1045-29-0|Anordiol|Dicyclopenta(a,f)naphthalene-1,7-diol, 1,7-diethynylhexadecahydro-8a,10a-dimethyl-, (1R-(1alpha,3abeta,3balpha,5abeta,7alpha,8aalpha,8bbeta,10aalpha))-|-范德生物科技公司

Anordiol

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names：
Dicyclopenta(a,f)naphthalene-1,7-diol, 1,7-diethynylhexadecahydro-8a,10a-dimethyl-, (1R-(1alpha,3abeta,3balpha,5abeta,7alpha,8aalpha,8bbeta,10aalpha))-
CAS号：
1045-29-0
MDL Number：
MF(分子式)： C22H30O2 MW(分子量)： 326.48
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Anordiol
英文别名	Anordiol; AF 45; AF45; AF-45; H 241; H241; H-241
CAS号	1045-29-0
Inchi	InChI=1S/C22H30O2/c1-5-21(23)13-15-7-8-16-17(19(15,3)14-21)9-11-20(4)18(16)10-12-22(20,24)6-2/h1-2,15-18,23-24H,7-14H2,3-4H3/t15-,16+,17-,18-,19-,20-,21+,22-/m0/s1
InchiKey	HUUUMTTWAPMBMU-ZBJWQKIUSA-N
分子式 Formula	C22H30O2
分子量 Molecular Weight	326.48
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Anordiol(CAS:1045-29-0):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Anordiol, the dihydroxylated metabolite of anordrin, is an antiestrogen with estrogenic activity that is known to inhibit fertility.
Application1
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警示图
危险性	Warning
危险性警示
安全声明
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备注

[1]Ma B, Xiang Y, Mu SM, Li T, Yu HM, Li XJ. Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte. Acta Pharmacol Sin. 2004 Jan;25(1):90-7. PubMed PMID: 14704128.

[2]Dao B, Vanage G, Li XJ, Bardin CW, Koide SS. Comparative effectiveness of three antiprogestins alone and in combination with anordiol in terminating pregnancy in the rat. Contraception. 1997 Jan;55(1):35-40. PubMed PMID: 9013059.

[3] Li XJ, Yu H, Koide SS. Effect of mifepristone and antiestrogens on uterine PGF2 alpha and PGE2 concentrations in ovariectomized and pregnant rats. Prostaglandins. 1997 Mar;53(3):187-97. PubMed PMID: 9206800.

[4] Wang WC, Chang CC, Bardin CW. Anordiol is more potent than anordrin for terminating pregnancy when administered with RU 486. Contraception. 1993 Jun;47(6):609-16. PubMed PMID: 8334895.

[5] Juneja SC, Williams RS. Effect of anordrin on the development of mouse preimplantation embryos in vitro. J Assist Reprod Genet. 1996 Apr;13(4):356-62. PubMed PMID: 8777353.

6: Kaplan-Kraicer R, Bardin CW, Shalgi R. Anordiol and RU486 synergize to produce preimplantation pregnancy loss by increasing embryo transport (rat). Contraception. 1995 Feb;51(2):141-6. PubMed PMID: 7750292.7: Kaplan-Kraicer R, Shinnar N, Bardin CW, Shalgi R. Anordiol produces pregnancy loss in the rat--via the embryo or via the uterus? Contraception. 2000 May;61(5):341-6. PubMed PMID: 10906506.8: Chatterton RT Jr, Berman C, Walters NN. Anti-uterotrophic and folliculostatic activities of anordiol (2 alpha,17 alpha-diethynyl-A-nor-5 alpha-androstane-2 beta,17 beta-diol). Contraception. 1989 Mar;39(3):291-7. PubMed PMID: 2714089.9: Peters AJ, Wentz AC, Kazer RR, Jeyendran RS, Chatterton RT Jr. Estrogenic and antiestrogenic activities of anordiol: a comparison of uterine and vaginal responses with those of clomiphene citrate. Contraception. 1995 Sep;52(3):195-202. PubMed PMID: 7587192.10: Vanage GR, Dao B, Li XJ, Bardin CW, Koide SS. Effects of anordiol, an antiestrogen, on the reproductive organs of the male rat. Arch Androl. 1997 Jan-Feb;38(1):13-21. PubMed PMID: 9017118.1

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