4914-30-1|Dehydroemetine|2-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-ethyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline|-范德生物科技公司

Dehydroemetine

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names：
2-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-3-ethyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-4H-pyrido[2,1-a]isoquinoline
CAS号：
4914-30-1
MDL Number：
MF(分子式)： C29H38N2O4 MW(分子量)： 478.63
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Dehydroemetine
英文别名	Dehydroemetine; BT 436; BT-436; BT436; Mebadin; Ro 1-9334; Ro-1-9334; Ro1-9334;
CAS号	4914-30-1
SMILES	COC1=CC2=C(C=C1OC)CCNC2CC3=C(CC)CN4CCC5=CC(OC)=C(OC)C=C5C4C3
Inchi	InChI=1S/C29H38N2O4/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24/h13-16,24-25,30H,6-12,17H2,1-5H3
InchiKey	XXLZPUYGHQWHRN-UHFFFAOYSA-N
分子式 Formula	C29H38N2O4
分子量 Molecular Weight	478.63
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Dehydroemetine(CAS:4914-30-1):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Dehydroemetine is a synthetically produced antiprotozoal agent similar to emetine in its anti-amoebic properties and structure.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]POWELL SJ, MACLEOD IN, WILMOT AJ, ELSDON-DEW R. THE TREATMENT OF ACUTE AMOEBIC DYSENTERY: TRIALS OF DEHYDROEMETINE, OF DEHYDROEMETINE-BISMUTH-IODIDE, AND OF DEHYDROEMETINE AND DEHYDROEMETINE-BISMUTH-IODIDE IN COMBINATION. Ann Trop Med Parasitol. 1965 Jun;59:205-7. PubMed PMID: 14345285.

[2]Salako LA. The actions of dehydroemetine on isolated guinea-pig atria. Influence of ouabain and calcium. Br J Pharmacol. 1972 Dec;46(4):725-35. PubMed PMID: 4655270; PubMed Central PMCID: PMC1666376.

[3] Jain NK, Madan A, Sharma TN, Sharma DK, Mandhana RG. Hepatopulmonary amoebiasis. Efficacy of various treatment regimens containing dehydroemetine and/or metronidazole. J Assoc Physicians India. 1990 Apr;38(4):269-71. PubMed PMID: 2202709.

[4] Durotoye AO, Salako LA. The effect of dehydroemetine on isolated guinea-pig atria. Br J Pharmacol. 1972 Apr;44(4):723-31. PubMed PMID: 5041451; PubMed Central PMCID: PMC1665990.

[5] Miller HH, Johnson RK, Donahue JD, Jondorf WR. Hepatic drug-metabolizing enzyme activity in rats pretreated with (-)-emetine or (plus or minus)-2,3-dehydroemetine. Biochem J. 1970 Apr;117(3):491-8. PubMed PMID: 4392930; PubMed Central PMCID: PMC1178951.

6: SARDESAI HV, SULE CR, GAVANKAR SS. Clinical trials with dehydroemetine (Ro 1-9334) in acute amebiasis. Indian J Med Sci. 1963 Apr;17:334-45. PubMed PMID: 13991475.7: NANAVATI MB, DAMANY SJ, JOSHI HD. CLINICAL TRIAL OF DEHYDROEMETINE (RO 1-9334) IN AMOEDIASIS. Indian Pract. 1965 Mar;18:259-63. PubMed PMID: 14292163.8: POWELL SJ, WILMOT AJ, MACLEOD IN, ELSDON-DEW R. DEHYDROEMETINE IN THE TREATMENT OF AMOEBIC LIVER ABSCESS. Ann Trop Med Parasitol. 1965 Jun;59:208-9. PubMed PMID: 14345286.9: KAPADIA RM. CARDIOVASCULAR TOXICITY OF DEHYDROEMETINE IN AMOEBIASIS. J Indian Med Assoc. 1964 Nov 16;4

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