83133-14-6|Yuanhuanin|3'-Hydroxygenkwanin 5-O-beta-glucoside|-范德生物科技公司

Yuanhuanin

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names：
3'-Hydroxygenkwanin 5-O-beta-glucoside
CAS号：
83133-14-6
MDL Number：
MF(分子式)： C22H22O11 MW(分子量)： 462.407
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	3'-Hydroxygenkwanin 5-O-beta-glucoside
英文别名	Yuanhuanin;
CAS号	83133-14-6
SMILES	O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=C1C(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(OC)=C3
Inchi	InChI=1S/C22H22O11/c1-30-10-5-15-18(13(26)7-14(31-15)9-2-3-11(24)12(25)4-9)16(6-10)32-22-21(29)20(28)19(27)17(8-23)33-22/h2-7,17,19-25,27-29H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1
InchiKey	ZXVSQQSRCKKYLS-MIUGBVLSSA-N
分子式 Formula	C22H22O11
分子量 Molecular Weight	462.407
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Yuanhuanin(CAS:83133-14-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Yuanhuanin is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Han BS, Minh NV, Choi HY, Byun JS, Kim WG. Daphnane and Phorbol Diterpenes, Anti-neuroinflammatory Compounds with Nurr1 Activation from the Roots and Stems of Daphne genkwa. Biol Pharm Bull. 2017;40(12):2205-221[1]doi: 10.1248/bpb.b17-0064[1]PubMed PMID: 29199243.

[2]Li M, Liu X, Cai H, Shen Z, Xu L, Li W, Wu L, Duan J, Chen Z. Validation and Application of an Ultra High-Performance Liquid Chromatography Tandem Mass Spectrometry Method for Yuanhuacine Determination in Rat Plasma after Pulmonary Administration: Pharmacokinetic Evaluation of a New Drug Delivery System. Molecules. 2016 Dec 16;21(12). pii: E1733. doi: 10.3390/molecules21121733. PubMed PMID: 27999290.

[3] Han BS, Kim KS, Kim YJ, Jung HY, Kang YM, Lee KS, Sohn MJ, Kim CH, Kim KS, Kim WG. Daphnane Diterpenes from Daphne genkwa Activate Nurr1 and Have a Neuroprotective Effect in an Animal Model of Parkinson's Disease. J Nat Prod. 2016 Jun 24;79(6):1604-9. doi: 10.1021/acs.jnatprod.6b00110. Epub 2016 May 26. PubMed PMID: 27228307; PubMed Central PMCID: PMC5635821.

[4] Li L, Yin FZ, Lu TL, Guan HY, Cai BC. [Fingerprint of Vinegar Processed Genkwa Flos Based on Improving Euclidean Distance]. Zhong Yao Cai. 2015 Jun;38(6):1168-71. Chinese. PubMed PMID: 26762055.

[5] Kang JI, Hong JY, Lee HJ, Bae SY, Jung C, Park HJ, Lee SK. Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells. PLoS One. 2015 Dec 11;10(12):e0144368. doi: 10.1371/journal.pone.0144368. eCollection 2015. PubMed PMID: 26656173; PubMed Central PMCID: PMC4676678.

6: Zhang R, Wang Y, Li J, Jin H, Song S, Huang C. The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade. J Biol Chem. 2014 Mar 7;289(10):6394-403. doi: 10.1074/jbc.M113.513960. Epub 2014 Jan 22. PubMed PMID: 24451377; PubMed Central PMCID: PMC3945306.7: Chen YY, Qian DW, Shang EX, Qian YF, Liu P, Su SL, Guo JM, Tang YP, Duan JA. [The incompatibility mechanism based on the interaction of multiple-components for Flos Genkwa and Radix et Rhizoma Glycyrrhizae]. Yao Xue Xue Bao. 2012 Aug;47(8):1043-8. Chinese. PubMed PMID: 23162902.8: Hong JY, Nam JW, Seo EK, Lee SK. Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa. Chem Pharm Bull (Tokyo). 2010 Feb;58(2):234-7. PubMed PMID: 20118586.9: Zhang S, Gao X, Shen K, Yang P, Ju X. Evaluation of poly(D,L-lactide-co-glycolide) microspheres for the lung-targeting of yuanhuacine, a novel DNA topoisomerase I inhibitor. J Drug Target. 2009 May;17(4):286-93. doi: 10.1080/10611860902737912. PubMed PMID: 19558356.10: Zhang SX, Yang PW, Zhang DC, Dong WQ, Zhang FH, Sun YM. Pharmacokinetics, tissue distribution, and metabolism of novel DNA topoisomerase I inhibitor yuanhuacine in rabbit. Xenobiotica. 2009 Mar;39(3):273-81. doi: 10.1080/00498250802715987. PubMed PMID: 19280526.1

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