1131-66-4|Debrisoquin hydrobromide|2(1H)-Isoquinolinecarboxamidine, 3,4-dihydro-, hydrobromide|-范德生物科技公司

Debrisoquin hydrobromide

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names：
2(1H)-Isoquinolinecarboxamidine, 3,4-dihydro-, hydrobromide
CAS号：
1131-66-4
MDL Number：
MF(分子式)： C10H14BrN3 MW(分子量)： 256.147
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	Debrisoquin hydrobromide
英文别名	Debrisoquin hydrobromide; Ro 5-3307; Debrisoquin HCl.
CAS号	1131-66-4
Inchi	InChI=1S/C10H13N3.BrH/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13;/h1-4H,5-7H2,(H3,11,12);1H
InchiKey	VTSAHPTZGHRJSO-UHFFFAOYSA-N
分子式 Formula	C10H14BrN3
分子量 Molecular Weight	256.147
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Debrisoquin hydrobromide(CAS:1131-66-4):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Debrisoquin hydrobromide, the hydrobromide salt form of dextromethorphan, a synthetic, methylated dextrorotary analogue of levorphanol, a substance related to codeine and a non-opioid derivate of morphine. Dextromethorphan exhibits antitussive activity and is devoid of analgesic or addictive property. This agent crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the central nervous system, thereby suppressing the cough reflex.
Application1
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危险性	Warning
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备注

[1]Irshaid YM, al-Hadidi HF, Latif A, Awwadi F, al-Zoubi M, Rawashdeh NM. Dextromethorphan metabolism in Jordanians: dissociation of dextromethorphan O-demethylation from debrisoquine 4-hydroxylation. Eur J Drug Metab Pharmacokinet. 1996 Oct-Dec;21(4):301-7. PubMed PMID: 9074894.

[2]Hou ZY, Chen CP, Yang WC, Lai MD, Buchert ET, Chung HM, Pickle LW, Woosley RL. Determination of dextromethorphan metabolic phenotype by salivary analysis with a reference to genotype in Chinese patients receiving renal hemodialysis. Clin Pharmacol Ther. 1996 Apr;59(4):411-7. PubMed PMID: 8612385.

[3] Hou ZY, Pickle LW, Meyer PS, Woosley RL. Salivary analysis for determination of dextromethorphan metabolic phenotype. Clin Pharmacol Ther. 1991 Apr;49(4):410-9. PubMed PMID: 2015730.

[4] Schmid B, Bircher J, Preisig R, Küpfer A. Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation. Clin Pharmacol Ther. 1985 Dec;38(6):618-24. PubMed PMID: 4064464.

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