1420-08-2|Desacetamidocolchicine|Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-|-范德生物科技公司

Desacetamidocolchicine

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names：
Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-
CAS号：
1420-08-2
MDL Number：
MF(分子式)： C20H22O5 MW(分子量)： 342.39
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Desacetamidocolchicine
英文别名	Desacetamidocolchicine; Deacetylaminocolchicine; DAAC
CAS号	1420-08-2
SMILES	O=C1C=C2CCCC3=CC(OC)=C(OC)C(OC)=C3C2=CC=C1OC
Inchi	InChI=1S/C20H22O5/c1-22-16-9-8-14-12(10-15(16)21)6-5-7-13-11-17(23-2)19(24-3)20(25-4)18(13)14/h8-11H,5-7H2,1-4H3
InchiKey	IPDJRYUVROTJTO-UHFFFAOYSA-N
分子式 Formula	C20H22O5
分子量 Molecular Weight	342.39
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Desacetamidocolchicine(CAS:1420-08-2):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Desacetamidocolchicine (DAAC) is a colchicine analogue that lacks the acetamido side chain in the ring-B of colchicine. Unlike colchicine, it binds to tubulin very quickly, and yet it has powerful antimitotic properties. It has been demonstrated that the beta-tubulin isoforms differ significantly in their interactions with colchicine.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Roychowdhury M, Sarkar N, Manna T, Bhattacharyya S, Sarkar T, Basusarkar P, Roy S, Bhattacharyya B. Sulfhydryls of tubulin. A probe to detect conformational changes of tubulin. Eur J Biochem. 2000 Jun;267(12):3469-76. PubMed PMID: 10848962.

[2]Banerjee A, D'Hoore A, Engelborghs Y. Interaction of desacetamidocolchicine, a fast binding analogue of colchicine with isotypically pure tubulin dimers alpha beta II, alpha beta III, and alpha beta IV. J Biol Chem. 1994 Apr 8;269(14):10324-9. PubMed PMID: 8144613.

[3] Maity SN, Bhattacharyya B. Properties of B-ring analogues of colchicine. FEBS Lett. 1987 Jun 22;218(1):102-6. PubMed PMID: 3595855.

[4] Ghosh Choudhury G, Maity S, Bhattacharyya B, Biswas BB. B-ring of colchicine and its role in taxol-induced tubulin polymerization. FEBS Lett. 1986 Mar 3;197(1-2):31-4. PubMed PMID: 2868923.

[5] Choudhury GG, Banerjee A, Bhattacharyya B, Biswas BB. Interaction of colchicine analogues with purified tubulin. FEBS Lett. 1983 Sep 5;161(1):55-9. PubMed PMID: 6884527.

6: Ray K, Bhattacharyya B, Biswas BB. Role of B-ring of colchicine in its binding to tubulin. J Biol Chem. 1981 Jun 25;256(12):6241-4. PubMed PMID: 7240202.

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