1334314-19-0|methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride|methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride|-范德生物科技公司

methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride

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names：
methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride
CAS号：
1334314-19-0
MDL Number：
MF(分子式)： C43H54Cl2F2N8O6Si MW(分子量)： 915.9368
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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FMK22207-100mg	100mg	>98%	¥ 0.00	¥ 0.00		Get quote	- +	¥ 0.00

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中文别名
英文别名	MK-8325
CAS号	1334314-19-0
SMILES	O=C(N1C[Si](C)(C[C@H]1C2=NC3=CC=C4C(C=CC(C5=CC=C(C=C5)C6=CN=C(N6)[C@@H]7CC(F)(CN7C([C@@H](NC(OC)=O)C(C)C)=O)F)=C4)=C3N2)C)[C@@H](NC(OC)=O)C(C)C.[H]Cl.[H]Cl
Inchi
InchiKey
分子式 Formula	C43H54Cl2F2N8O6Si
分子量 Molecular Weight	915.9368
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状
储藏条件 Storage conditions	Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

产品说明	methyl ((S)-1-((R)-5-(7-(4-(2-((S)-4,4-difluoro-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)phenyl)-1H-naphtho[1,2-d]imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride(CAS:1334314-19-0 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	MK-8325 is a ptent HCV NS5A inhibitor with excellent replicon activity across multiple genotypes. The human dose prediction using allometric scaling from rat, dog and monkey studies (corrected with PPB) based on maintaining a trough free plasma concentration of 1XEC90 showed a projected mean loading dose of 60 mg/day. In vitro and in vivo assays showed MK-8325 to be orally bioavailable with pharmacokinetics suitable for once-daily dosing in patients and good overall ADME profiles.
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