213549-32-7|Agosterol A|Cholest-7-ene-3,4,6,11,22-pentol, 3,4,6-triacetate, (3beta,4beta,5alpha,6alpha,11alpha,22R)-|-范德生物科技公司

Agosterol A

NMR下载 COA and HPLC MSDS下载
names：
Cholest-7-ene-3,4,6,11,22-pentol, 3,4,6-triacetate, (3beta,4beta,5alpha,6alpha,11alpha,22R)-
CAS号：
213549-32-7
MDL Number：
MF(分子式)： C33H52O8 MW(分子量)： 576.77
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	Agosterol A
英文别名	Agosterol A;
CAS号	213549-32-7
SMILES	CC(C)CC[C@@H](O)[C@@H](C)[C@H]1CC[C@@]2([H])C3=C[C@H](OC(C)=O)[C@@]4([H])[C@@H](OC(C)=O)[C@@H](OC(C)=O)CC[C@]4(C)[C@@]3([H])[C@H](O)C[C@]12C
Inchi	InChI=1S/C33H52O8/c1-17(2)9-12-25(37)18(3)23-10-11-24-22-15-28(40-20(5)35)30-31(41-21(6)36)27(39-19(4)34)13-14-32(30,7)29(22)26(38)16-33(23,24)8/h15,17-18,23-31,37-38H,9-14,16H2,1-8H3/t18-,23+,24-,25+,26+,27-,28-,29+,30-,31-,32+,33+/m0/s1
InchiKey	SUIRSZOPEPPNGJ-JGEDILIOSA-N
分子式 Formula	C33H52O8
分子量 Molecular Weight	576.77
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	Agosterol A(CAS:213549-32-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	Agosterol A is extracted from marine sponge Spongia.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

[1]Abraham I, El Sayed K, Chen ZS, Guo H. Current status on marine products with reversal effect on cancer multidrug resistance. Mar Drugs. 2012 Oct;10(10):2312-2[1]doi: 10.3390/md10102312. Epub 2012 Oct 19. Review. PubMed PMID: 23170086; PubMed Central PMCID: PMC3497025.

[2]Ren XQ, Furukawa T, Yamamoto M, Aoki S, Kobayashi M, Nakagawa M, Akiyama S. A functional role of intracellular loops of human multidrug resistance protein 1. J Biochem. 2006 Sep;140(3):313-8. Epub 2006 Jul 21. PubMed PMID: 16861249.

[3] Noguchi T, Ren XQ, Aoki S, Igarashi Y, Che XF, Nakajima Y, Takahashi H, Mitsuo R, Tsujikawa K, Sumizawa T, Haraguchi M, Kobayashi M, Goto S, Kanehisa M, Aikou T, Akiyama S, Furukawa T. MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate). Biochem Pharmacol. 2005 Oct 1;70(7):1056-65. PubMed PMID: 16098482.

[4] Ren XQ, Furukawa T, Nakajima Y, Takahashi H, Aoki S, Sumizawa T, Haraguchi M, Kobayashi M, Chijiiwa K, Akiyama S. GSH inhibits trypsinization of the C-terminal half of human MRP1. J Biol Chem. 2005 Feb 18;280(7):6231-7. Epub 2004 Dec 3. PubMed PMID: 15579473.

[5] Mitsuo M, Noguchi T, Nakajima Y, Aoki S, Ren XQ, Sumizawa T, Haraguchi M, Kobayashi M, Baba M, Nagata Y, Akiyama S, Furukawa T. Binding site(s) on P-glycoprotein for a newly synthesized photoaffinity analog of agosterol A. Oncol Res. 2003;14(1):39-48. PubMed PMID: 14552590.

6: Ren XQ, Furukawa T, Aoki S, Sumizawa T, Haraguchi M, Che XF, Kobayashi M, Akiyama S. Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1. Br J Pharmacol. 2003 Apr;138(8):1553-61. PubMed PMID: 12721111; PubMed Central PMCID: PMC1573804.7: Ren XQ, Furukawa T, Aoki S, Sumizawa T, Haraguchi M, Nakajima Y, Ikeda R, Kobayashi M, Akiyama S. A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4. Biochemistry. 2002 Dec 3;41(48):14132-40. PubMed PMID: 12450376.8: Che XF, Nakajima Y, Sumizawa T, Ikeda R, Ren XQ, Zheng CL, Mukai M, Furukawa T, Haraguchi M, Gao H, Sugimoto Y, Akiyama S. Reversal of P-glycoprotein mediated multidrug resistance by a newly synthesized 1,4-benzothiazipine derivative, JTV-519. Cancer Lett. 2002 Dec 10;187(1-2):111-9. PubMed PMID: 12359358.9: Aoki S, Chen ZS, Higasiyama K, Setiawan A, Akiyama S, Kobayashi M. Reversing effect of agosterol A, a spongean sterol acetate, on multidrug resistance in human carcinoma cells. Jpn J Cancer Res. 2001 Aug;92(8):886-95. PubMed PMID: 11509122; PubMed Central PMCID: PMC5926837.10: Murakami N, Sugimoto M, Morita M, Kobayashi M. Total synthesis of agosterol A: an MDR-modulator from a marine sponge. Chemistry. 2001 Jun 18;7(12):2663-70. PubMed PMID: 11465457.1

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