30413-87-7|Umbelliprenin|7-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)oxy)-2H-chromen-2-one|-范德生物科技公司

Umbelliprenin

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names：
7-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)oxy)-2H-chromen-2-one
CAS号：
30413-87-7
MDL Number：
MF(分子式)： C24H30O3 MW(分子量)： 366.5
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	7-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)oxy)-2H-chromen-2-one
英文别名	Angelin, Umbelliprenin
CAS号	30413-87-7
SMILES	c1(ccc2c(o1)cc(cc2)OC\C=C(\CC\C=C(\CC\C=C(\C)C)C)C)=O
Inchi	1S/C24H30O3/c1-18(2)7-5-8-19(3)9-6-10-20(4)15-16-26-22-13-11-21-12-14-24(25)27-23(21)17-22/h7,9,11-15,17H,5-6,8,10,16H2,1-4H3/b19-9+,20-15+
InchiKey	GNMUGVNEWCZUAA-WOWYBKFKSA-N
分子式 Formula	C24H30O3
分子量 Molecular Weight	366.5
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Umbelliprenin(CAS:30413-87-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Umbelliprenin, also known as Angelin, is a prenyloxy-coumarin which may have anti-inflammatory, anti-tumor, antioxidant, and antigenotoxic activities.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Naderi Alizadeh M, Rashidi M, Muhammadnejad A, Moeini Zanjani T, Ziai SA. Antitumor Effects of Umbelliprenin in a Mouse Model of Colorectal Cancer. Iran J Pharm Res. 2018 Summer;17(3):976-985. PubMed PMID: 30127820; PubMed Central PMCID: PMC6094438.

[2]Rashidi M, Khalilnezhad A, Amani D, Jamshidi H, Muhammadnejad A, Bazi A, Ziai SA. Umbelliprenin shows antitumor, antiangiogenesis, antimetastatic, anti-inflammatory, and immunostimulatory activities in 4T1 tumor-bearing Balb/c mice. J Cell Physiol. 2018 Nov;233(11):8908-8918. doi: 10.1002/jcp.26814. Epub 2018 May 24. PubMed PMID: 29797576.

[3] Khaghanzadeh N, Samiei A, Mojtahedi Z, Ramezani M, Hosseinzadeh M, Ghaderi A. Umbelliprenin induced both anti-inflammatory and regulatory cytokines in C57/BL6 mice. Iran J Basic Med Sci. 2017 Jul;20(7):829-834. doi: 10.22038/IJBMS.2017.9021. PubMed PMID: 28852449; PubMed Central PMCID: PMC5569593.

[4] Khaghanzadeh N, Nakamura K, Kuramitsu Y, Ghaderi A, Mojtahedi Z. Immune-associated proteins with potential in vivo anti-tumor activities are upregulated in lung cancer cells treated with umbelliprenin: A proteomic approach. Oncol Lett. 2016 Dec;12(6):5295-5302. doi: 10.3892/ol.2016.5352. Epub 2016 Nov 4. PubMed PMID: 28105238; PubMed Central PMCID: PMC5228441.

[5] Rashidi M, Ziai SA, Moini Zanjani T, Khalilnezhad A, Jamshidi H, Amani D. Umbelliprenin is Potentially Toxic Against the HT29, CT26, MCF-7, 4T1, A172, and GL26 Cell Lines, Potentially Harmful Against Bone Marrow-Derived Stem Cells, and Non-Toxic Against Peripheral Blood Mononuclear Cells. Iran Red Crescent Med J. 2016 May 14;18(7):e35167. eCollection 2016 Jul. PubMed PMID: 27703798; PubMed Central PMCID: PMC5027671.

6: Khaghanzadeh N, Samiei A, Ramezani M, Mojtahedi Z, Hosseinzadeh M, Ghaderi A. Umbelliprenin induced production of IFN-γ and TNF-α, and reduced IL-10, IL-4, Foxp3 and TGF-β in a mouse model of lung cancer. Immunopharmacol Immunotoxicol. 2014 Feb;36(1):25-32. doi: 10.3109/08923973.2013.863912. Epub 2013 Dec 11. PubMed PMID: 24325354.7: Khaghanzadeh N, Mojtahedi Z, Ramezani M, Erfani N, Ghaderi A. Umbelliprenin is cytotoxic against QU-DB large cell lung cancer cell line but anti-proliferative against A549 adenocarcinoma cells. Daru. 2012 Oct 30;20(1):69. doi: 10.1186/2008-2231-20-69. PubMed PMID: 23351548; PubMed Central PMCID: PMC3556042.8: Ziai SA, Gholami O, Iranshahi M, Zamani AH, Jeddi-Tehrani M. Umbelliprenin Induces Apoptosis in CLL Cell Lines. Iran J Pharm Res. 2012 Spring;11(2):653-9. PubMed PMID: 24250490; PubMed Central PMCID: PMC3832171.9: Iranshahi M, Sahebkar A, Takasaki M, Konoshima T, Tokuda H. Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. Eur J Cancer Prev. 2009 Sep;18(5):412-5. doi: 10.1097/CEJ.0b013e32832c389e. PubMed PMID: 19531956.10: Barthomeuf C, Lim S, Iranshahi M, Chollet P. Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis. Phytomedicine. 2008 Jan;15(1-2):103-11. Epub 2007 Aug 8. PubMed PMID: 17689942.

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