1436862-38-2|WCK-5153|(2S,5R)-7-oxo-2-(2-((S)-pyrrolidine-3-carbonyl)hydrazine-1-carbonyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate|-范德生物科技公司

WCK-5153

NMR下载 COA and HPLC MSDS下载
names：
(2S,5R)-7-oxo-2-(2-((S)-pyrrolidine-3-carbonyl)hydrazine-1-carbonyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
CAS号：
1436862-38-2
MDL Number：
MF(分子式)： C12H19N5O7S MW(分子量)： 377.372
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	(2S,5R)-7-oxo-2-(2-((S)-pyrrolidine-3-carbonyl)hydrazine-1-carbonyl)-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
英文别名	WCK-5153; WCK 5153; WCK5153.
CAS号	1436862-38-2
SMILES	O=C(NNC([C@H]1N(C[C@H]2CC1)C(N2OS(=O)(O)=O)=O)=O)[C@H]3CCNC3
Inchi	InChI=1S/C12H19N5O7S/c18-10(7-3-4-13-5-7)14-15-11(19)9-2-1-8-6-16(9)12(20)17(8)24-25(21,22)23/h7-9,13H,1-6H2,(H,14,18)(H,15,19)(H,21,22,23)/t7-,8+,9-/m0/s1
InchiKey	NAURQUDBIPQVFZ-YIZRAAEISA-N
分子式 Formula	C12H19N5O7S
分子量 Molecular Weight	377.372
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	WCK-5153(CAS:1436862-38-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	WCK-5153 is a Novel Inhibitor of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. WCK 5153 demonstrated specific high-affinity binding to PBP2 of A. baumannii. WCK 5153 shows a potent β-lactam enhancer effect against A. baumannii, including a multidrug-resistant OXA-23-producing ST2 international clone.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Papp-Wallace KM, Nguyen NQ, Jacobs MR, Bethel CR, Barnes MD, Kumar V,Bajaksouzian S, Rudin SD, Rather PN, Bhavsar S, Ravikumar T, Deshpande PK, PatilV, Yeole R, Bhagwat SS, Patel MV, van den Akker F, Bonomo RA. Strategicapproaches to overcome resistance against Gram negative pathogens usingβ-lactamase inhibitors and β-lactam enhancers: The activity of three noveldiazabicyclooctanes, WCK 5153, zidebactam (WCK 5107), and WCK 4234. J Med Chem.2018 Apr 7. doi: 10.1021/acs.jmedchem.8b0009[1][Epub ahead of print] PubMed PMID:29627985.

[2]Moya B, Barcelo IM, Bhagwat S, Patel M, Bou G, Papp-Wallace KM, Bonomo RA,Oliver A. Potent β-Lactam Enhancer Activity of Zidebactam and WCK 5153 againstAcinetobacter baumannii, Including Carbapenemase-Producing Clinical Isolates.Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01238-17. doi:10.1128/AAC.01238-17. Print 2017 Nov. PubMed PMID: 28848013; PubMed CentralPMCID: PMC5655067.

[3] Moya B, Barcelo IM, Bhagwat S, Patel M, Bou G, Papp-Wallace KM, Bonomo RA,Oliver A. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 ShowingPotent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, IncludingMultidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. AntimicrobAgents Chemother. 2017 May 24;61(6). pii: e02529-16. doi: 10.1128/AAC.02529-16.Print 2017 Jun. PubMed PMID: 28289035; PubMed Central PMCID: PMC5444176.

对不起，暂无产品评价！

MSDS

SDS 1.0 中文

展开

SDS 1.0 英文

展开