90596-75-1|YT 146|Adenosine, 2-(1-octynyl)-|-范德生物科技公司

YT 146

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names：
Adenosine, 2-(1-octynyl)-
CAS号：
90596-75-1
MDL Number：
MF(分子式)： C18H25N5O4 MW(分子量)： 375.429
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Adenosine, 2-(1-octynyl)-
英文别名	YT 146; YT-146; YT146.
CAS号	90596-75-1
SMILES	OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=C(C#CCCCCCC)N=C32)N)O1)O)O
Inchi	InChI=1S/C18H25N5O4/c1-2-3-4-5-6-7-8-12-21-16(19)13-17(22-12)23(10-20-13)18-15(26)14(25)11(9-24)27-18/h10-11,14-15,18,24-26H,2-6,9H2,1H3,(H2,19,21,22)/t11-,14-,15-,18-/m1/s1
InchiKey	NVGGIHKSKVAPEY-XKLVTHTNSA-N
分子式 Formula	C18H25N5O4
分子量 Molecular Weight	375.429
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	YT 146(CAS:90596-75-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	YT 146 is a biochemical.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Sasamori J, Abe Y, Marunouchi T, Manome Y, Uchibori T, Tanonaka K. Effects of 2-Octynyladenosine (YT-146) on Mitochondrial Function in Ischemic/Reperfused Rat Hearts. Biol Pharm Bull. 2015;38(12):1946-53. doi: 10.1248/bpb.b15-00629. PubMed PMID: 26632185.

[2]Sasamori J, Aihara K, Uchibori T, Takahashi A, Takeo S, Tanonaka K. Cardioprotective effects of 2-octynyladenosine (YT-146) in ischemic/reperfused rat hearts. J Cardiovasc Pharmacol. 2011 Feb;57(2):166-73. doi: 10.1097/FJC.0b013e318201c264. PubMed PMID: 21052018.

[3] Sasamori J, Aihara K, Yoneyama F, Sato I, Kogi K, Takeo S. Amelioration of ischemia/reperfusion-induced myocardial infarction by the 2-alkynyladenosine derivative 2-octynyladenosine (YT-146). J Cardiovasc Pharmacol. 2006 Apr;47(4):614-20. PubMed PMID: 16680077.

[4] Konno T, Murakami A, Uchibori T, Nagai A, Kogi K, Nakahata N. Involvement of adenosine A2a receptor in intraocular pressure decrease induced by 2-(1-octyn-1-yl)adenosine or 2-(6-cyano-1-hexyn-1-yl)adenosine. J Pharmacol Sci. 2005 Apr;97(4):501-9. Epub 2005 Apr 9. PubMed PMID: 15821340.

[5] Harada N, Okajima K, Murakami K, Usune S, Sato C, Ohshima K, Katsuragi T. Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation. J Pharmacol Exp Ther. 2000 Sep;294(3):1034-42. PubMed PMID: 10945856.

6: Harada N, Okajima K, Katsuragi T. [Adenosine reduces ischemia/reperfusion-induced liver injury by inhibiting leukocyte activation]. Nihon Yakurigaku Zasshi. 1999 Oct;114 Suppl 1:159P-167P. Japanese. PubMed PMID: 10629874.7: Yoneyama F, Aihara K, Kogi K, Satoh K, Taira N. Similarity and dissimilarity in mode and mechanism of action between YT-146, a selective adenosine receptor A2 agonist, and adenosine in isolated canine hearts. Tohoku J Exp Med. 1999 May;188(1):31-45. PubMed PMID: 10494898.8: Ono T, Matsuoka I, Ohkubo S, Kimura J, Nakanishi H. Effects of YT-146 [2-(1-octynyl) adenosine], an adenosine A2A receptor agonist, on cAMP production and noradrenaline release in PC12 cells. Jpn J Pharmacol. 1998 Nov;78(3):269-77. PubMed PMID: 9869260.9: Tanaka M, Takeda K, Takesako T, Takenaka K, Itoh H, Nakata T, Sasaki S, Nakagawa M. Altered cardiovascular responses to purinergic A2 stimulation in the nucleus tractus solitarius of spontaneously hypertensive rats. J Hypertens. 1995 Nov;13(11):1285-90. PubMed PMID: 8984126.10: Takiguchi Y, Nagano M, Ikeda Y, Nakashima M. Early administration of YT-146, an adenosine A2 receptor agonist, inhibits neointimal thickening after rat femoral artery endothelium injury. Eur J Pharmacol. 1995 Aug 4;281(2):205-7. PubMed PMID: 7589208.1

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