11042-64-1|谷维素|γ-Oryzanol|MFCD00867548-范德生物科技公司

谷维素
NMR and HPLC COA下载 MSDS下载
Names：
γ-Oryzanol
CAS号：
11042-64-1
MDL Number： MFCD00867548
MF(分子式)： C40H58O4 MW(分子量)： 602.89
EINECS:600-960-6 Reaxys Number:No data available
Pubchem ID:5282164 Brand:BIOFOUNT

谷维素(11042-64-1,γ-Oryzanol)可有效抑制小鼠纹状体中的DNA甲基转移酶(DNMTs).谷维素可以抑制DNMT1和DNMT3a,IC₅₀ 分别为3.2μM和22.3μM。谷维素可以降低血液中某些LIPIDS含量的物质。谷维素可用于治疗高脂血症。谷维素是抗溃疡剂，谷维素具有不同作用机制的各种药剂可用于治疗或改善PEPTIC ULCER或胃肠道刺激。其中包括用于治疗幽门螺杆菌感染的抗生素；组胺H2拮抗剂可减少胃酸分泌；和ANTACIDS用于缓解症状。米糠中存在与多种生理功能有关。

货品编码	规格	纯度	价格 (¥)	现价(¥)	特价(¥)	库存描述	数量	总计 (¥)
YZM002871-1g	1g	>95%	¥ 506.00	¥ 506.00		2-3天	- +	¥ 0.00
YZM002871-500mg	500mg	>95%	¥ 390.00	¥ 390.00		2-3天	- +	¥ 0.00

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中文别名	谷维素(11042-64-1,γ-Oryzanol);γ-谷维素;三(3-羟基)4-(4-羟基-3-甲氧基苯基)-2-丙酸酯;
英文别名	γ-Oryzanol(11042-64-1);gamma-oryzanol;oryzanol;triacontane 3-(4-hydroxy-3-methoxyphenyl)-2-propenate
CAS号	11042-64-1
SMILES	C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C5(C)C)OC(=O)/C=C/c6ccc(c(c6)OC)O)C)C
Inchi	InChI=1S/C40H58O4/c1-26(2)10-9-11-27(3)29-18-20-38(7)33-16-15-32-36(4,5)34(19-21-39(32)25-40(33,39)23-22-37(29,38)6)44-35(42)17-13-28-12-14-30(41)31(24-28)43-8/h10,12-14,17,24,27,29,32-34,41H,9,11,15-16,18-23,25H2,1-8H3/b17-13+/t27-,29-,32+,33+,34+,37-,38+,39-,40+/m1/s1
InchiKey	FODTZLFLDFKIQH-FSVGXZBPSA-N
分子式 Formula	C40H58O4
分子量 Molecular Weight	602.89
闪点 FP	193.8±20.8 °C
熔点 Melting point	156 - 160°C
沸点 Boiling point	663.2±40.0 °C at 760 mmHg
Polarizability极化度	70.8±0.5 10-24cm3
密度 Density	1.1±0.1 g/cm3
蒸汽压 Vapor Pressure	0.0±2.1 mmHg at 25°C
溶解度Solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
性状	白色或白色结晶性粉末，无味
储藏条件 Storage conditions	在密闭容器中阴凉处保持密闭。

谷维素(11042-64-1,γ-Oryzanol)毒理性质：

生物	测试类型	路线	剂量	影响	参考
rat	LD50	oral	>25 gm/kg (25000 mg/kg)		Drugs in Japan, -(297), 1995
rat	LD50	skin	100 mg/kg (100 mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics., 7(1295), 1979
rat	LDLo	intraperitoneal	1250 mg/kg (1250 mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY); GASTROINTESTINAL: HYPERMOTILITY, DIARRHEA; SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kiso to Rinsho. Clinical Report., 7(2781), 1973
rat	LD	subcutaneous	>1 gm/kg (1000 mg/kg)		Kiso to Rinsho. Clinical Report., 7(2781), 1973
rat	LD50	intravenous	382 mg/kg (382 mg/kg)		Drugs in Japan, -(297), 1995
rat	LD	intramuscular	>500 mg/kg (500 mg/kg)		Kiso to Rinsho. Clinical Report., 7(2781), 1973
mouse	LD50	oral	>25 gm/kg (25000 mg/kg)		Drugs in Japan, -(297), 1995
mouse	LD	intraperitoneal	>10 gm/kg (10000 mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY); GASTROINTESTINAL: HYPERMOTILITY, DIARRHEA; SKIN AND APPENDAGES (SKIN): HAIR: OTHER	Kiso to Rinsho. Clinical Report., 7(2781), 1973
mouse	LD	subcutaneous	>2500 mg/kg (2500 mg/kg)		Kiso to Rinsho. Clinical Report., 7(2781), 1973
mouse	LD50	intravenous	811 mg/kg (811 mg/kg)		Drugs in Japan, -(297), 1995
mouse	LD	intramuscular	>500 mg/kg (500 mg/kg)		Kiso to Rinsho. Clinical Report., 7(2781), 1973
dog	LD	oral	>5 gm/kg (5000 mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics., 6(2401), 1978
rabbit	LD	oral	>5 gm/kg (5000 mg/kg)	GASTROINTESTINAL: HYPERMOTILITY, DIARRHEA	Yakuri to Chiryo. Pharmacology and Therapeutics., 6(2401), 1978
rabbit	LD	subcutaneous	>2500 mg/kg (2500 mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics., 6(2401), 1978
guinea pig	LD50	skin	100 mg/kg (100 mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics., 7(1295), 1979

谷维素(11042-64-1,γ-Oryzanol)实验注意事项：
1.实验前需戴好防护眼镜，穿戴防护服和口罩，佩戴手套，避免与皮肤接触。
2.实验过程中如遇到有毒或者刺激性物质及有害物质产生，必要时实验操作需要手套箱内完成以免对实验人员造成伤害
3.实验后产生的废弃物需分类存储，并交于专业生物废气物处理公司处理，以免造成环境污染Experimental considerations:
1. Wear protective glasses, protective clothing and masks, gloves, and avoid contact with the skin during the experiment.
2. The waste generated after the experiment needs to be stored separately, and handed over to a professional biological waste gas treatment company to avoid environmental pollution.

Tags:谷维素试剂,谷维素杂质,谷维素中间体,谷维素合成,谷维素密度,谷维素溶解度,谷维素旋光度,谷维素闪点,谷维素购买,谷维素MSDS,

产品说明	谷维素(11042-64-1)是降血脂剂,谷维素是抗溃疡剂,谷维素有效抑制小鼠纹状体中的DNA甲基转移酶,谷维素溶解度,谷维素MSDS等其他参数详见主页.
Introduction	谷维素(11042-64-1,γ-Oryzanol)Effectively inhibit DNA methyltransferases (DNMTs) in mouse striatum. Inhibit DNMT1 and DNMT3a with IC50 of 3.2μM and 22.3μM, respectively.
Application1	谷维素可以降低血液中某些LIPIDS含量的物质。谷维素可用于治疗高脂血症。谷维素可以降低血液中某些LIPIDS含量的物质。
Application2	谷维素是抗溃疡剂，谷维素具有不同作用机制的各种药剂可用于治疗或改善PEPTIC ULCER或胃肠道刺激。其中包括用于治疗幽门螺杆菌感染的抗生素；组胺H2拮抗剂可减少胃酸分泌；和ANTACIDS用于缓解症状。
Application3	谷维素(11042-64-1,γ-Oryzanol)有效抑制小鼠纹状体中的DNA甲基转移酶(DNMTs).抑制DNMT1和DNMT3a,IC50分别为3.2μM和22.3μM.

谷维素(11042-64-1,γ-Oryzanol)药理学：

※谷维素(11042-64-1,γ-Oryzanol)有效抑制小鼠纹状体中的DNA甲基转移酶(DNMTs).抑制DNMT1和DNMT3a,IC₅₀ 分别为3.2μM和22.3μM。具有催化活性的生物分子。它们可能是自然发生的，也可能是综合产生的。酶通常是蛋白质，但是也已经鉴定出催化RNA和催化DNA分子。谷维素可作为受体氧化还原酶。只要可能，建议的名称是脱氢酶。作为替代，可以使用还原酶。氧化酶仅在O2为受体的情况下使用。

※谷维素是降血脂剂，降低血液中某些LIPIDS含量的物质。它们用于治疗高脂血症。

※谷维素是抗溃疡剂，谷维素具有不同作用机制的各种药剂可用于治疗或改善PEPTIC ULCER或胃肠道刺激。其中包括用于治疗幽门螺杆菌感染的抗生素；组胺H2拮抗剂可减少胃酸分泌；和ANTACIDS用于缓解症状。

警示图
危险性	warning
危险性警示	Not available急性毒性
安全声明	H303+H313+H333
安全防护	P264+P280+P305+P351+P338+P337+P313
备注	实验过程中防止吸入、食入，做好安全防护

谷维素(11042-64-1,γ-Oryzanol)危害标识：

象形图
信号	Danger
GHS危险说明	Aggregated GHS information provided by 3 companies from 1 notifications to the ECHA C&L Inventory.
	H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]
	Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
防范说明代码	P262, P264, P270, P280, P302+P350, P310, P322, P361, P363, P405, and P501
防范说明代码	(The corresponding statement to each P-code can be found at the GHS Classification page.)

Kozuka C, et al. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia. 2017 Aug;60(8):150

Significance of the Natural Occurrence of L- Versus D-Pipecolic Acid: A Review Chirality 2013 10.1002/chir.22237

Continuous Flow Organic Synthesis under High-Temperature/Pressure Conditions Chem. Asian J. 2010 10.1002/asia.201000010

Cycloartenyl Ferulate Inhibits Paraquat-Induced Apoptosis in HK-2 Cells With the Involvement of ABCC1 Journal of cellular biochemistry，26358524 2016-04-01

γ-Oryzanol protects against acute cadmium-induced oxidative damage in mice testes Food and chemical toxicology : an international journal published for the British Industrial Biological Research Assoc

谷维素(11042-64-1,γ-Oryzanol)参考文献：

1.Effect of natural compounds on Fusarium graminearum complex.
Heidtmann-Bemvenuti R1, Tralamazza SM2, Ferreira CF1, Corrêa B2, Badiale-Furlong E1. J Sci Food Agric. 2015 Dec 24. doi: 10.1002/jsfa.7591. [Epub ahead of print]

BACKGROUND: A search is underway for new solutions to counter farm loss caused by fungal contamination of grains, since the active agents of fungicides can remain in the environment contribute to the development of resistant and toxigenic species. In this study, the antifungal activity of natural compounds (γ-oryzanol, phenolic extract of neem seeds and of rice bran) was assessed on 3 toxigenic strains of Fusarium graminearum isolated from wheat, rice and barley. Their efficacy was compared to that of synthetic fungicides. The halo diameters were measured and the susceptible pathways were determined by the levels of structural compounds and activities of enzymes involved in the primary metabolism of the microorganisms. Moreover, mycotoxin production and gene expression were examined.

2.Microwave (MW) promoted high yield expedient synthesis of steryl ferulates - A class of novel biologically active compounds: A comparative study of their antioxidant activity with that of naturally occurring γ-oryzanol.
Begum A1, Borah P1, Chowdhury P2. Steroids. 2016 Mar;107:37-44. doi: 10.1016/j.steroids.2015.12.017. Epub 2015 Dec 29.

Synthetic steryl ferulates [3-O-(trans-4-feruloyl)-sterols] are currently gaining considerable importance in recent years to be used as nutraceuticals and food additives as well as in pharmaceutical applications substituting γ-oryzanol - a class of naturally occurring steryl ferulates having potent antioxidant and other organoleptic properties. Considering the importance of this class of compounds coupled with green technology associated with microwave energy (MW) in organic synthesis, we report here an expedited and high yield synthesis of steryl ferulates from abundant steroids, viz., cholesterol, cholestanol, stigmasterol, stigmastanol, β-sitosterol, β-campesterol, β-campestanol and ergosterol applying MW energy in the crucial step of esterification process of sterols with trans-4-O-acetylferulic acid to furnish their esterified products, viz., 3-O-(trans-4-O-acetylferuloyl)-sterols for their eventual deprotection to their respective steryl ferulates.

3.Rice Bran Nutraceutics: A Comprehensive Review.
Sohail M1, Rakha A1, Butt MS1, Iqbal MJ1, Rashid S1. Crit Rev Food Sci Nutr. 2016 Mar 25:0. [Epub ahead of print]

Agro-industry yields ample quantity of several byproducts with considerable importance. These byproducts are mostly under-utilized, often used as animal feed or rejected as waste, hence their true potential is not harnessed. The use of such superfluous resources is not only of economic significance but also a form of commercial recycling. Rice bran is an important byproduct of rice milling industry with a global potential of 29.3 million tons annually. It is gaining great attention of the researchers due to its nutrient rich composition, easy availability, low cost, high antioxidant potential and promising effects against several metabolic ailments. Bioactive components of rice bran, mainly γ-oryzanol, have been reported to possess antioxidant, anti-inflammatory, hypocholesterolemic, anti-diabetic and anti-cancer activities. Rice bran oil contain appreciable quantities of bioactive components and has attained the status of "Heart oil" due to its cardiac friendly chemical profile.

4.[Using liquid chromatography-mass spectrometry based metabolomics to discriminate between cold pressed rice bran oils produced from two different cultivars of Oryza sativa L. ssp. indica in Thailand].
Charoonratana T, Songsak T, Sakunpak A, Pathompak P, Charoenchai L. Se Pu. 2015 Sep;33(9):966-73.

A newly developed liquid chromatography-mass spectrometry (LC-MS) method for the analysis of cold pressed rice bran oil (RBO) was established and used to discriminate between RBOs produced from two different cultivars of major Thai fragrant rice species. The cold pressed RBO was prepared using the screw compression method. The LC-MS data were preprocessed with MZmine 2.10 program before evaluating with principal component analysis using SIMCA 13 software. The LC-MS method was able to detect and quantify several kinds of valuable constituents such as fatty acids, vitamin E, and γ-oryzanol. The chromatographic condition was feasible; short time for analysis and simple method were achieved. From score plot and loading plot of principle component analysis (PCA) , two rice cultivar samples were clearly separated, and it was revealed that Khao-Hom-Pathum was more suitable than Khao-Hom-Mali for cold pressed RBO production since it contained high total γ-oryzanol and less saturated free fatty acids.

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