121135-53-3|Scriptene|[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl [(2S,5R)-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl hydrogen phosphate|-范德生物科技公司

Scriptene

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names：
[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl [(2S,5R)-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl hydrogen phosphate
CAS号：
121135-53-3
MDL Number：
MF(分子式)： C20H24N9O9P MW(分子量)： 565.4398
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl [(2S,5R)-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl hydrogen phosphate
英文别名	Scriptene
CAS号	121135-53-3
Inchi	InChI=1S/C20H24N9O9P/c1-10-5-28(20(32)25-18(10)30)15-4-12(26-27-21)13(38-15)7-36-39(33,34)35-6-11-2-3-14(37-11)29-9-24-16-17(29)22-8-23-19(16)31/h5,8-9,11-15H,2-4,6-7H2,1H3,(H,33,34)(H,22,23,31)(H,25,30,32)/t11-,12-,13+,14+,15+/m0/s1
InchiKey	XURFYCWNUGWGDL-VQJWOFKYSA-N
分子式 Formula	C20H24N9O9P
分子量 Molecular Weight	565.4398
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Scriptene(CAS:121135-53-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Scriptene is an antiviral heterodimer composed of one molecule of 3'-azido-3'-deoxythymidine (AZT) and one molecule of 2',3'-dideoxyinosine (ddI) linked through their 5' positions by a phosphate bond
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Walker DM, Kajon AE, Torres SM, Carter MM, McCash CL, Swenberg JA, Upton PB, Hardy AW, Olivero OA, Shearer GM, Poirier MC, Walker VE. WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication. Environ Mol Mutagen. 2009 Jul;50(6):460-72. doi: 10.1002/em.20482. PubMed PMID: 19334055; PubMed Central PMCID: PMC3197270.

[2]Pan-Zhou XR, Cretton-Scott E, Zhou XJ, Xie MY, Rahmani R, Schinazi RF, Duchin K, Sommadossi JP. Comparative metabolism of the antiviral dimer 3'-azido-3'-deoxythymidine-P-2',3'-dideoxyinosine and the monomers zidovudine and didanosine by rat, monkey, and human hepatocytes. Antimicrob Agents Chemother. 1997 Nov;41(11):2502-10. PubMed PMID: 9371357; PubMed Central PMCID: PMC164152.

[3] Zhou XJ, Squires K, Pan-Zhou XR, Bernhard S, Agrofoglio L, Kirk M, Duchin KL, Sommadossi JP. Phase I dose-escalation pharmacokinetics of AZT-P-ddI (IVX-E-59) in patients with human immunodeficiency virus. J Clin Pharmacol. 1997 Mar;37(3):201-13. PubMed PMID: 9089422.

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