20300-59-8|7-甲氧基香豆素-3-羧酸|7-Methoxycoumarin-3-carboxylic Acid|MFCD00452770-范德生物科技公司

7-甲氧基香豆素-3-羧酸
NMR and HPLC COA下载 MSDS下载
Names：
7-Methoxycoumarin-3-carboxylic Acid
CAS号：
20300-59-8
MDL Number： MFCD00452770
MF(分子式)： C11H8O5 MW(分子量)： 220.18
EINECS: Reaxys Number:384199
Pubchem ID:135727041 Brand:BIOFOUNT

7-甲氧基香豆素-3-羧酸 7-Methoxycoumarin-3-carboxylic acid (20300-59-8)在某些多色荧光应用（如核酸和蛋白质微阵列、原位杂交和免疫荧光）中与更长波长的探针一起使用时，可提供可区分的对比度。荧光：λex 330 nm; λem 402 nm in 0.1 M Tris pH 9.0。还用于开发用于分析蛋白酶活性的 FRET 探针。

货品编码	规格	纯度	价格 (¥)	现价(¥)	库存描述	数量	总计 (¥)
HCC327856-1g	1g	97%	¥ 2150.00	¥ 2150.00	Instock1days	- +	¥ 0.00
HCC327856-500mg	500mg	97%	¥ 1290.00	¥ 1290.00	Instock1days	- +	¥ 0.00
HCC327856-100mg	100mg	97%	¥ 370.00	¥ 370.00	Instock1days	- +	¥ 0.00

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中文别名	7-甲氧基香豆素-3-羧酸;20300-59-8;Amine-reactive fluorescent probe;7-Methoxy-2-oxo-2H-1-benzopyran-3-carboxylic acid ;MC
英文别名	7-Methoxycoumarin-3-carboxylic Acid
CAS号	20300-59-8
SMILES	COC1=CC2=C(C=C1)C=C(C(=O)O2)C(=O)O
Inchi	1S/C11H8O5/c1-15-7-3-2-6-4-8(10(12)13)11(14)16-9(6)5-7/h2-5H,1H3,(H,12,13)
InchiKey	EEGNDSSWAOLFN-UHFFFAOYSA-N
分子式 Formula	C11H8O5
分子量 Molecular Weight	220.18
闪点 FP	No data available
熔点 Melting point	194.0 to 198.0 °C
沸点 Boiling point	424.4oC at 760 mmHg
Polarizability极化度
密度 Density	1.454g/cm3
蒸汽压 Vapor Pressure
溶解度Solubility	Soluble in DMSO
性状	solid
储藏条件 Storage conditions	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

产品说明	7-甲氧基香豆素-3-羧酸 7-Methoxycoumarin-3-carboxylic acid (20300-59-8)在某些多色荧光应用（如核酸和蛋白质微阵列、原位杂交和免疫荧光）中与更长波长的探针一起使用时，可提供可区分的对比度。
Introduction	7-Methoxycoumarin-3-carboxylic Acid(CAS:20300-59-8):only use for non-medical purposes in industrial or scientific research, and not for clinical diagnosis and treatment of humans or animals. This product is not medicinal or edible.
Application1
Application2
Application3

警示图
危险性
危险性警示
安全声明	H315 : 造成皮肤刺激。 H319 : 造成严重眼刺激。
安全防护	P264 : 作业后彻底清洗皮肤。 P280 : 戴防护手套/戴防护眼罩/戴防护面具。 P302 + P352 : 如皮肤沾染：用水充分清洗。 P337 + P313 : 如仍觉眼刺激：求医/就诊。 P305 + P351 + P338 : 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P362+P364 : 脱掉沾污的衣服，清洗后方可重新使用。 P332 + P313 : 如发生皮肤刺激：求医/就诊。
备注

1.Evaluation of a 7-Methoxycoumarin-3-carboxylic Acid Ester Derivative as a Fluorescent, Cell-Cleavable, Phosphonate Protecting Group.

2. An alternative quenched fluorescence substrate for Pz-peptidase Authors: Tisljar U, et al. Journal: Anal Biochem (1990): 112-5

3. Quantitation of platelet-activating factor by high-performance liquid chromatography with fluorescent detection Authors: Mita H, Yasueda H, Hayakawa T, Shida T. Journal: Anal Biochem (1989): 131

1.Evaluation of a 7-Methoxycoumarin-3-carboxylic Acid Ester Derivative as a Fluorescent, Cell-Cleavable, Phosphonate Protecting Group.
Wiemer AJ1, Shippy RR2, Kilcollins AM3, Li J1, Hsiao CH1, Barney RJ4, Geng ML5, Wiemer DF6. Chembiochem. 2016 Jan 1;17(1):52-5. doi: 10.1002/cbic.201500484. Epub 2015 Nov 19.
Cell-cleavable protecting groups often enhance cellular delivery of species that are charged at physiological pH. Although several phosphonate protecting groups have achieved clinical success, it remains difficult to use these prodrugs in live cells to clarify biological mechanisms. Here, we present a strategy that uses a 7-methoxycoumarin-3-carboxylic acid ester as a fluorescent protecting group. This strategy was applied to synthesis of an (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) analogue to assess cellular uptake and human Vγ9Vδ2 T?cell activation. The fluorescent ester displayed low cellular toxicity (IC50 >100 μm) and strong T cell activation (EC50 =0.018 μm) relative to the unprotected anion (EC50 =23 μm). The coumarin-derived analogue allowed no-wash analysis of biological deprotection, which revealed rapid internalization of the prodrug. These results demonstrate that fluorescent groups can be applied both as functional drug delivery tools and useful biological probes of drug uptake.

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