116507-04-1|L 658758|((6R,7S)-3-(acetoxymethyl)-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyl)-L-proline|-范德生物科技公司

L 658758

NMR下载 COA and HPLC MSDS下载
names：
((6R,7S)-3-(acetoxymethyl)-7-methoxy-5,5-dioxido-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbonyl)-L-proline
CAS号：
116507-04-1
MDL Number：
MF(分子式)： C16H20N2O9S MW(分子量)： 416.4
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	L 658758
英文别名	L 658758; L-658758; L658758; L-658,758; L 658,758; L658,758;
CAS号	116507-04-1
SMILES	O=C(O)[C@H]1N(C(C(N2C3=O)=C(COC(C)=O)CS([C@]2([H])[C@H]3OC)(=O)=O)=O)CCC1
Inchi	InChI=1S/C16H20N2O9S/c1-8(19)27-6-9-7-28(24,25)15-12(26-2)14(21)18(15)11(9)13(20)17-5-3-4-10(17)16(22)23/h10,12,15H,3-7H2,1-2H3,(H,22,23)/t10-,12-,15+/m0/s1
InchiKey	SMZXYXKZTNLAKY-ITDIGPHOSA-N
分子式 Formula	C16H20N2O9S
分子量 Molecular Weight	416.4
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	L 658758(CAS:116507-04-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	L 658758 is a Serine Proteinase Inhibitor.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Kawai M, Harada N, Takeyama H, Okajima K. Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats. Transl Res. 2010 Jun;155(6):294-304. doi: 10.1016/j.trsl.2010.02.003. Epub 2010 Mar 19. PubMed PMID: 20478544.

[2]Harada N, Okajima K, Isobe H. Role of neutrophil elastase in development of pulmonary vascular injury and septic shock in rats. Shock. 2008 Oct;30(4):379-87. doi: 10.1097/SHK.0b013e3181673e2c. Erratum in: Shock. 2012 Oct;38(4):446. PubMed PMID: 18323746.

[3] Okajima K, Harada N, Uchiba M, Mori M. Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1116-23. Epub 2004 Jul 8. PubMed PMID: 15246960.

[4] Liu W, Okajima K, Murakami K, Harada N, Isobe H, Irie T. Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. J Lab Clin Med. 1998 Nov;132(5):432-9. PubMed PMID: 9823937.

[5] Carden D, Xiao F, Moak C, Willis BH, Robinson-Jackson S, Alexander S. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998 Aug;275(2 Pt 2):H385-92. PubMed PMID: 9683424.

6: Taoka Y, Okajima K, Murakami K, Johno M, Naruo M. Role of neutrophil elastase in compression-induced spinal cord injury in rats. Brain Res. 1998 Jul 20;799(2):264-9. Erratum in: Brain Res. 2011 Aug 23;1408:98. PubMed PMID: 9675307.7: Rees DD, Brain JD, Wohl ME, Humes JL, Mumford RA. Inhibition of neutrophil elastase in CF sputum by L-658,758. J Pharmacol Exp Ther. 1997 Dec;283(3):1201-6. PubMed PMID: 9399994.8: Murakami K, Okajima K, Uchiba M, Harada N, Liu W, Okabe H, Takatsuki K. Role of granulocyte elastase in indomethacin-induced gastric mucosal lesion formation in rats. J Lab Clin Med. 1997 Sep;130(3):307-13. PubMed PMID: 9341991.9: Carden DL, Korthuis RJ. Protease inhibition attenuates microvascular dysfunction in postischemic skeletal muscle. Am J Physiol. 1996 Nov;271(5 Pt 2):H1947-52. PubMed PMID: 8945913.10: Fletcher DS, Osinga DG, Keenan K, Bonney RJ, Doherty JB, Finke PE, Shah SK, Davies P. An inhibitor of leukocyte elastase prevents immune complex-mediated hemorrhage in the rat lung. J Pharmacol Exp Ther. 1995 Jul;274(1):548-54. PubMed PMID: 7616444.1

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