140466-18-8|CL-184005|2-(methoxycarbonyl)-3-(tetradecyloxy)phenyl (3-((5-methylthiazol-3-ium-3-yl)methyl)phenyl) phosphate|-范德生物科技公司

CL-184005

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names：
2-(methoxycarbonyl)-3-(tetradecyloxy)phenyl (3-((5-methylthiazol-3-ium-3-yl)methyl)phenyl) phosphate
CAS号：
140466-18-8
MDL Number：
MF(分子式)： C33H46NO7PS MW(分子量)： 631.7648
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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询价

中文别名	CL-184005
英文别名	CL-184005; CL 184005; CL184005
CAS号	140466-18-8
SMILES	CC1=C[N+](CC2=CC=CC(OP(OC3=CC=CC(OCCCCCCCCCCCCCC)=C3C(OC)=O)([O-])=O)=C2)=CS1
Inchi	InChI=1S/C33H46NO7PS/c1-4-5-6-7-8-9-10-11-12-13-14-15-22-39-30-20-17-21-31(32(30)33(35)38-3)41-42(36,37)40-29-19-16-18-28(23-29)25-34-24-27(2)43-26-34/h16-21,23-24,26H,4-15,22,25H2,1-3H3
InchiKey	VGVUQNMRGKNUJA-UHFFFAOYSA-N
分子式 Formula	C33H46NO7PS
分子量 Molecular Weight	631.7648
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	CL-184005(CAS:140466-18-8):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	CL-184005 is a platelet activating factor (PAF) inhibitor potentially for the treatment of gram-negative bacterial infection and septic shock. CL-184005 interferes with tumor necrosis factor synthesis induced by S. aureus. Spleen-associated tumor necrosis factor protein was also decreased by pretreatment with CL-184005.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Negro Alvarez JM, Miralles López JC, Ortiz Martínez JL, Abellán Alemán A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010.

[2]Chen J, Giris N. Species differences in PAF receptor binding in the lungs between hamster and guinea pig. J Lipid Mediat Cell Signal. 1997 Jun;16(2):63-74. PubMed PMID: 9172049.

[3] Dirkes K, Harris BH, Connolly RJ, Schwaitzberg SD, Dinarello CA, Gelfand JA. Platelet activating factor-antagonist improves survival in experimental staphylococcal septicemia. J Pediatr Surg. 1994 Aug;29(8):1055-7; discussion 1057-8. PubMed PMID: 7965505.

[4] DeJoy SQ, Jeyaseelan R Sr, Torley LW, Pickett WC, Wissner A, Wick MM, Oronsky AL, Kerwar SS. Effect of CL 184,005, a platelet-activating factor antagonist in a murine model of Staphylococcus aureus-induced gram-positive sepsis. J Infect Dis. 1994 Jan;169(1):150-6. PubMed PMID: 8277176.

[5] Tao W, Dougherty R, Johnston P, Pickett W. Recombinant bovine GM-CSF primes superoxide production but not degranulation induced by recombinant bovine interleukin-1 beta in bovine neutrophils. J Leukoc Biol. 1993 Jun;53(6):679-84. PubMed PMID: 8391055.

6: Torley LW, Pickett WC, Carroll ML, Kohler CA, Schaub RE, Wissner A, DeJoy SQ, Oronsky AL, Kerwar SS. Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. Antimicrob Agents Chemother. 1992 Sep;36(9):1971-7. PubMed PMID: 1416889; PubMed Central PMCID: PMC192217.7: Wissner A, Carroll ML, Green KE, Kerwar SS, Pickett WC, Schaub RE, Torley LW, Wrenn S, Kohler CA. Analogues of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor. J Med Chem. 1992 May 1;35(9):1650-62. PubMed PMID: 1578493.

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