4B的亚细胞分布。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000582-10mg	10mg	99.33%	¥ 1694.00	¥ 1694.00		2-3天	- +	¥ 0.00
YZM000582-5mg	5mg	99.33%	¥ 978.90	¥ 978.90		2-3天	- +	¥ 0.00

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中文别名	Anguizole(cas:442666-98-0)
英文别名	Anguizole(cas:442666-98-0),7-[Chlor(difluor)methyl]-5-(2-furyl)-N-(2-thienylmethyl)pyrazolo[1,5-a]pyrimidin-2-carboxamid
CAS号	442666-98-0
SMILES	FC(Cl)(C1=CC(C2=CC=CO2)=NC3=CC(C(NCC4=CC=CS4)=O)=NN31)F
Inchi	InChI=1S/C17H11ClF2N4O2S/c18-17(19,20)14-7-11(13-4-1-5-26-13)22-15-8-12(23-24(14)15)16(25)21-9-10-3-2-6-27-10/h1-8H,9H2,(H,21,25)
InchiKey	GBNREAYNZPJROB-UHFFFAOYSA-N
分子式 Formula	C17H11ClF2N4O2S
分子量 Molecular Weight	408.81
闪点 FP	No data available
熔点 Melting point	No data available
沸点 Boiling point	No data available
Polarizability极化度	39.1±0.5 10-24cm3
密度 Density	1.6±0.1 g/cm3
蒸汽压 Vapor Pressure	No data available
溶解度Solubility	生物体外In Vitro:DMSO溶解度50 mg/mL(122.31 mM;Need ultrasonic)H2O< 0.1 mg/mL(insoluble)
性状	固体粉末,Power
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

Anguizole(CAS:442666-98-0)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:Anguizole蒸汽压,Anguizole合成,Anguizole标准,Anguizole应用,Anguizole合成,Anguizole沸点,Anguizole闪点,Anguizole用途,Anguizole溶解度,Anguizole价格,Anguizole作用,Anguizole结构式,Anguizole用处

产品说明	Anguizole(442666-98-0)是HCV复制的小分子抑制剂，能改变NS4B的亚细胞分布。
Introduction	Anguizole(442666-98-0) is a small molecule inhibitor of HCV replication and alters NS4B's subcellular distribution.IC50 Value:
Application1
Application2
Application3

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

2014-03-13 Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives Journal of medicinal chemistry

2013-12-01 A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A Virus genes

2010-07-01 A small molecule inhibits HCV replication and alters NS4B's subcellular distribution Antiviral research

A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B’s dimerization/multimerization as well as its interaction with NS5A Virus Genes 2013

A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A PMID 23868571; Virus genes 2013 Dec; 47(3)

A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B's dimerization/multimerization as well as its interaction with NS5A/PMID 23868571; Virus genes 2013 Dec; 47(3):395-407/Name matches: chronic hepatitis c anguizole
Abstract：Chronic hepatitis C virus (HCV) infection is responsible for severe liver diseases including liver cirrhosis and hepatocellular carcinoma. An HCV non-structural protein 4B (NS4B) plays an essential role in viral RNA genome replication by building multi-vesicular structures around endoplasmic reticulum membranes. Especially, the second amphipathic helix of NS4B (NS4B-AH2) was shown to be essential for this process. By screening compounds against a membrane-aggregating activity of NS4B-AH2, several anti-HCV replication small molecules targeting NS4B-AH2 were discovered. However, little is known about detailed molecular mechanism of action for these NS4B-AH2 inhibitors. In this report, we provide evidences that NS4B-AH2 is required for NS4B's dimerization/multimerization, its proper subcellular localization, as well as its interaction with NS5A. More importantly, one of NS4B-AH2 inhibitors called "anguizole" was found to be able to disrupt all of these NS4B-AH2-mediated biological functions of NS4B. This newly elucidated mechanism of action will enable us not only to better understand a central role of NS4B-AH2 in HCV life cycle but also to develop a more safe and effective new class of NS4B-AH2 inhibitors of HCV replication in the future.

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