451470-55-6|TB-2-081|3-O-Formyl-20R,21-epoxyresibufogenin|-范德生物科技公司

TB-2-081

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names：
3-O-Formyl-20R,21-epoxyresibufogenin
CAS号：
451470-55-6
MDL Number：
MF(分子式)： C25H32O6 MW(分子量)： 428.53
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	3-O-Formyl-20R,21-epoxyresibufogenin
英文别名	TB-2-081; TB2081; TB 2 081; TB-2081; TB2-081; TB 2-081; TB-2 081
CAS号	451470-55-6
SMILES	O=CO[C@@H]1C[C@@H](CC[C@@H]2[C@@H]3CC[C@@]4(C)[C@]2(O5)[C@H]5C[C@H]4[C@]67C=CC(O[C@H]6O7)=O)[C@]3(C)CC1
Inchi	InChI=1S/C25H32O6/c1-22-8-5-15(28-13-26)11-14(22)3-4-17-16(22)6-9-23(2)18(12-19-25(17,23)30-19)24-10-7-20(27)29-21(24)31-24/h7,10,13-19,21H,3-6,8-9,11-12H2,1-2H3/t14-,15+,16+,17-,18-,19-,21+,22+,23-,24-,25-/m1/s1
InchiKey	CMYYMVGNLZUIOQ-AYFUEPLASA-N
分子式 Formula	C25H32O6
分子量 Molecular Weight	428.53
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	TB-2-081(CAS:451470-55-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	TB-2-081 is a antagonist of IL-6 signaling.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Remeniuk B, King T, Sukhtankar D, Nippert A, Li N, Li F, Cheng K, Rice KC, Porreca F. Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. Pain. 2018 Apr;159(4):684-698. doi: 10.1097/j.pain.0000000000001139. PubMed PMID: 29300279; PubMed Central PMCID: PMC5911943.

[2]Boos TL, Cheng K, Greiner E, Deschamps JR, Jacobson AE, Rice KC. Configurational reassignment and improved preparation of the competitive IL-6 receptor antagonist 20R,21R-epoxyresibufogenin-3-formate. J Nat Prod. 2012 Apr 27;75(4):661-8. doi: 10.1021/np2008957. Epub 2012 Feb 23. PubMed PMID: 22360661; PubMed Central PMCID: PMC3351795.

[3] Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F. Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist. Pain. 2010 Nov;151(2):257-65. doi: 10.1016/j.pain.2010.05.022. Epub 2010 Jul 4. PubMed PMID: 20599324; PubMed Central PMCID: PMC3313485.

[4] Kino T, Boos TL, Sulima A, Siegel EM, Gold PW, Rice KC, Chrousos GP. 3-O-Formyl-20R,21-epoxyresibufogenin suppresses IL-6-type cytokine actions by targeting the glycoprotein 130 subunit: potential clinical implications. J Allergy Clin Immunol. 2007 Aug;120(2):437-44. Epub 2007 Apr 23. PubMed PMID: 17451794.

[5] Hayashi M, Rho MC, Fukami A, Enomoto A, Nonaka S, Sekiguchi Y, Yanagisawa T, Yamashita A, Nogawa T, Kamano Y, Komiyama K. Biological activity of a novel nonpeptide antagonist to the interleukin-6 receptor 20S,21-epoxy-resibufogenin-3-formate. J Pharmacol Exp Ther. 2002 Oct;303(1):104-9. PubMed PMID: 12235239.

6: Li W, Shi X, Wang L, Guo T, Wei T, Cheng K, Rice KC, Kingery WS, Clark JD. Epidermal adrenergic signaling contributes to inflammation and pain sensitization in a rat model of complex regional pain syndrome. Pain. 2013 Aug;154(8):1224-36. doi: 10.1016/j.pain.2013.03.033. Epub 2013 Apr 12. PubMed PMID: 23718987; PubMed Central PMCID: PMC3713848.

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