951441-04-6|Sephin1|(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide|-范德生物科技公司

Sephin1

NMR下载 COA and HPLC MSDS下载
names：
(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide
CAS号：
951441-04-6
MDL Number：
MF(分子式)： C8H9ClN4 MW(分子量)： 196.638
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)

大包装询价提供各种包装，敬请垂询
收藏商品商品点评加入购物车立即购买

快速询价

收起

你想询价的产品

*产品名称：

CAS号：

产品编号：

需求描述：

请准确填写您的联系方式，以便为您提供最好的服务。

*公司名称：

*电子邮箱：

联系人：

*电话：

*验证码：

询价

中文别名	(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide
英文别名	Sephin1; Sephin-1; Sephin 1, icerguastatum; icerguastat
CAS号	951441-04-6
SMILES	ClC1=CC=CC=C1/C=N/NC(N)=N
Inchi
InchiKey
分子式 Formula	C8H9ClN4
分子量 Molecular Weight	196.638
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Sephin1(CAS:951441-04-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Sephin1 is a selective inhibitor of a holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. Sephin1 selectively bound and inhibited the stress-induced PPP1R15A, but not the related and constitutive PPP1R15B, to prolong the benefit of an adaptive phospho-signaling pathway, protecting cells from otherwise lethal protein misfolding stress. In vivo, Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis. Sephin1may have potential to safely prevent two protein misfolding diseases.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Das I, Krzyzosiak A, Schneider K, Wrabetz L, D'Antonio M, Barry N,Sigurdardottir A, Bertolotti A. Preventing proteostasis diseases by selectiveinhibition of a phosphatase regulatory subunit. Science. 2015 Apr10;348(6231):239-42. doi: 10.1126/science.aaa4484. PubMed PMID: 25859045; PubMedCentral PMCID: PMC4490275.