192564-13-9|Leteprinim potassium|potassium 4-(3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propanamido)benzoate|-范德生物科技公司

Leteprinim potassium

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names：
potassium 4-(3-(6-oxo-1,6-dihydro-9H-purin-9-yl)propanamido)benzoate
CAS号：
192564-13-9
MDL Number：
MF(分子式)： C15H12KN5O4 MW(分子量)： 365.3903
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Leteprinim potassium
英文别名	AIT-082; SPI-205; AIT082; SPI205; AIT 082; SPI 205
CAS号	192564-13-9
SMILES	O=C([O-])C1=CC=C(NC(CCN2C=NC3=C2N=CNC3=O)=O)C=C1.[K+]
Inchi	InChI=1S/C15H13N5O4.K/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22;/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22);/q;+1/p-1
InchiKey	MICLTPPSCUXHJT-UHFFFAOYSA-M
分子式 Formula	C15H12KN5O4
分子量 Molecular Weight	365.3903
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Leteprinim potassium(CAS:192564-13-9 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Leteprinim, also known as AIT-082 and SPI-205, is a neurotrophic agent potentially for the treatment of Alzheimer's disease, and spinal cord injury.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Morrone CD, Thomason LA, Brown ME, Aubert I, McLaurin J. Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease. PLoS One. 2016 Oct 21;11(10):e0165393. doi: 10.1371/journal.pone.0165393. PubMed PMID: 27768761; PubMed Central PMCID: PMC5074589.

[2]Jiang S, Khan MI, Middlemiss PJ, Lu Y, Werstiuk ES, Crocker CE, Ciccarelli R, Caciagli F, Rathbone MP. AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats. Int J Immunopathol Pharmacol. 2004 Sep-Dec;17(3):353-66. PubMed PMID: 15461869.

[3] Johnston TH, Brotchie JM. Drugs in development for Parkinson's disease. Curr Opin Investig Drugs. 2004 Jul;5(7):720-6. Review. PubMed PMID: 15298067.

[4] Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506. PubMed PMID: 12949633.

[5] Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2002 Dec;24(10):703-29. PubMed PMID: 12616965.

6: Yan R, Taylor EM. Neotrofin is transported out of brain by a saturable mechanism: possible involvement of multidrug resistance and monocarboxylic acid transporters. Drug Metab Dispos. 2002 May;30(5):513-8. PubMed PMID: 11950780.7: Rathbone MP, Middlemiss PJ, Crocker CE, Glasky MS, Juurlink BH, Ramirez JJ, Ciccarelli R, Di Iorio P, Caciagli F. AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury. Expert Opin Investig Drugs. 1999 Aug;8(8):1255-62. PubMed PMID: 15992149.

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