58880-43-6|Cridanimod sodium|Sodium 2-(9-oxoacridin-10(9H)-yl)acetate|-范德生物科技公司

Cridanimod sodium

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names：
Sodium 2-(9-oxoacridin-10(9H)-yl)acetate
CAS号：
58880-43-6
MDL Number：
MF(分子式)： C15H10NNaO3 MW(分子量)： 275.23
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Cridanimod sodium
英文别名	Cridanimod sodium; Cridanimod Na; Sodium Cridanimod; XBIO101; XBIO-101; XBIO 101; Cycloferon; Cyclopheron;
CAS号	58880-43-6
SMILES	O=C([O-])CN(C1=C2C=CC=C1)C3=CC=CC=C3C2=O.[Na+]
Inchi	InChI=1S/C15H11NO3.Na/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16;/h1-8H,9H2,(H,17,18);/q;+1/p-1
InchiKey	FQMLTEAEJZVTAJ-UHFFFAOYSA-M
分子式 Formula	C15H10NNaO3
分子量 Molecular Weight	275.23
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	A crystalline solid
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cridanimod sodium(CAS:58880-43-6 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cridanimod, also known as XBIO-101, is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells.
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警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Cavlar, T., Deimling, T., Ablasser, A., et al. Species-specific detection of the antiviral small-molecule compound CMA by STING. EMBO J. 32(10), 1440-1450 (2013).2. Taylor, J.L., Schoenherr, C.K., and Grossberg, S.E. High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters. Antimicrob. Agents Chemother. 18(1), 20-26 (1980).3. Kramer, M.J., Cleeland, R., and Grunberg, E. Antiviral activity of 10-carboxymethyl-9-acridanone. Antimicrob. Agents Chemother. 9(2), 233-238 (1976).4. Surkov, K.G., Tsyrlina, E.V., Konstantinova, M.M., et al. Neovir, an interferon inductor, modifies expression of steroid hormone receptors in hormone-dependent tissues and restores sensitivity to tamoxifen in patients with inoperable breast cancer. Vopr. Onkol. 42(6), 28-32 (1996).