163252-36-6|克拉夫定|Clevudine|MFCD00935785-范德生物科技公司

克拉夫定

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names：
Clevudine
CAS号：
163252-36-6
MDL Number： MFCD00935785
MF(分子式)： C10H13FN2O5 MW(分子量)： 260.22
EINECS: Reaxys Number:
Pubchem ID:73115 Brand:BIOFOUNT

克拉夫定(Clevudine,163252-36-6)是一种合成的嘧啶类似物，对乙型肝炎病毒（HBV）具有活性。在细胞内，克列夫定被磷酸化为其活性代谢产物，克拉夫定单磷酸盐和三磷酸盐。三磷酸代谢物与胸苷竞争并入病毒DNA中，从而导致DNA链终止并抑制HBV DNA聚合酶（逆转录酶）的功能。克拉夫定具有长的半衰期，并且显示出共价闭合的环状DNA（cccDNA）的显着减少.

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM000536-50mg	50mg	99.95%	¥ 6874.00	¥ 6874.00		2-3天	- +	¥ 0.00
YZM000536-10mg	10mg	99.95%	¥ 2184.00	¥ 2184.00		2-3天	- +	¥ 0.00

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中文别名	克拉夫定(cas:163252-36-6),1-(2'-脱氧-2'-氟-L-阿拉伯呋喃糖基)-5-甲基尿嘧啶
英文别名	Clevudine(cas:163252-36-6),Levovir,L-FMAU,Clevudine (Levovir)
CAS号	163252-36-6
SMILES	O=C(C(C)=CN1[C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)NC1=O
Inchi	InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1
InchiKey	GBBJCSTXCAQSSJ-XQXXSGGOSA-N
分子式 Formula	C10H13FN2O5
分子量 Molecular Weight	260.22
闪点 FP	No data available
熔点 Melting point	184-185°
沸点 Boiling point	No data available
Polarizability极化度	22.4±0.5 10-24cm3
密度 Density	1.6±0.1 g/cm3
蒸汽压 Vapor Pressure	No data available
溶解度Solubility	生物体外In Vitro:DMSO溶解度≥ 50 mg/mL(192.15 mM)*"≥" means soluble可溶, but saturation unknown溶解度未知.
性状	固体粉末,Power
储藏条件 Storage conditions	-20°C 3 years年 4°C 2 years年 / In solvent溶液中:-80°C 6 months月 -20°C 1 month月

Clevudine(CAS:163252-36-6)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tag:克拉夫定蒸汽压,克拉夫定合成,克拉夫定标准,克拉夫定应用,克拉夫定合成,克拉夫定沸点,克拉夫定闪点,克拉夫定用途,克拉夫定溶解度,克拉夫定价格,克拉夫定作用,克拉夫定结构式,克拉夫定用处

产品说明	克拉夫定(Clevudine,163252-36-6)是嘧啶2'-脱氧核糖核苷。克拉夫定溶解度,克拉夫定MSDS详见主页。
Introduction	Clevudine (克拉夫定,163252-36-6)is a pyrimidine 2'-deoxyribonucleoside.
Application1	udine是一种合成的嘧啶类似物，对乙型肝炎病毒（HBV）具有活性。在细胞内，克列夫定被磷酸化为其活性代谢产物，克列夫定单磷酸盐和三磷酸盐。
Application2	克列夫定具有长的半衰期
Application3

克拉夫定(Clevudine,163252-36-6)brief：
Clevudine is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase (reverse transcriptase). Clevudine has a long half-life and shows significant reduction of covalently closed circular DNA (cccDNA)

警示图
危险性	warning
危险性警示	Not available
安全声明	H303吞入可能有害+H313皮肤接触可能有害+H2413吸入可能对身体有害
安全防护	P264处理后彻底清洗+P280戴防护手套/穿防护服/戴防护眼罩/戴防护面具+P305如果进入眼睛+P351用水小心冲洗几分钟+P338取出隐形眼镜（如果有）并且易于操作,继续冲洗+P337如果眼睛刺激持续+P2393获得医疗建议/护理
备注	实验过程中防止吸入、食入，做好安全防护

Clevudine-induced viral response, associated with continued reduction of HBsAg titer, was durable after the withdrawal of therapy Journal of Gastroenterology 2010

A comparison of clevudine and entecavir for treatment-na?ve patients with chronic hepatitis B: results after 2 years of treatment Hepatology International 2012

A comparison of 48-week treatment efficacy between clevudine and entecavir in treatment-na?ve patients with chronic hepatitis B Hepatology International 2010

Monofluorinated Heterocycles Halogenated Heterocycles 2011

2013-09-01 Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine Antimicrobial agents and chemotherapy

其他文献：
1. 2013-09-01   Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine   Antimicrobial agents and chemotherapy
2. 2012-10-01   Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU)   Nuclear medicine and biology
3. 2012-09-01   [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations   Molecular imaging
4. 2012-04-01   Simultaneous determination of 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) uracil (FAU) and 1-(2'-deoxy-2'-fluoro-β-D-arabinofuranosyl) 5-methyluracil (FMAU) in human plasma by liquid chromatography/tandem mass spectrometry   Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
5. 2012-04-01   [New drugs of treatment of patients with chronic hepatitis B]   Nihon rinsho. Japanese journal of clinical medicine

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