34461-73-9|Bumadizone Calcium|calcium 2-(1,2-diphenylhydrazine-1-carbonyl)hexanoate|-范德生物科技公司

Bumadizone Calcium

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names：
calcium 2-(1,2-diphenylhydrazine-1-carbonyl)hexanoate
CAS号：
34461-73-9
MDL Number：
MF(分子式)： C38H42CaN4O6 MW(分子量)： 690.854
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Bumadizone Calcium
英文别名	Bumadizone Calcium; B-64114; B-64114; B-64114; Eumotol;
CAS号	34461-73-9
SMILES	O=C([O-])C(CCCC)C(N(C1=CC=CC=C1)NC2=CC=CC=C2)=O.O=C([O-])C(CCCC)C(N(C3=CC=CC=C3)NC4=CC=CC=C4)=O.[Ca+2]
Inchi	InChI=1S/2C19H22N2O3.Ca/c21-2-3-14-17(19(23)24)18(22)21(16-12-8-5-9-13-16)20-15-10-6-4-7-11-15;/h24-13,17,20H,2-3,14H2,1H3,(H,23,24);/q;;+2/p-2
InchiKey	RKINNRASCJRSHD-UHFFFAOYSA-L
分子式 Formula	C38H42CaN4O6
分子量 Molecular Weight	690.854
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Bumadizone Calcium(CAS:34461-73-9 ):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Bumadizone Calcium, also known as Eumotol and B-64114, is a non-steroidal anti-inflammatory drug used to treat pain and arthritis.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Goto W, Ichikawa M, Tanaka E, Hara H, Araie M. Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures. Brain Res. 2004 Apr 2;1003(1-2):130-7. PubMed PMID: 15019572.

[2]Kobayashi H, Kobayashi K, Okinami S. Efficacy of bunazosin hydrochloride 0.01% as adjunctive therapy of latanoprost or timolol. J Glaucoma. 2004 Feb;13(1):73-80. PubMed PMID: 14704548.

[3] Yoshikawa K, Katsushima H, Kimura T, Yamagishi K, Yamabayashi S. Addition of or switch to topical bunazosin hydrochloride in elderly patients with normal-tension glaucoma: A one-year follow-up study. Jpn J Ophthalmol. 2006 Sep-Oct;50(5):443-8. PubMed PMID: 17013697.

[4] Okada Y, Ichikawa M, Ishii K, Hara H. Effects of topically instilled bunazosin hydrochloride and other ocular hypotensive drugs on endothelin-1-induced constriction in rabbit retinal arteries. Jpn J Ophthalmol. 2004 Sep-Oct;48(5):465-9. PubMed PMID: 15486769.

[5] Hara H, Ichikawa M, Oku H, Shimazawa M, Araie M. Bunazosin, a selective alpha1-adrenoceptor antagonist, as an anti-glaucoma drug: effects on ocular circulation and retinal neuronal damage. Cardiovasc Drug Rev. 2005 Spring;23(1):43-56. Review. PubMed PMID: 15867947.

6: Mochizuki Y, Oishi M, Takasu T. Effects of bunazosin hydrochloride sustained-release formulation on cerebral circulation. Int Angiol. 2000 Mar;19(1):35-8. PubMed PMID: 10853683.7: Akaishi T, Takagi Y, Matsugi T, Ishida N, Hara H, Kashiwagi K. Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities. J Glaucoma. 2004 Aug;13(4):312-8. PubMed PMID: 15226660.8: Goto W, Oku H, Okuno T, Sugiyama T, Ikeda T. Amelioration by topical bunazosin hydrochloride of the impairment in ocular blood flow caused by nitric oxide synthase inhibition in rabbits. J Ocul Pharmacol Ther. 2003 Feb;19(1):63-73. PubMed PMID: 12648305.9: Hu WY, Fukuda N, Soma M, Izumi Y, Kanmatsuse K. Bunazosin hydrochloride inhibits exaggerated growth of vascular smooth muscle cells from spontaneously hypertensive rats by suppressing the response to growth factors. J Cardiovasc Pharmacol. 1998 Dec;32(6):975-82. PubMed PMID: 9869504.10: Yang SC, Tsai WI, Liau CS, Wang TD. Effect of 8-Week Combination Therapy with an Extended-Release α1-Blocker (Bunazosin or Doxazosin) in Inadequate Responders to an Angiotensin II Antagonist (Valsartan) in Patients with Stage 1 or 2 Essential Hypertension. Acta Cardiol Sin. 2013 Jan;29(1):11-8. PubMed PMID: 27122680; PubMed Central PMCID: PMC4804956.1

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