139446-71-2|Ranakinin|Lys-pro-asn-pro-glu-arg-phe-tyr-gly-leu-met-NH2|-范德生物科技公司

Ranakinin

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names：
Lys-pro-asn-pro-glu-arg-phe-tyr-gly-leu-met-NH2
CAS号：
139446-71-2
MDL Number：
MF(分子式)： C62H95N17O15S MW(分子量)： 1350.606
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Lys-pro-asn-pro-glu-arg-phe-tyr-gly-leu-met-NH2
英文别名	Ranakinin
CAS号	139446-71-2
SMILES	O=C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(C=C4)O)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Inchi	InChI=1S/C62H95N17O15S/c1-35(2)30-43(56(89)72-40(52(66)85)24-29-95-3)71-50(82)34-70-53(86)44(32-37-18-20-38(80)21-19-37)75-57(90)45(31-36-12-5-4-6-13-36)76-54(87)41(15-9-26-69-62(67)68)73-55(88)42(22-23-51(83)84)74-58(91)48-17-11-28-79(48)61(94)46(33-49(65)81)77-59(92)47-16-10-27-78(47)60(93)39(64)14-7-8-25-63/h4-6,12-13,18-21,35,39-48,80H,7-11,14-17,22-34,63-64H2,1-3H3,(H2,65,81)(H2,66,85)(H,70,86)(H,71,82)(H,72,89)(H,73,88)(H,74,91)(H,75,90)(H,76,87)(H,77,92)(H,83,84)(H4,67,68,69)/t39-,40-,41-,42-,43-,44-,45-,46-,47-,48-/m0/s1
InchiKey	YTZYDDAKFLJJQR-BHEJXMHWSA-N
分子式 Formula	C62H95N17O15S
分子量 Molecular Weight	1350.606
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Ranakinin(CAS:139446-71-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Ranakinin is a novel tachykinin receptor agonist; from the brain of frog, Rana ridibunda.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Zhang B, Zhang X, Yang Y, Hu Y, Wang H. Identification and Functional Analysis of Novel Bradykinin-Related Peptides (BRPs) from Skin Secretions of Five Asian Frogs. Protein J. 2018 Aug;37(4):324-332. doi: 10.1007/s10930-018-9783-9. PubMed PMID: 30008150.

[2]Liu X, You D, Chen L, Wang X, Zhang K, Lai R. A novel bradykinin-like peptide from skin secretions of the frog, Rana nigrovittata. J Pept Sci. 2008 May;14(5):626-30. PubMed PMID: 17994619.

[3] Liu L, Murray M, Conlon JM, Burcher E. Quantitative structure-activity analyses of bufokinin and other tachykinins at bufokinin (bNK1) receptors of the small intestine of the cane toad, Bufo marinus. Biochem Pharmacol. 2005 Jan 15;69(2):329-38. Epub 2004 Dec 1. PubMed PMID: 15627485.

[4] Liu L, Murray M, Burcher E. Structure-activity studies of bufokinin, substance P and their C-terminal fragments at bufokinin receptors in the small intestine of the cane toad, Bufo marinus. Biochem Pharmacol. 2002 Jan 15;63(2):217-24. PubMed PMID: 11841796.

[5] Lippe C, Lobasso S, Cassano G, Bellantuono V, Ardizzone C. Actions of tachykinins on the ion transport across the frog skin. Peptides. 1998;19(8):1435-8. PubMed PMID: 9809659.

6: Burcher E, Warner FJ. Tachykinin receptors in the small intestine of the cane toad (Bufo marinus): a radioligand binding and functional study. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jun;357(6):692-700. PubMed PMID: 9686947.7: Kodjo MK, Desrues L, Lavagno L, Fasolo A, Conlon JM, Tonon MC, Vaudry H. Ranakinin, a naturally occurring tachykinin, stimulates phospholipase C activity in the frog adrenal gland. Endocrinology. 1998 Feb;139(2):505-12. PubMed PMID: 9449618.8: Kodjo MK, Leboulenger F, Morra M, Conlon JM, Vaudry H. Pharmacological profile of the tachykinin receptor involved in the stimulation of corticosteroid secretion in the frog Rana ridibunda. J Steroid Biochem Mol Biol. 1996 Mar;57(5-6):329-35. PubMed PMID: 8639469.9: Kodjo MK, Leboulenger F, Conlon JM, Vaudry H. Effect of ranakinin, a novel tachykinin, on cytosolic free calcium in frog adrenochromaffin cells. Endocrinology. 1995 Oct;136(10):4535-42. PubMed PMID: 7664674.10: Kodjo MK, Leboulenger F, Porcedda P, Lamacz M, Conlon JM, Pelletier G, Vaudry H. Evidence for the involvement of chromaffin cells in the stimulatory effect of tachykinins on corticosteroid secretion by the frog adrenal gland. Endocrinology. 1995 Aug;136(8):3253-9. PubMed PMID: 7628358.1

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