93287-54-8|Cgp 29287|Cgp 29287|-范德生物科技公司

Cgp 29287

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names：
Cgp 29287
CAS号：
93287-54-8
MDL Number：
MF(分子式)： C72H110N20O15 MW(分子量)： 1495.79
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	methyl N2-((3S,4S)-4-((S)-2-((S)-2-((S)-1-(((benzyloxy)carbonyl)-L-arginyl-L-arginyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-3-(1H-imidazol-4-yl)propanamido)-3-hydroxy-6-methylheptanoyl)-L-isoleucyl-L-histidyl-N6-(tert-butoxycarbonyl)-L-lysinate
英文别名	Cgp 29287; Cgp-29287; Cgp29287; Cgp-29,287; Cgp 29,287; Cgp29,287;
CAS号	93287-54-8
SMILES	O=C(OC)[C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC1=CNC=N1)NC([C@H]([C@@H](C)CC)NC(C[C@H](O)[C@@H](NC([C@H](CC2=CNC=N2)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(OCC5=CC=CC=C5)=O)=O)=O)CCC4)=O)=O)=O)CC(C)C)=O)=O)=O
Inchi	InChI=1S/C72H110N20O15/c1-9-44(4)59(65(100)89-55(36-48-39-78-42-83-48)62(97)85-51(67(102)105-8)25-16-17-29-81-70(103)107-72(5,6)7)91-58(94)37-57(93)52(33-43(2)3)86-63(98)54(35-47-38-77-41-82-47)87-61(96)53(34-45-21-12-10-13-22-45)88-64(99)56-28-20-32-92(56)66(101)50(27-19-31-80-69(75)76)84-60(95)49(26-18-30-79-68(73)74)90-71(104)106-40-46-23-14-11-15-24-46/h10-15,21-24,38-39,41-44,49-57,59,93H,9,16-20,25-37,40H2,1-8H3,(H,77,82)(H,78,83)(H,81,103)(H,84,95)(H,85,97)(H,86,98)(H,87,96)(H,88,99)(H,89,100)(H,90,104)(H,91,94)(H4,73,74,79)(H4,75,76,80)/t44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-/m0/s1
InchiKey	DLAHCJHYEAZDLE-VRYQDWSQSA-N
分子式 Formula	C72H110N20O15
分子量 Molecular Weight	1495.79
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Cgp 29287(CAS:93287-54-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Cgp 29287 is a primate-specific renin inhibitor with prolonged duration of action.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Samani NJ, Cumin F, Kelly M, Wood JM. Expression of components of the RAS during prolonged blockade at different levels in primates. Am J Physiol. 1994 Oct;267(4 Pt 1):E612-9. PubMed PMID: 7943312.

[2]Humke U, Levens N, Wood J, Hofbauer K. Responses to renin inhibition in conscious primates. Am J Physiol. 1991 Jul;261(1 Pt 2):F179-86. PubMed PMID: 1907105.

[3] Nussberger J, Brunner DB, Waeber B, Brunner HR. In vitro renin inhibition to prevent generation of angiotensins during determination of angiotensin I and II. Life Sci. 1988;42(17):1683-8. PubMed PMID: 2835564.

[4] de Gasparo MM, Wood JM, Heusser CH. Mechanism of inhibition of human renin by monoclonal antibodies. Hypertension. 1988 Mar;11(3):209-16. PubMed PMID: 3280480.

[5] Wood JM, Jobber RA, Baum HP, Hofbauer KG. Comparison of chronic inhibition of renin and converting enzyme in the marmoset. Clin Exp Hypertens A. 1987;9(2-3):337-43. PubMed PMID: 3038392.

6: Wood JM, Baum HP, Carleton J, Dzau VJ. Inhibition of renin-like activity in marmoset tissues by the renin inhibitor CGP 29 287. J Hypertens Suppl. 1987 Jul;5(2):S67-9. PubMed PMID: 3116182.7: Wood JM, Gulati N, Forgiarini P, Fuhrer W, Hofbauer KG. Effects of a specific and long-acting renin inhibitor in the marmoset. Hypertension. 1985 Sep-Oct;7(5):797-803. PubMed PMID: 3928488.8: Wood JM, Baum HP, Forgiarini P, Gulati N, Jobber RA, Neisius D, Hofbauer KG. Haemodynamic effects of acute and chronic renin inhibition in marmosets. J Hypertens Suppl. 1989 Apr;7(2):S37-42. PubMed PMID: 2547039.9: Wood JM, Baum HP, Jobber RA, Neisius D. Sustained reduction in blood pressure during chronic administration of a renin inhibitor to normotensive marmosets. J Cardiovasc Pharmacol. 1987;10 Suppl 7:S96-8. PubMed PMID: 2485073.10: Wood JM, Jobber RA, Baum HP, de Gasparo M, Nussberger J. Biochemical effects of prolonged renin inhibition in marmosets. J Hypertens. 1989 Aug;7(8):615-8. PubMed PMID: 2681408.1

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