57452-98-9|(R)-Praziquantel|(11bR)-2-(Cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one|-范德生物科技公司

(R)-Praziquantel

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names：
(11bR)-2-(Cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
CAS号：
57452-98-9
MDL Number：
MF(分子式)： C19H24N2O2 MW(分子量)： 312.41
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	(11bR)-2-(Cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
英文别名	(R)-Praziquantel; (R)Praziquantel; (R) Praziquantel; R-Praziquantel; R Praziquantel; (R)-PZQ; (R) PZQ; (R)PZQ; (-)-Praziquantel; (-) Praziquantel; arpraziquantel
CAS号	57452-98-9
SMILES	O=C1CN(C(C2CCCCC2)=O)C[C@]3([H])N1CCC4=C3C=CC=C4
Inchi	InChI=1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2/t17-/m0/s1
InchiKey	FSVJFNAIGNNGKK-KRWDZBQOSA-N
分子式 Formula	C19H24N2O2
分子量 Molecular Weight	312.41
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	(R)-Praziquantel(CAS:57452-98-9):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	(R)-Praziquantel is an active enantiomer of praziquantel that acts as a potent anthelmintic.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Bowman DD, Drake J. Examination of the "susceptibility gap" in the treatment of canine heartworm infection. Parasit Vectors. 2017 Nov 9;10(Suppl 2):513. doi: 10.1186/s13071-017-2433-9. Review. PubMed PMID: 29143689; PubMed Central PMCID: PMC5688481.

[2]da Silva VBR, Campos BRKL, de Oliveira JF, Decout JL, do Carmo Alves de Lima M. Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine. Bioorg Med Chem. 2017 Jul 1;25(13):3259-3277. doi: 10.1016/j.bmc.2017.04.031. Epub 2017 Apr 27. Review. PubMed PMID: 28495384.

[3] Bustinduy AL, Wright S, Joekes EC, Kabatereine NB, Reinhard-Rupp J, King CH, Stothard JR. One hundred years of neglect in paediatric schistosomiasis. Parasitology. 2017 Oct;144(12):1613-1623. doi: 10.1017/S0031182017000014. Epub 2017 Mar 1. Review. PubMed PMID: 28245890.

[4] Price A, Verma A, Welfare W. Are health education interventions effective for the control and prevention of urogenital schistosomiasis in sub-Saharan Africa? A systematic review. Trans R Soc Trop Med Hyg. 2015 Apr;109(4):239-44. doi: 10.1093/trstmh/trv008. Epub 2015 Feb 10. Review. PubMed PMID: 25669840.

[5] Olliaro P, Delgado-Romero P, Keiser J. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer). J Antimicrob Chemother. 2014 Apr;69(4):863-70. doi: 10.1093/jac/dkt491. Epub 2014 Jan 2. Review. PubMed PMID: 24390933.

6: Xiao SH, Keiser J, Chen MG, Tanner M, Utzinger J. Research and development of antischistosomal drugs in the People's Republic of China a 60-year review. Adv Parasitol. 2010;7

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