37380-45-3|AN 9|(pivaloyloxy)methyl butyrate|-范德生物科技公司

AN 9

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names：
(pivaloyloxy)methyl butyrate
CAS号：
37380-45-3
MDL Number：
MF(分子式)： C10H18O4 MW(分子量)： 202.25
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	AN 9
英文别名	AN 9, AN-9, AN9, AN 9 (ion exchanger)
CAS号	37380-45-3
SMILES	CCCC(=O)OCOC(=O)C(C)(C)C
Inchi	1S/C10H18O4/c1-5-6-8(11)13-7-14-9(12)10(2,3)4/h5-7H2,1-4H3
InchiKey	GYKLFBYWXZYSOW-UHFFFAOYSA-N
分子式 Formula	C10H18O4
分子量 Molecular Weight	202.25
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	AN 9(CAS:37380-45-3):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	AN 9, also known as pivaloyloxymethyl butyrate, is a butyric acid derivative previously shown to be a potent differentiating agent. AN-9 exerts significant anticancer activity in vitro and in vivo. AN-9 induces cell death by apoptosis. Apoptosis by AN-9 was accompanied by reduction in Bcl-2 expression. Preincubation with antioxidants did not protect HL-60 cells from apoptosis induced by AN-9. In one study, HL-60 cells that were induced to differentiate by preincubation with retinoic acid or low AN-9 concentrations were more resistant to apoptosis, induced later by high concentrations of AN-9, than were undifferentiated cells.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Tarasenko N, Nudelman A, Tarasenko I, Entin-Meer M, Hass-Kogan D, Inbal A, Rephaeli A. Histone deacetylase inhibitors: the anticancer, antimetastatic and antiangiogenic activities of AN-7 are superior to those of the clinically tested AN-9 (Pivanex). Clin Exp Metastasis. 2008;25(7):703-16. doi: 10.1007/s10585-008-9179-x. Epub 2008 May 28. PubMed PMID: 18506586.

[2]Blank-Porat D, Gruss-Fischer T, Tarasenko N, Malik Z, Nudelman A, Rephaeli A. The anticancer prodrugs of butyric acid AN-7 and AN-9, possess antiangiogenic properties. Cancer Lett. 2007 Oct 18;256(1):39-48. Epub 2007 Jul 3. PubMed PMID: 17611019.

[3] Parker BS, Rephaeli A, Nudelman A, Phillips DR, Cutts SM. Formation of mitoxantrone adducts in human tumor cells: potentiation by AN-9 and DNA methylation. Oncol Res. 2004;14(6):279-90. PubMed PMID: 15206490.

[4] Batova A, Shao LE, Diccianni MB, Yu AL, Tanaka T, Rephaeli A, Nudelman A, Yu J. The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Blood. 2002 Nov 1;100(9):3319-24. PubMed PMID: 12384433.

[5] Zimra Y, Wasserman L, Maron L, Shaklai M, Nudelman A, Rephaeli A. Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells. J Cancer Res Clin Oncol. 1997;123(3):152-60. PubMed PMID: 9119880.

6: Kasukabe T, Rephaeli A, Honma Y. An anti-cancer derivative of butyric acid (pivalyloxmethyl buterate) and daunorubicin cooperatively prolong survival of mice inoculated with monocytic leukaemia cells. Br J Cancer. 1997;75(6):850-4. PubMed PMID: 9062406; PubMed Central PMCID: PMC2063395.

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