148152-77-6|Jtp 2942|(S)-1-(((S)-1-methyl-3-oxocyclopentane-1-carbonyl)-L-histidyl)pyrrolidine-2-carboxamide|-范德生物科技公司

Jtp 2942

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names：
(S)-1-(((S)-1-methyl-3-oxocyclopentane-1-carbonyl)-L-histidyl)pyrrolidine-2-carboxamide
CAS号：
148152-77-6
MDL Number：
MF(分子式)： C18H25N5O4 MW(分子量)： 375.42
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Jtp 2942
英文别名	Jtp 2942; Jtp-2942; Jtp2942;
CAS号	148152-77-6
SMILES	O=C(N)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@@]3(C)CCC(C3)=O)=O)=O)CCC1
Inchi	InChI=1S/C18H25N5O4/c1-18(5-4-12(24)8-18)17(27)22-13(7-11-9-20-10-21-11)16(26)23-6-2-3-14(23)15(19)25/h9-10,13-14H,2-8H2,1H3,(H2,19,25)(H,20,21)(H,22,27)/t13-,14-,18-/m0/s1
InchiKey	QATMSFATAIOXJC-DEYYWGMASA-N
分子式 Formula	C18H25N5O4
分子量 Molecular Weight	375.42
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Jtp 2942(CAS:148152-77-6):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Jtp 2942 is a novel thyrotropin-releasing hormone analogue.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Ikeda K, Iwasaki Y, Kinoshita M. JTP-2942, a novel thyrotropin-releasing hormone analogue, protects against spinal motor neuron degeneration in the wobbler mouse. Neurosci Lett. 1998 Jun 26;250(1):9-12. PubMed PMID: 9696053.

[2]Matsushita M, Yonemori F, Hamada A, Toide K, Iwata K. Effect of JTP-2942, a novel thyrotropin-releasing hormone analogue, on pentobarbital-induced anesthesia in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):177-82. PubMed PMID: 7781687.

[3] Katsumata T, Katayama Y, Yonemori H, Muramatsu H, Otori T, Nishiyama Y, Yamada H, Nakamura H, Terashi A. Delayed administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, improves cerebral blood flow and metabolism in rat postischaemic brain. Clin Exp Pharmacol Physiol. 2001 Jan-Feb;28(1-2):48-54. PubMed PMID: 11153536.

[4] Urayama A, Yamada S, Deguchi Y, Kimura R, Maeda Y, Kobayashi T. Brain receptor binding characteristics and pharmacokinetics of JTP-2942, a novel thyrotropin-releasing hormone (TRH) analogue. Life Sci. 1999;65(22):2407-15. PubMed PMID: 10597895.

[5] Katsumata T, Katayama Y, Ootori T, Muramatsu H, Nishiyama Y, Nakamura H, Seta T, Terashi A. Effect of long-term administration of JTP-2942, a novel thyrotropin-releasing hormone analogue, on neurological outcome, local cerebral blood flow and glucose utilization in a rat focal cerebral ischemia. Brain Res. 2001 May 18;901(1-2):62-70. PubMed PMID: 11368951.

6: Toide K, Shinoda M, Takase M, Iwata K, Yoshida H. Effects of a novel thyrotropin-releasing hormone analogue, JTP-2942, on extracellular acetylcholine and choline levels in the rat frontal cortex and hippocampus. Eur J Pharmacol. 1993 Mar 16;233(1):21-8. PubMed PMID: 8472746.7: Yonemori F, Yamaguchi T, Nakayama H, Narita K, Hojo S, Tamura A. Effect of JTP-2942, a novel thyrotropin-releasing hormone analog, on motor deficits after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Jan;20(1):74-81. PubMed PMID: 10616795.8: Matsushita M, Yonemori F, Ohta A, Iwata K. Mechanism of the hyperthermic effect of the novel thyrotropin-releasing hormone analogue Na-((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L- prolinamide monohydrate in mice with reserpine-induced hypothermia. Arzneimittelforschung. 1995 Jun;45(6):708-11. PubMed PMID: 7646576.9: Matsushita M, Yonemori F, Furukawa N, Ohta A, Toide K, Uchida I, Iwata K. Effects of the novel thyrotropin-releasing hormone analogue Na -((1S,2R)-2-methyl-4-oxocyclopentylcarbonyl)-L-histidyl-L-prol ina mide monohydrate on the central nervous system in mice and rats. Arzneimittelforschung. 1993 Aug;43(8):813-7. PubMed PMID: 8216433.

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