132956-87-7|A 71915|L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic (2-13)-disulfide|-范德生物科技公司

A 71915

NMR下载 COA and HPLC MSDS下载
names：
L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic (2-13)-disulfide
CAS号：
132956-87-7
MDL Number：
MF(分子式)： C69H116N26O15S2 MW(分子量)： 1613.97
EINECS: Reaxys Number:
Pubchem ID: Brand:BIOFOUNT

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中文别名	A 71915
英文别名	A 71915; A-71915; A71915
CAS号	132956-87-7
SMILES	O=C([C@@H](NC([C@@H](CCCNC(N)=N)NC(CNC(CNC([C@H](CC1CCCCC1)NC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CSS2)=O)=O)=O)=O)=O)[C@@H](C)CC)N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N3CC4=C(C=CC=C4)C[C@@H]3C(NCC(N[C@H](C(N)=O)[C@H]2CCCNC(N)=N)=O)=O)=O)=O)=O
Inchi	InChI=1S/C69H116N26O15S2/c1-5-36(3)53-64(109)90-45(30-52(99)100)61(106)88-43(22-14-26-82-68(76)77)60(105)94-54(37(4)6-2)65(110)95-34-40-19-11-10-18-39(40)29-47(95)63(108)86-33-51(98)92-55(56(71)101)48(23-15-27-83-69(78)79)112-111-35-46(91-57(102)41(70)20-12-24-80-66(72)73)62(107)89-44(28-38-16-8-7-9-17-38)58(103)85-31-49(96)84-32-50(97)87-42(59(104)93-53)21-13-25-81-67(74)75/h10-11,18-19,36-38,41-48,53-55H,5-9,12-17,20-35,70H2,1-4H3,(H2,71,101)(H,84,96)(H,85,103)(H,86,108)(H,87,97)(H,88,106)(H,89,107)(H,90,109)(H,91,102)(H,92,98)(H,93,104)(H,94,105)(H,99,100)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)(H4,78,79,83)/t36-,37-,41-,42+,43-,44-,45-,46-,47+,48+,53-,54-,55-/m0/s1
InchiKey	TZQXLCWSYQJGKV-YGLLJKSHSA-N
分子式 Formula	C69H116N26O15S2
分子量 Molecular Weight	1613.97
闪点 FP
熔点 Melting point
沸点 Boiling point
Polarizability极化度
密度 Density
蒸汽压 Vapor Pressure
溶解度Solubility
性状	Solid powder
储藏条件 Storage conditions	Dry, dark and store at 0-4℃ for short term (days to weeks) or -20℃ for long term (Store correctly 2-3years).

产品说明	A 71915(CAS:132956-87-7):仅限应用于工业或者科学研究过程中非医疗目的，不应用于人类或动物的临床诊断以及治过程疗，该产品非药用，非食用。
Introduction	A 71915 is an atrial natricuretic factor receptor antagonist. It blocks physiological effects of angiotensin.
Application1
Application2
Application3

警示图
危险性	Warning
危险性警示
安全声明
安全防护
备注

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[2]Zhao J, Liu T, Liu E, Li G, Qi L, Li J. The potential role of atrial natriuretic peptide in the effects of Angiotensin-(1-7) in a chronic atrial tachycardia canine model. J Renin Angiotensin Aldosterone Syst. 2016 Mar 23;17(1):1470320315627409. doi: 10.1177/1470320315627409. Print 2016 Jan-Mar. PubMed PMID: 27009283.

[3] Kiguchi N, Sukhtankar DD, Ding H, Tanaka K, Kishioka S, Peters CM, Ko MC. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. J Pharmacol Exp Ther. 2016 Mar;356(3):596-603. doi: 10.1124/jpet.115.229997. Epub 2015 Dec 15. PubMed PMID: 26669425; PubMed Central PMCID: PMC4767390.

[4] Pandey KN, Nguyen HT, Li M, Boyle JW. Natriuretic peptide receptor-A negatively regulates mitogen-activated protein kinase and proliferation of mesangial cells: role of cGMP-dependent protein kinase. Biochem Biophys Res Commun. 2000 May 10;271(2):374-9. PubMed PMID: 10799305.

[5] Delporte C, Winand J, Poloczek P, Von Geldern T, Christophe J. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur J Pharmacol. 1992 Dec 2;224(2-3):183-8. PubMed PMID: 1334838.

6: Azer J, Hua R, Vella K, Rose RA. Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptors. J Mol Cell Cardiol. 2012 Nov;53(5):715-24. doi: 10.1016/j.yjmcc.2012.08.020. Epub 2012 Aug 30. PubMed PMID: 22960454.7: Kumar R, von Geldern TW, Calle RA, Pandey KN. Stimulation of atrial natriuretic peptide receptor/guanylyl cyclase- A signaling pathway antagonizes the activation of protein kinase C-alpha in murine Leydig cells. Biochim Biophys Acta. 1997 Apr 24;1356(2):221-8. PubMed PMID: 9150279.8: Springer J, Azer J, Hua R, Robbins C, Adamczyk A, McBoyle S, Bissell MB, Rose RA. The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. J Mol Cell Cardiol. 2012 May;52(5):1122-34. doi: 10.1016/j.yjmcc.2012.01.018. Epub 2012 Feb 1. PubMed PMID: 22326431.9: Chaudhary KR, Batchu SN, Das D, Suresh MR, Falck JR, Graves JP, Zeldin DC, Seubert JM. Role of B-type natriuretic peptide in epoxyeicosatrienoic acid-mediated improved post-ischaemic recovery of heart contractile function. Cardiovasc Res. 2009 Jul 15;83(2):362-70. doi: 10.1093/cvr/cvp134. Epub 2009 Apr 28. PubMed PMID: 19401302; PubMed Central PMCID: PMC2701722.10: Ni XP, Kesterson RA, Sharma SD, Hruby VJ, Cone RD, Wiedemann E, Humphreys MH. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. Am J Physiol. 1998 Apr;274(4 Pt 2):R931-8. PubMed PMID: 9575953.1

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