129551-91-3|JM-221|Platinum, amminebis(butanoato-O)dichloro(cyclohexanamine)-, (OC-6-43)-|-范德生物科技公司

JM-221

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names：
Platinum, amminebis(butanoato-O)dichloro(cyclohexanamine)-, (OC-6-43)-
CAS号：
129551-91-3
MDL Number：
MF(分子式)： C14H30Cl2N2O4Pt MW(分子量)： 556.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	JM-221
英文别名	JM-221, JM 221, JM221
CAS号	129551-91-3
SMILES	[O-]C(CCC)=O.[O-]C(=O)CCC.C1CCCC(C1)N.[ClH-].N.[ClH-].[Pt+4]
Inchi	1S/C6H13N.2C4H8O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;21-2-3-4(5)6;;;;/h6H,1-5,7H2;22-3H2,1H3,(H,5,6);2*1H;1H3;/q;;;;;;+4/p-4
InchiKey	XMOWMXXEICQRQH-UHFFFAOYSA-J
分子式 Formula	C14H30Cl2N2O4Pt
分子量 Molecular Weight	556.39
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	JM-221(CAS:129551-91-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	JM-221 is a novel platinum(IV) dicarboxylate complex exhibiting enhanced cytotoxicity in human ovarian carcinoma cell line when compared to Cisplatin. Comparison with platinum accumulation from Cisplatin suggests that the increased cytotoxicity of JM-221 may be related to increased accumulation within the cell. JM-221 is more lipophilic than Cisplatin, which may account for improved uptake in Cisplatin resistant cells.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Orr RM, O'Neill CF, Nicolson MC, Barnard CF, Murrer BA, Giandomenico CM, Vollano JF, Harrap KR. Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin. Br J Cancer. 1994 Sep;70(3):415-20. PubMed PMID: 8080724; PubMed Central PMCID: PMC2033379.

[2]McKeage MJ, Abel G, Kelland LR, Harrap KR. Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro. Br J Cancer. 1994 Jan;69(1):1-7. PubMed PMID: 8286188; PubMed Central PMCID: PMC1968778.

[3] Mellish KJ, Kelland LR, Harrap KR. In vitro platinum drug chemosensitivity of human cervical squamous cell carcinoma cell lines with intrinsic and acquired resistance to cisplatin. Br J Cancer. 1993 Aug;68(2):240-50. PubMed PMID: 8347478; PubMed Central PMCID: PMC1968570.

[4] Kelland LR, Murrer BA, Abel G, Giandomenico CM, Mistry P, Harrap KR. Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 1992 Feb 15;52(4):822-8. PubMed PMID: 1737343.

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