100643-96-7|Indolidan|2H-Indol-2-one, 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-|-范德生物科技公司

Indolidan

NMR下载 COA and HPLC MSDS下载
names：
2H-Indol-2-one, 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-
CAS号：
100643-96-7
MDL Number：
MF(分子式)： C14H15N3O2 MW(分子量)： 257.293
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Indolidan
英文别名	Indolidan
CAS号	100643-96-7
SMILES	O=C1NC2=C(C=C(C(CC3)=NNC3=O)C=C2)C1(C)C
Inchi	InChI=1S/C14H15N3O2/c1-14(2)9-7-8(3-4-11(9)15-13(14)19)10-5-6-12(18)17-16-10/h3-4,7H,5-6H2,1-2H3,(H,15,19)(H,17,18)
InchiKey	LZCQFJKUAIWHRW-UHFFFAOYSA-N
分子式 Formula	C14H15N3O2
分子量 Molecular Weight	257.293
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Indolidan(CAS:100643-96-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Indolidan is a cardiotonic.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Haynes J Jr, Obiako B, Babal P, Stevens T. 5-(N-ethylcarboxamido)adenosine desensitizes the A2b-adenosine receptor in lung circulation. Am J Physiol. 1999 Jun;276(6 Pt 2):H1877-83. PubMed PMID: 10362666.

[2]Naka Y, Roy DK, Liao H, Chowdhury NC, Michler RE, Oz MC, Pinsky DJ. cAMP-mediated vascular protection in an orthotopic rat lung transplant model. Insights into the mechanism of action of prostaglandin E1 to improve lung preservation. Circ Res. 1996 Oct;79(4):773-83. PubMed PMID: 8831501.

[3] Ashikaga T, Robertson DW, Sportsman RJ, Strada SJ, Thompson WJ. Comparison of indolidan analog binding sites of drug antibody and sarcoplasmic reticulum with inhibition of cyclic AMP phosphodiesterase. J Recept Signal Transduct Res. 1996 Sep-Nov;16(5-6):315-37. PubMed PMID: 8968964.

[4] Rousseau E, Dostie J, Taoudi-Benchekroun M, Cadieux A, Beaudry C, Lugnier C. Specific cyclic nucleotide phosphodiesterase inhibitors differently modulate contractile kinetics in airway smooth muscle. Can J Physiol Pharmacol. 1995 Dec;73(12):1784-94. PubMed PMID: 8834493.

[5] Tischler AS, Riseberg JC, Gray R. Mitogenic and antimitogenic effects of pituitary adenylate cyclase-activating polypeptide (PACAP) in adult rat chromaffin cell cultures. Neurosci Lett. 1995 Apr 21;189(3):135-8. PubMed PMID: 7624029.

6: Draijer R, Atsma DE, van der Laarse A, van Hinsbergh VW. cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells. Circ Res. 1995 Feb;76(2):199-208. PubMed PMID: 7834830.7: Rousseau E, Gagnon J, Lugnier C. Biochemical and pharmacological characterization of cyclic nucleotide phosphodiesterase in airway epithelium. Mol Cell Biochem. 1994 Nov 23;140(2):171-5. PubMed PMID: 7898488.8: Pinsky D, Oz M, Liao H, Morris S, Brett J, Sciacca R, Karakurum M, Van Lookeren Campagne M, Platt J, Nowygrod R, et al. Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model. J Clin Invest. 1993 Dec;92(6):2994-3002. PubMed PMID: 8254053; PubMed Central PMCID: PMC288503.9: Sandusky GE, Means JR, Yeager HK. Coronary artery toxicity in beagle dogs given indolidan, a type III phosphodiesterase inhibitor. Fundam Appl Toxicol. 1993 Aug;21(2):228-35. PubMed PMID: 8405786.10: Lugnier C, Muller B, Le Bec A, Beaudry C, Rousseau E. Characterization of indolidan- and rolipram-sensitive cyclic nucleotide phosphodiesterases in canine and human cardiac microsomal fractions. J Pharmacol Exp Ther. 1993 Jun;265(3):1142-51. PubMed PMID: 8389853.1

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