143248-63-9|Sinitrodil|2-(4-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)ethyl nitrate|-范德生物科技公司

Sinitrodil

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names：
2-(4-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)ethyl nitrate
CAS号：
143248-63-9
MDL Number：
MF(分子式)： C10H10N2O5 MW(分子量)： 238.19
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	2-(4-oxo-2H-benzo[e][1,3]oxazin-3(4H)-yl)ethyl nitrate
英文别名	ITF-296; ITF296; ITF 296
CAS号	143248-63-9
SMILES	O=C1N(CCO[N+]([O-])=O)COC2=CC=CC=C12
Inchi	InChI=1S/C10H10N2O5/c13-10-8-3-1-2-4-9(8)16-7-11(10)5-6-17-12(14)15/h1-4H,5-7H2
InchiKey	POVFCWQCRHXYAB-UHFFFAOYSA-N
分子式 Formula	C10H10N2O5
分子量 Molecular Weight	238.19
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sinitrodil(CAS:143248-63-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sinitrodil is a guanylate cyclase stimulant potentially for the treatment of myocardial ischaemia and angina
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Minghetti P, Casiraghi A, Montanari L, Monzani MV. In vitro skin permeation of Sinitrodil, a member of a new class of nitrovasodilator drugs. Eur J Pharm Sci. 1999 Feb;7(3):231-6. PubMed PMID: 9845810.

[2]Monzani MV, Coltro G, Sala A, Sardina M. Pharmacokinetics of ITF 296 (Sinitrodil) a novel organic nitrate, in healthy volunteers. Eur J Pharm Sci. 1999 Feb;7(3):179-84. PubMed PMID: 9845803.

[3] Van Bortel LM, Spek JJ, Balkestein EJ, Sardina M, Struijker Boudier HA. Is it possible to develop drugs that act more selectively on large arteries? J Hypertens. 1999 May;17(5):701-5. PubMed PMID: 10403615.

[4] Khattar RS, Senior R, Sardina M, Boyce M, Lahiri A. Safety, tolerability, and antiischaemic efficacy of ITF-296, a nitric oxide donor, in patients with chronic stable angina. J Cardiovasc Pharmacol. 1998 Aug;32(2):295-9. PubMed PMID: 9700993.

[5] Giachetti C, Bertolino M, Canali S, Lombardini E, Monzani MV, Sala A, Zanolo G. Pharmacokinetic study in rats after single intravenous and oral administrations of [14C]-ITF-296. Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):230-8. PubMed PMID: 9725487.

6: Giachetti C, Bertolino M, Canali S, Lombardini E, Monzani MV, Sala A, Zanolo G. Pharmacokinetic study in dogs and monkeys after single intravenous and oral administrations of [14C]-ITF-296. Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):239-50. PubMed PMID: 9725488.7: Monzani MV, Coltro G, Jiritano L, Sala A. Simultaneous determination of ITF 296 and two metabolites in plasma by a validated HPLC method. Boll Chim Farm. 1997 Apr;136(4):382-8. PubMed PMID: 9281893.8: Duncker DJ, Mizrahi J, Bache RJ. Nitrovasodilators ITF 296 and isosorbide dinitrate exert antiischemic activity by dilating coronary penetrating arteries. J Cardiovasc Pharmacol. 1995 May;25(5):823-32. PubMed PMID: 7630161.9: Sardina M, Love R, Mizrahi J, Monzani V, Bianchini C. Safety and pharmacologic activity of a new nitrate ester, ITF 296, after intravenous administration in healthy volunteers. J Cardiovasc Pharmacol. 1995;26 Suppl

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